Article
Cell & Tissue Engineering
Jialin He, Jianyang Liu, Yan Huang, Ziwei Lan, Xiangqi Tang, Zhiping Hu
Summary: This study comprehensively evaluated the effect of MSCs and MSCs-derived EVs in rodent models of SAH. The results showed that MSCs and MSCs-derived EVs significantly improved neurobehavioral score and reduced brain water content. However, significant heterogeneity among studies was observed, and further large animal studies and human trials are needed.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Eun Wha Choi, I. -Rang Lim, Ji Hong Park, Jiwoo Song, Bongkum Choi, Sungjoo Kim
Summary: Exosomes derived from disease-condition-serum-primed iMSCs showed potential in ameliorating cartilage damage in a RA model by enhancing TGF-beta 1 production, inducing Th2 and M2 polarization, and lowering proinflammatory cytokines levels. Patient-derived serum could be a valuable priming strategy for iMSC-derived exosome treatment of RA.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Biotechnology & Applied Microbiology
Bocheng Zhang, Xiaoyuan Tian, Zhenan Qu, Jiaming Liu, Liang Yang, Weiguo Zhang
Summary: Studies have shown that mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are more effective than placebo in treating osteoarthritis, especially in the early stages. Treatment once a week was found to be more effective than multiple times a week.
Article
Medicine, Research & Experimental
Huan Liu, Yuehong Chen, Geng Yin, Qibing Xie
Summary: Autoimmune diseases are chronic conditions with impaired self-tolerance, lacking effective treatment options. Mesenchymal stem cells release EVs and miRNAs that can modulate immune responses, offering potential therapeutic benefits but also facing challenges in clinical application.
Review
Cell & Tissue Engineering
Zhiping Wei, Jintao Yuan, Gaoying Wang, Dickson Kofi Wiredu Ocansey, Zhiwei Xu, Fei Mao
Summary: Research has shown that MSCs have potential therapeutic effects in autoimmune diseases. In addition to treating fractures and tissue repair, MSCs can help restore immune homeostasis by regulating T cell subsets.
STEM CELLS INTERNATIONAL
(2021)
Article
Immunology
Ke Rui, Yue Hong, Qiugang Zhu, Xiaofei Shi, Fan Xiao, Hailong Fu, Qing Yin, Yida Xing, Xinfeng Wu, Xiaodan Kong, Huaxi Xu, Jie Tian, Shengjun Wang, Liwei Lu
Summary: The study demonstrated that murine olfactory ecto-mesenchymal stem cell-derived exosomes can effectively attenuate the progression of experimental Sjogren's syndrome (ESS) by enhancing the immunosuppressive function of myeloid-derived suppressor cells (MDSCs). These exosomes activated the Jak2/Stat3 pathway in MDSCs through IL-6 secretion, and promoted the endogenous production of IL-6 via TLR4 signaling, indicating a potential autocrine pathway for MDSC functional modulation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Cell Biology
Yuexin Zhu, Manyu Luo, Xue Bai, Yan Lou, Ping Nie, Shan Jiang, Jicui Li, Bing Li, Ping Luo
Summary: Diabetic kidney disease is a serious complication of diabetes, and there are currently no effective drugs to prevent its progression. Mesenchymal stem cells have shown promise as a new treatment option for diabetic kidney disease, but their exact role and mechanism of action remain unclear.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Clinical Neurology
Andres Ramos-Fresnedo, Carlos Perez-Vega, Ricardo A. Domingo, Seung Jin Lee, Ralph B. Perkerson, Abba C. Zubair, Kanekiyo Takahisa, William Tatum, Alfredo Quinones-Hinojosa, Erik. H. Middlebrooks, Sanjeet S. Grewal
Summary: By systematically reviewing preclinical and clinical studies of MSCs for drug-resistant epilepsy, it was found that this therapy is safe and effective in reducing seizure burden, improving electrophysiological biomarkers, and alleviating comorbidities in patients. Further research is warranted to explore the full therapeutic potential of MSC therapy.
Review
Immunology
Jialin He, Yan Huang, Jianyang Liu, Ziwei Lan, Xiangqi Tang, Zhiping Hu
Summary: The study conducted a systematic review and meta-analysis of preclinical data on mesenchymal stem cell therapy for multiple sclerosis (MS) and found that MSC administration significantly improved functional recovery and promoted remyelination in rodent models of MS. Despite significant heterogeneity among studies, the overall positive effect of MSCs on functional outcomes and remyelination was evident in the analysis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Helena Ferreira, Diana Amorim, Ana Claudia Lima, Rogerio P. Pirraco, Ana Rita Costa-Pinto, Rui Almeida, Armando Almeida, Rui L. Reis, Filipa Pinto-Ribeiro, Nuno M. Neves
Summary: Stem cell therapies using a hydrogel as a cell carrier show potential in treating neurodegenerative diseases, with the engineered hydrogel demonstrating improved bioavailability of bone marrow mesenchymal stem cells. This approach may provide efficacious treatments for conditions such as multiple sclerosis.
Review
Immunology
Ziwei Shen, Wei Huang, Jun Liu, Jie Tian, Shengjun Wang, Ke Rui
Summary: Research indicates that mesenchymal stem cell-derived exosomes (MSC-EXOs) have a significant inhibitory effect on effector cells involved in the immune response, and can be used to treat various autoimmune diseases, serving as a promising cell-free treatment strategy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell & Tissue Engineering
Xintong Li, Hao Wen, Junyuan Lv, Boyang Luan, Jinze Meng, Shiqiang Gong, Jie Wen, Shijie Xin
Summary: This study conducted a meta-analysis and systematic review to assess the therapeutic efficacy of mesenchymal stem cells (MSCs) for abdominal aortic aneurysm (AAA). The results demonstrated that MSC intervention effectively suppresses aortic diameter enlargement, reduces elastin degradation, and modulates local immunoinflammatory reactions in AAA.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Yuchen Zhang, Naijun Dong, Huanle Hong, Jingxuan Qi, Shibo Zhang, Jiao Wang
Summary: Due to the aging population, stroke has become more prevalent, leading to increased socioeconomic burden. Stem cell transplantation, particularly using mesenchymal stem cells (MSCs), has shown promise in treating stroke by attenuating inflammation, promoting therapeutic effects, inducing blood vessel formation, promoting neurogenesis, reducing infarct volume, and replacing damaged cells. This review discusses the mechanisms of MSCs and their secreted extracellular vehicles (EVs) in stroke treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Ya Yang, Yalei Zhao, Lingjian Zhang, Fen Zhang, Lanjuan Li
Summary: Mesenchymal stem cell (MSC) transplantation is a novel treatment for liver diseases, but the mechanisms are not fully understood. Despite significant efficacy in animal models and preliminary clinical trials, issues such as efficacy and safety remain. Therefore, more research is needed to address the challenging issues of MSC-based therapy in the treatment of liver diseases.
FRONTIERS IN MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Joshua Richard Burke, Jack Helliwell, Jason Wong, Aaron Quyn, Sarah Herrick, David Jayne
Summary: Mesenchymal stem cell delivery to an animal anastomosis is safe and feasible, but current findings are limited to surrogate histological outcomes. There is consistency in reported outcome measures, but variance in assessment methods. Compliance with ARRIVE guidelines is poor, but compliance with current international consensus in colon leak models is good.
COLORECTAL DISEASE
(2021)
