Article
Plant Sciences
Muna Rajab Elferjane, Aleksandra A. Jovanovic, Violeta Milutinovic, Natalija Cutovic, Milica Jovanovic Krivokuca, Aleksandar Marinkovic
Summary: The optimization of extraction from Aloe vera leaf waste was conducted by changing solid-to-solvent ratio, solvent type, extraction time, and technique. The study found that the highest polyphenol content was achieved with a 1:30 ratio, 70% ethanol, and 30 minutes of heat-assisted extraction. Different extraction techniques resulted in variations in the flavonoid, protein, and tannin contents of the extracts. LC-MS analysis identified multiple compounds and the extraction conditions influenced the antioxidant ability of the extracts.
Review
Nutrition & Dietetics
Maria Leonor Silva, Keyla Rita, Maria Alexandra Bernardo, Maria Fernanda de Mesquita, Ana Maria Pintao, Margarida Moncada
Summary: Adansonia digitata L. fruit, known as baobab, has been traditionally used for its medicinal properties. It has various pharmacological uses, such as hydration, antipyretic, antiparasitic, antitussive, sudorific, and treatment of diarrhea and dysentery. Additionally, baobab has antioxidant, anti-inflammatory, analgesic, and antimicrobial activities due to its bioactive compounds. It is also a rich source of vitamin C, zinc, potassium, magnesium, iron, calcium, and protein. However, there is a lack of information on the mechanisms of action and clinical trials regarding the effects of baobab on glycemia regulation.
Review
Biochemistry & Molecular Biology
Annachiara Tesoriere, Alberto Dinarello, Francesco Argenton
Summary: STAT3 is a crucial transcription factor regulating cell growth and proliferation by controlling gene transcription; it plays significant roles in cancer progression, with different post-translational modifications having opposite effects in different cellular models; the extensive results from various studies show that post-translational modifications drastically alter STAT3 activities, necessitating further analysis to fully elucidate its multifaceted functions.
Review
Pharmacology & Pharmacy
Fahad Hussain Mohammed, Franz Cemic, Joergen Hemberger, Shibashish Giri
Summary: Epigenetic regions such as VEGF, EGFR, TGFb, DNMTs, HDAC1/2, and miRNA are innovative druggable targets for building a novel platform of drugs for preventive and regenerative skin health care. Clinical and preclinical trials are being conducted for skin regeneration using epigenetic-based small molecules. Epigenetic writers, eraser targets, and epigenetic readers will play a crucial role in skin regenerative therapy in the near future.
DRUG DISCOVERY TODAY
(2023)
Article
Food Science & Technology
Yahya S. Hamed, Hafiz Muhammad Saleem Akhtar, Ahmed M. Rayan, Xiaoxiong Zeng
Summary: After in vitro gastrointestinal digestion and colonic fermentation, Moringa oleifera leaf polyphenols showed increased inhibitory activity against diabetes-related enzymes and positive effects on gut microbiota. However, the antioxidant and anti-tumor activities of the digested and fermented polyphenols were slightly reduced.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ana Garcia-Aguilar, Olga Palomino, Manuel Benito, Carlos Guillen
Summary: Polyphenols are secondary metabolites of plants that regulate various biological processes, offering protection against inflammation, oxidative stress, and related injuries. They promote autophagy, enhance mitochondrial function and antioxidant defenses, reduce oxidative stress, and decrease cell apoptosis, potentially explaining their health-promoting properties.
Article
Plant Sciences
Simone Angeloni, Eleonora Spinozzi, Filippo Maggi, Gianni Sagratini, Giovanni Caprioli, Germana Borsetta, Gunes Ak, Kouadio Ibrahime Sinan, Gokhan Zengin, Sabrina Arpini, Giacomo Mombelli, Massimo Ricciutelli
Summary: The study chemically characterized and tested enzyme inhibitory activity of extracts from L. cardiaca, finding that purified extracts have higher phytochemical content, with caffeoylmalic acid and verbascoside as the main components. There is a linear correlation between total phenolics, radical scavenging activity, and reducing power of the extracts, and compounds like quercetin and caffeic acid influence the bioactivities of the extracts.
Article
Biology
Susmit Mhatre, Shivraj Naik, Vandana Patravale
Summary: Tea polyphenols have shown potential in prophylaxis and treatment of COVID-19. Molecular docking studies revealed that tea polyphenols, especially Epigallocatechin gallate (EGCG) and Theaflavin digallate (TF3), interact well with possible targets of COVID-19, suggesting their promising in-silico activity for the treatment of the disease.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Food Science & Technology
Ayesha Noor, Musa Al Murad, A. Jaya Chitra, Spoorthy N. Babu, S. Govindarajan
Summary: This study focused on synthesizing microspheres of Piper betle polyphenols and evaluated the impact of alginate encapsulation on stability, bioavailability, and therapeutic properties. The results showed that encapsulation improved stability, increased bioavailability, and retained antioxidant and antidiabetic properties.
Article
Biochemistry & Molecular Biology
Jed Jebali, Hanene Ghazghazi, Chedia Aouadhi, Ines ELBini-Dhouib, Ridha Ben Salem, Najet Srairi-Abid, Naziha Marrakchi, Ghayth Rigane
Summary: This study investigated the biological activities of Mentha pulegium L. extracts from two different regions in Tunisia. The extracts exhibited varying levels of phenolic and flavonoid compounds, with the Bizerte locality showing the highest amounts. The extract from Bizerte also displayed the highest antioxidant activity, significant antimicrobial activity, and inhibited the proliferation of U87 human glioblastoma cells.
Article
Horticulture
Natasa Simin, Marija Lesjak, Nemanja Zivanovic, Biljana Bozanic Tanjga, Dejan Orcic, Mirjana Ljubojevic
Summary: This study found that six genotypes of edible roses have favorable aroma, rich phenolic compounds and vitamin C content, strong antioxidant activity, and moderate neuroprotective activity. The 'Marija Frayla' genotype stands out with the highest total phenolics content and strongest antioxidant activity, making it a valuable addition to the development of novel functional food products.
Review
Biochemistry & Molecular Biology
Ahmad Karami, Sajad Fakhri, Leila Kooshki, Haroon Khan
Summary: Polydatin is a natural polyphenol compound that possesses various important biological activities, such as anticancer and cardioprotective effects. This study reviews the therapeutic targets, biological activities, pharmacological mechanisms, and health benefits of polydatin, and suggests the need for further clinical trials and novel delivery systems.
Article
Multidisciplinary Sciences
Sara Volpes, Ilenia Cruciata, Federica Ceraulo, Chiara Schimmenti, Flores Naselli, Cecilia Pinna, Maurizio Mauro, Pasquale Picone, Sabrina Dallavalle, Domenico Nuzzo, Andrea Pinto, Fabio Caradonna
Summary: The aim of this study was to evaluate the biological effects of natural stilbenoids found in Vitis vinifera, with a focus on their activity as epigenetic modulators. Resveratrol, pterostilbene, and (+/-)-trans-pterostilbene dehydrodimer showed no toxic effects and were effective in reversing arsenic damage in Caco-2 cell lines. Further studies are needed to clarify the mode of action of (+/-)-trans-delta-viniferin.
SCIENTIFIC REPORTS
(2023)
Article
Agricultural Engineering
Wei Wu, Fu Xiang, Feng He
Summary: The study successfully utilized high hydrostatic pressure-assisted extraction (HPE) to extract polyphenols from Artemisia argyi leaf, resulting in a high extraction yield and efficiency. The extracted polyphenols displayed strong antioxidant properties, inhibition of biofilm formation, and antitumor activity, making HPE a promising environmentally friendly technology for polyphenol extraction from plant sources.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Plant Sciences
Somia Saad, Saida Ouafi, Hassina Meguellati, Nadjette Djemouai
Summary: The study analyzed the phytochemical composition of Marrubium deserti De Noe and evaluated the effects of various extracts on inflammation, pain response, and fever in animal models. Results showed that the plant exhibited anti-inflammatory, analgesic, and antipyretic activities.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)