Review
Cardiac & Cardiovascular Systems
Kate Ralston, Ezequiel Zaidel, Harry Acquatella, Marcia Melo Barbosa, Jagat Narula, Yu Nakagama, Gustavo Restrepo Molina, Karen Sliwa, Jose Luis Zamorano, Fausto J. Pinto, Daniel Jose Pineiro, Mariana Corneli
Summary: Chagas disease is a significant health burden in Latin America and globally, and its cardiac involvement, known as Chagas cardiomyopathy, is the most severe manifestation. Echocardiography plays a crucial role in the diagnosis, monitoring, and risk assessment of Chagas cardiomyopathy.
Article
Cardiac & Cardiovascular Systems
Mirae Lee, Alon Shechter, Donghee Han, Long-Co Nguyen, Min Sun Kim, Daniel S. Berman, Florian Rader, Robert J. Siegel
Summary: This study evaluated the morphologic progression of the left ventricle (LV) in apical hypertrophic cardiomyopathy (AHC) patients using serial echocardiograms. The results showed that about half of the patients had changes in LV morphology, with some patients experiencing further hypertrophic involvement and the development of apical pouches or aneurysms. The study also found that patients with more severe LV hypertrophy and apical involvement had higher rates of adverse clinical events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hyun-Jung Lee, Hyung-Kwan Kim, Tae-Min Rhee, You-J Ung Choi, In-Chang Hwang, Yeonyee E. Yoon, Jun-Bean Park, Seung-Pyo Lee, Yong-Jin Kim, Goo-Yeong Cho
Summary: LARS can be used to categorize LV diastolic function and predict HF events in patients with hypertrophic cardiomyopathy.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Maciej Stapor, Adam Pilat, Andrzej Gackowski, Agnieszka Misiuda, Izabela Gorkiewicz-Kot, Michal Kaleta, Pawel Kleczynski, Krzysztof Zmudka, Jacek Legutko, Boguslaw Kapelak, Karol Wierzbicki
Summary: This study evaluates the feasibility of physiological pump speed optimization based on aortic valve opening (AVO) imaging during a cardiopulmonary exercise test (CPET) in LVAD patients. The results show that dynamic echo-guided pump speed adjustment based on AVO improves exercise tolerance and augments peak oxygen consumption and maximum workload.
Review
Cardiac & Cardiovascular Systems
Francesco Bandera, Anita Mollo, Matteo Frigelli, Giulia Guglielmi, Nicoletta Ventrella, Maria Concetta Pastore, Matteo Cameli, Marco Guazzi
Summary: The left atrium plays a crucial role in the pathophysiology of cardiac diseases, particularly heart failure. Its adaptive ability and remodeling are important in preventing or delaying the onset of heart failure symptoms. Early signs of left atrial dysfunction can predict the clinical course of heart failure diseases, and imaging techniques are essential for evaluating left atrial mechanics and improving clinical practice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Silvia Oghina, Wulfran Bougouin, Mounira Kharoubi, Louis Bonnefous, Arnault Galat, Soulef Guendouz, Melanie Bezard, Fabien Le Bras, Jean-Francois Deux, Emmanuel Itti, Anissa Moktefi, Pascale Fanen, Emmanuel Teiger, Dania Mohty, Thibaud Damy, Diane Bodez
Summary: All LVDF patterns can be observed in CA, and one quarter of CA patients have a better prognosis with grade I LVDF.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Luke C. Pickup, Jonathan P. Law, Ashwin Radhakrishnan, Anna M. Price, Charalampos Loutradis, Toby O. Smith, Nicola C. Edwards, Richard P. Steeds, Jonathan N. Townend, Charles J. Ferro
Summary: The study aimed to investigate if uraemic cardiomyopathy can be reversed by renal transplantation. Findings from meta-analyses of various studies suggested that there was no significant difference in left ventricular mass index, ejection fraction, or end-diastolic volume after transplantation. However, methodological weaknesses in the evidence should be taken into consideration when interpreting these results.
Article
Cardiac & Cardiovascular Systems
Dominic Emerson, Joanna Chikwe, Pedro Catarino, Mohamed Hassanein, Luqin Deng, Ryan S. Cantor, Amy Roach, Robert Cole, Fardad Esmailian, Jon Kobashigawa, Jaime Moriguchi, James K. Kirklin
Summary: In contemporary practice, elderly patients receiving LVADs showed improved survival, increased functional capacity, enhanced quality of life, and fewer complications compared with younger patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mark Sherrid, Samuel Bernard, Nidhi Tripathi, Yash Patel, Vivek Modi, Leon Axel, Soheila Talebi, Brian B. Ghoshhajra, Danita Y. Sanborn, Muhamed Saric, Elizabeth Adlestein, Isabel Castro Alvarez, Yuhe Xia, Daniel G. Swistel, Daniele Massera, Michael A. Fifer, Bette Kim
Summary: This study investigated the frequency of mid-LV obstruction in apical aneurysms of hypertrophic cardiomyopathy (HCM). The results showed that 95% of patients with aneurysms had mid-LV obstruction. Further research is needed to explore the relationship between mid-LV obstruction and aneurysms.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Meng-Ting Shen, Yuan Li, Ying-Kun Guo, Li Jiang, Yue Gao, Rui Shi, Zhi-Gang Yang
Summary: Type 2 diabetes mellitus (T2DM) has an additive deleterious effect on left ventricular (LV) function in patients with non-ischemic dilated cardiomyopathy (NIDCM), and elevated blood glucose level is associated with reduced myocardial strain.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elisa Dal Canto, Marielle Scheffer, Kirsten Kortekaas, Annet Driessen-Waaijer, Walter J. Paulus, Loek van Heerebeek
Summary: In patients with HFpEF, NP levels can be used to identify different stages of LV remodeling and myocardial tissue composition. This study found that HFpEF patients with high NP levels had worse LV stiffness and left atrial function, indicating advanced stage of HFpEF.
Article
Cardiac & Cardiovascular Systems
Jay Ramchand, Pooja Podugu, Nancy Obuchowski, Serge C. Harb, Michael Chetrit, Alex Milinovich, Brian Griffin, Louise M. Burrell, W. H. Wilson Tang, Deborah H. Kwon, Scott D. Flamm
Summary: This study aimed to evaluate whether the presence of a thin compacted myocardial layer leads to poorer outcomes in patients with left ventricular non-compaction. The results showed that the risk of adverse clinical events is increased in the presence of significant compacted myocardial thinning, an elevated B-type natriuretic peptide, or increased left ventricular dimensions. These markers could enhance risk assessment and help reduce overdiagnosis of left ventricular non-compaction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Medicine, General & Internal
Emanuele Monda, Marta Rubino, Giuseppe Palmiero, Federica Verrillo, Michele Lioncino, Gaetano Diana, Annapaola Cirillo, Adelaide Fusco, Francesca Dongiglio, Martina Caiazza, Ippolita Altobelli, Alfredo Mauriello, Natale Guarnaccia, Alessandra Scatteia, Arturo Cesaro, Giuseppe Pacileo, Berardo Sarubbi, Giulia Frisso, Barbara Bauce, Antonello D'Andrea, Santo Dellegrottaglie, Maria Giovanna Russo, Paolo Calabro, Giuseppe Limongelli
Summary: Arrhythmogenic cardiomyopathy (ACM) is a broad term for myocardial diseases characterized by progressive fibrotic or fibrofatty replacement, which leads to ventricular tachyarrhythmias and ventricular dysfunction. Arrhythmogenic left ventricular cardiomyopathy (ALVC) is a specific subtype that exclusively affects the left ventricle. Diagnosis of ALVC requires a combination of family history, clinical, electrocardiographic, and imaging features, with genetic testing for confirmation. Multimodality imaging techniques, such as echocardiography, cardiac magnetic resonance, and cardiac nuclear imaging, are essential for diagnosis, differential diagnosis, risk stratification, and management of ALVC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Anne-Iris Lemaitre, Francois Picard, Vincent Maurin, Maxime Faure, Pierre Dos Santos, Nicolas Girerd
Summary: The study focused on the midterm prognosis of left ventricular thrombus (LVT) in heart failure patients with dilated cardiomyopathy (DCM) and ischaemic cardiomyopathy (ICM). The results showed that natriuretic peptide levels, especially BNP, play a significant role in the development of LVT in DCM patients. Symptomatic embolic events and/or all-cause mortality were observed in 20% of the population, with most cases occurring within 30 days of LVT diagnosis despite anticoagulant treatment.
Review
Cardiac & Cardiovascular Systems
Davide Margonato, Francesco Ancona, Giacomo Ingallina, Francesco Melillo, Stefano Stella, Federico Biondi, Antonio Boccellino, Cosmo Godino, Alberto Margonato, Eustachio Agricola
Summary: Tricuspid regurgitation (TR), historically not considered a primary healthcare problem, has recently gained attention from the scientific community. TR can complicate heart failure, most commonly as a functional disease, and its independent prognostic role is still debated. The relationship between TR and LVSD, as well as the potential therapeutic target of TR, remains unclear.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Theodor Fischlein, Bart Meuris, Thierry Folliguet, Kavous Hakim-Meibodi, Martin Misfeld, Thierry Carrel, Marian Zembala, Elisa Cerutti, Federico M. Asch, Axel Haverich
Summary: This study reports the midterm clinical outcomes of a self-expandable sutureless aortic valve. The results show that this technology is associated with low mortality and morbidity rates, and good hemodynamic performance.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Igor Ferreira de Sales, Lucas Lodi-Junqueira, Guilherme Rafael Sant'Anna Athayde, Marta Eugenia Alcici, Tatiana Costa Diamantino, Lucas Campos Barbosa e Silva, Frederico Vargas Botinha Macedo, Clara Leal Fraga, Breno Camargos Mucelli Spalaor, Pedro Victor Silva Valente, Juliana Rodrigues Soares, Timothy C. Tan, William Antonio de Magalhaes Esteves, Maria Carmo Pereira Nunes
Summary: This study aimed to assess the parameters associated with abnormal pulmonary artery pressure (PAP) response immediately after a successful percutaneous mitral valvuloplasty (PMV) and its impact on long-term outcome. The results showed that pulmonary pressures may not reduce immediately after the procedure, however, this lack of immediate reduction is not associated with long-term adverse outcomes.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Airandes de Sousa Pinto, Maria Carmo Pereira Nunes, Carlos Alberto Rodrigues, Braulio Muzzi Ribeiro de Oliveira, Joao da Rocha Medrado, Timothy C. Tan, Manoel Otavio da Costa Rocha
Summary: This study aimed to demonstrate the hemodynamic adaptations in Chagas cardiomyopathy (CC) using volume and flow measurements obtained by three-dimensional echocardiography (3D ECHO). The results showed that an increase in left ventricular (LV) end-diastolic volume may be the main adaptation mechanism that maintains flow and stroke volume in severe LV systolic dysfunction.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2022)
Article
Engineering, Biomedical
Luiz Eduardo Virgilio Silva, Henrique Turin Moreira, Marina Madureira de Oliveira, Lorena Sayore Suzumura Cintra, Helio Cesar Salgado, Rubens Fazan, Renato Tinos, Anis Rassi, Andre Schmidt, J. Antonio Marin-Neto
Summary: This study investigated the role of heart rate variability (HRV) in risk stratification for Chronic Chagas Cardiomyopathy (CCC) and compared HRV alterations between isolated CCC and mixed CCC with digestive involvement. The results showed that the mixed form of CCC exhibited decreased slow HRV components, while increased heart rate fragmentation was associated with worse prognosis in CCC. The combination of HRV indices improved the accuracy of risk stratification.
BIOMEDICAL ENGINEERING ONLINE
(2022)
Article
Immunology
Pauline Brochet, Barbara Ianni, Joao P. S. Nunes, Amanda F. Frade, Priscila C. Teixeira, Charles Mady, Ludmila R. P. Ferreira, Andreia Kuramoto, Cristina W. Pissetti, Bruno Saba, Darlan D. S. Candido, Fabricio Dias, Marcelo Sampaio, Jose A. Marin-Neto, Abilio Fragata, Ricardo C. F. Zaniratto, Sergio Siqueira, Giselle D. L. Peixoto, Vagner O. C. Rigaud, Paula Buck, Rafael R. Almeida, Hui Tzu Lin-Wang, Andre Schmidt, Martino Martinelli, Mario H. Hirata, Eduardo Donadi, Virmondes Rodrigues Junior, Alexandre C. Pereira, Jorge Kalil, Lionel Spinelli, Edecio Cunha-Neto, Christophe Chevillard
Summary: This study proposes two sets of DNA methylation biomarkers that can predict the occurrence and stage of Chagas disease cardiomyopathy. Using machine learning algorithms, predictions in a test cohort achieved an accuracy of over 95%. These biomarkers are also associated with immune response, nervous system, ion transport, and ATP synthesis pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Pauline Brochet, Barbara Maria Ianni, Laurie Laugier, Amanda Farage Frade, Joao Paulo Silva Nunes, Priscila Camillo Teixeira, Charles Mady, Ludmila Rodrigues Pinto Ferreira, Quentin Ferre, Ronaldo Honorato Barros Santos, Andreia Kuramoto, Sandrine Cabantous, Samuel Steffen, Antonio Noedir Stolf, Pablo Pomerantzeff, Alfredo Inacio Fiorelli, Edimar Alcides Bocchi, Cristina Wide Pissetti, Bruno Saba, Darlan da Silva Candido, Fabricio C. Dias, Marcelo Ferraz Sampaio, Fabio Antonio Gaiotto, Jose Antonio Marin-Neto, Abilio Fragata, Ricardo Costa Fernandes Zaniratto, Sergio Siqueira, Giselle De Lima Peixoto, Vagner Oliveira-Carvalho Rigaud, Fernando Bacal, Paula Buck, Rafael Ribeiro Almeida, Hui Tzu Lin-Wang, Andre Schmidt, Martino Martinelli, Mario Hiroyuki Hirata, Eduardo Antonio Donadi, Alexandre Costa Pereira, Virmondes Rodrigues Junior, Denis Puthier, Jorge Kalil, Lionel Spinelli, Edecio Cunha-Neto, Christophe Chevillard
Summary: In this study, the genetic and epigenetic deregulations associated with moderate and severe stages of Chagas disease were investigated using bulk RNA-seq and DNA methylation analysis. The results revealed differentially expressed transcripts and regulatory differentially methylated regions in the heart tissue of CCC patients. Transcription factors binding sites affected by DNA methylation were also identified. The study identified biological processes affected by severe CCC and highlighted the importance of ion transport and the nervous system in the development of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Shamir R. Mehta, Jia Wang, David A. Wood, John A. Spertus, David J. Cohen, Roxana Mehran, Robert F. Storey, Philippe Gabriel Steg, Natalia Pinilla-Echeverri, Tej Sheth, Kevin R. Bainey, Sripal Bangalore, Warren J. Cantor, David P. Faxon, Laurent J. Feldman, Sanjit S. Jolly, Vijay Kunadian, Shahar Lavi, Jose Lopez-Sendon, Mina Madan, Raul Moreno, Sunil Rao, Josep Rodes-Cabau, Goran Stankovic, Shrikant Bangdiwala, John A. Cairns
Summary: Complete revascularization in patients with STEMi and multivessel CAD leads to a slightly higher proportion of angina-free patients compared to culprit lesion-only strategy.
Article
Cardiac & Cardiovascular Systems
Sergio Alejandro Gomez-Ochoa, Lyda Z. Rojas, Luis E. Echeverria, Taulant Muka, Oscar H. Franco
Summary: The global burden of Chagas disease has changed in recent decades, with a sustained decline in the number of cases. While the majority of cases remain concentrated in Latin America, the increase observed in North America and Europe highlights the importance of screening and raising awareness among at-risk populations.
Article
Cardiac & Cardiovascular Systems
Daniel Peck, Andrea Beaton, Maria Carmo Nunes, Nicholas Ollberding, Allison Hays, Pranoti Hiremath, Federico Asch, Nitin Malik, Christopher Fung, Craig Sable, Bruno Nascimento
Summary: This study aimed to assess the prognostic value of right ventricular (RV) and left ventricular (LV) dysfunction in COVID-19 patients admitted to the emergency departments (ED) in the US. The study also evaluated the feasibility of using cloud imaging for sharing and interpreting echocardiograms. The results showed that age and oxygen saturation were independent predictors of death and ICU admission, while echocardiographic variables did not improve the prediction of unfavorable outcomes.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Maria Carmo Pereira Nunes, Jose Augusto Almeida Barbosa, Ana Mocumbi
Article
Cardiac & Cardiovascular Systems
Luiz Oaulo Bastos Vasconcelos, Marcelle Cristina da Silva Bastos Vasconcelos, Francisco Biagio Murta E. di Flora, Flavio Augusto Pael de Oliveira, Pedro Drummond Lima, Lucas Campos Barbosa E. Silva, Breno Camargos Mucelli Spolaor, Jose Luiz Padilha da Silva, William Antonio de Magalhaes Esteves, Maria Carmo P. Nunes, Antonio Lucio Teixeira
Summary: This study assessed the prevalence of neuropsychiatric manifestations in patients with rheumatic heart disease (RHD), finding that these manifestations are common in RHD patients. Age, major depression, and severity of obsessive-compulsive symptoms were independently associated with basal ganglia motor dysfunction.
Article
Public, Environmental & Occupational Health
Ariela Mota Ferreira, Ester Cerdeira Sabino, Lea Campos de Oliveira-da Silva, Claudia Di Lorenzo Oliveira, Clareci Silva Cardoso, Antonio Luiz Pinho Ribeiro, Renata Fiuza Damasceno, Samara Fernandes Leite, Thallyta Maria Vieira, Maria do Carmo Pereira Nunes, Desiree Sant' Ana Haikal
Summary: This study evaluated the prevalence of poor self-rated health among Chagas disease patients in an endemic region in Brazil, and found the influence of the organization of the Brazilian public health service and individual characteristics on their self-perceived health.
CIENCIA & SAUDE COLETIVA
(2022)
Article
Cardiac & Cardiovascular Systems
Omar Ribeiro Santos Junior, Ester Cerdeira Sabino, Vinicius Tostes Carvalho, Bruno Oliveira de Figueiredo Brito, Lea Campos de Oliveira, Ariela Mota Ferreira, Marcelo Alves Maia, Nayana Flamini Arantes Gomes, Antonio Luiz P. Ribeiro, Maria Carmo P. Nunes
Summary: This study examined the left ventricular global longitudinal strain (GLS) in a large Chagas disease population and found that a significant proportion of patients had impaired GLS despite normal electrocardiogram and preserved ejection fraction. The main factors associated with reduced GLS included ST-T abnormalities, QRS duration, LVEF, and E/e' ratio.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2022)
Review
Parasitology
Thais Aparecida Reis Lage, Julia Teixeira Tupinambas, Lucas Bretas de Padua, Matheus de Oliveira Ferreira, Amanda Cambraia Ferreira, Antonio Lucio Teixeira, Maria Carmo Pereira Nunes
Summary: Despite progress in control efforts, Chagas disease remains a significant public health problem in Latin America and globally. The disease affects millions of people and can lead to serious cardiac complications, including cardiomyopathy. Chagas disease is also a risk factor for stroke, with cardioembolism being the commonly accepted mechanism, although other etiologies have been observed. The exact mechanisms contributing to stroke in Chagas disease are still unclear.
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2022)
Article
Cardiac & Cardiovascular Systems
Gemma Reddin, Brian J. Forrestal, Hector M. Garcia-garcia, Diego Medvedofsky, Manavotam Singh, Federico M. Asch, Henrique B. Ribeiro, Carlos M. Campos
Summary: This study investigated the feasibility and advantages of using strain analysis to classify Takotsubo cardiomyopathy, finding that involvement of the entire left ventricle is common and strain analysis has prognostic significance.
MINERVA CARDIOLOGY AND ANGIOLOGY
(2022)
