Biomarkers in systemic lupus erythematosus: challenges and prospects for the future

Low Level of Serum Interleukin 27 in Patients With Systemic Lupus Erythematosus: TABLE 1.

(2016) Ting-Ting Li et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Excessive Production of IFN-  in Patients with Systemic Lupus Erythematosus and Its Contribution to Induction of B Lymphocyte Stimulator/B Cell-Activating Factor/TNF Ligand Superfamily-13B

(2014) M. Harigai et al.   JOURNAL OF IMMUNOLOGY

Cholera Toxin B Accelerates Disease Progression in Lupus-Prone Mice by Promoting Lipid Raft Aggregation

(2014) G.-M. Deng et al.   JOURNAL OF IMMUNOLOGY

Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

(2014) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

Potent Induction of IFN-  and Chemokines by Autoantibodies in the Cerebrospinal Fluid of Patients with Neuropsychiatric Lupus

(2014) D. M. Santer et al.   JOURNAL OF IMMUNOLOGY

Measurement of cell-bound complement activation products enhances diagnostic performance in systemic lupus erythematosus

(2012) Kenneth C. Kalunian et al.   ARTHRITIS AND RHEUMATISM

Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis

(2012) Hermine I. Brunner et al.   ARTHRITIS AND RHEUMATISM

Anti-C1q antibody is a valuable biological marker for prediction of renal pathological characteristics in lupus nephritis

(2012) Zhu Chen et al.   CLINICAL RHEUMATOLOGY

Type I IFN system in the development and manifestations of SLE

(2012) Keith B. Elkon et al.   CURRENT OPINION IN RHEUMATOLOGY

Biomarkers for systemic lupus erythematosus

(2012) Ronald Herbst et al.   International Journal of Rheumatic Diseases

Urinary Neutrophil Gelatinase-Associated Lipocalin Is a Potential Biomarker for Renal Damage in Patients with Systemic Lupus Erythematosus

(2012) Chun-Chen Yang et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Urinary Vascular Cell Adhesion Molecule, But Not Neutrophil Gelatinase-associated Lipocalin, Is Associated with Lupus Nephritis

(2012) A. N. KIANI et al.   JOURNAL OF RHEUMATOLOGY

An epigenetic silencing pathway controlling T helper 2 cell lineage commitment

(2012) Rhys S. Allan et al.   NATURE

New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?

(2012) Karolin Luger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNAs—novel regulators of systemic lupus erythematosus pathogenesis

(2012) Nan Shen et al.   Nature Reviews Rheumatology

Biomarkers for systemic lupus erythematosus

(2012) Joseph M. Ahearn et al.   Translational Research

Circulating microRNAs as candidate biomarkers in patients with systemic lupus erythematosus

(2012) Honglei Wang et al.   Translational Research

Use of type I interferon-inducible mRNAs as pharmacodynamic markers and potential diagnostic markers in trials with sifalimumab, an anti-IFNα antibody, in systemic lupus erythematosus

(2012) Yihong Yao et al.   ARTHRITIS RESEARCH & THERAPY

Safety profile and clinical activity of sifalimumab, a fully human anti-interferon   monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study

(2011) J. T. Merrill et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression

(2011) E. Stagakis et al.   ANNALS OF THE RHEUMATIC DISEASES

B lymphocyte stimulator levels in systemic lupus erythematosus: Higher circulating levels in African American patients and increased production after influenza vaccination in patients with low baseline levels

(2011) Lauren L. Ritterhouse et al.   ARTHRITIS AND RHEUMATISM

Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus

(2011) Matlock Jeffries et al.   Epigenetics

Recent advances in the genetics of systemic lupus erythematosus

(2011) Donna L Thibault Flesher et al.   Expert Review of Clinical Immunology

Histones and genome integrity

(2011) Wes et al.   Frontiers in Bioscience-Landmark

A whole genome methylation analysis of systemic lupus erythematosus: hypomethylation of the IL10 and IL1R2 promoters is associated with disease activity

(2011) S-Y Lin et al.   GENES AND IMMUNITY

Activation of Type I Interferon Pathway in Systemic Lupus Erythematosus: Association with Distinct Clinical Phenotypes

(2011) Theophanis P. Karageorgas et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The Dysregulation of Cytokine Networks in Systemic Lupus Erythematosus

(2011) Sokratis A. Apostolidis et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The Role of Cytokines in the Pathogenesis and Treatment of Systemic Lupus Erythematosus

(2011) Laurie S. Davis et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

A composite urine biomarker reflects interstitial inflammation in lupus nephritis kidney biopsies

(2011) Xiaolan Zhang et al.   KIDNEY INTERNATIONAL

Prospective assessment of C4d deposits on circulating cells and renal tissues in lupus nephritis: a pilot study

(2011) I Batal et al.   LUPUS

Antinucleosome antibodies as a potential biomarker for the evaluation of renal pathological activity in patients with proliferative lupus nephritis

(2011) WT Hung et al.   LUPUS

Urinary monocyte chemoattractant protein 1 and alpha 1 acid glycoprotein as biomarkers of renal disease activity in juvenile-onset systemic lupus erythematosus

(2011) L Watson et al.   LUPUS

Anti-C1q antibodies have higher correlation with flares of lupus nephritis than other serum markers

(2011) E Akhter et al.   LUPUS

The role of cytokines as biomarkers in systemic lupus erythematosus and lupus nephritis

(2011) Z. Adhya et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Copy number variations of Interleukin-12B and T-bet are associated with systemic lupus erythematosus

(2011) Bo Yu et al.   RHEUMATOLOGY

MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases

(2011) Rujuan Dai et al.   Translational Research

Abnormalities of T cell signaling in systemic lupus erythematosus

(2011) Vaishali R Moulton et al.   ARTHRITIS RESEARCH & THERAPY

The role of epigenetic variation in the pathogenesis of systemic lupus erythematosus

(2011) Travis Hughes et al.   ARTHRITIS RESEARCH & THERAPY

Regulation of mRNA Translation and Stability by microRNAs

(2010) Marc Robert Fabian et al.   Annual Review of Biochemistry

MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus

(2010) Xia Zhao et al.   ARTHRITIS AND RHEUMATISM

Expression of CD44 variant isoforms CD44v3 and CD44v6 is increased on T cells from patients with systemic lupus erythematosus and is correlated with disease activity

(2010) José C. Crispín et al.   ARTHRITIS AND RHEUMATISM

MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1

(2010) Sha Zhao et al.   ARTHRITIS AND RHEUMATISM

The Unexplained Female Predominance of Systemic Lupus Erythematosus: Clues from Genetic and Cytokine Studies

(2010) Corinna E. Weckerle et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Interleukin-17-producing T cells in lupus

(2010) José C Crispín et al.   CURRENT OPINION IN RHEUMATOLOGY

DNA methylome in human CD4+ T cells identifies transcriptionally repressive and non-repressive methylation peaks

(2010) T Hughes et al.   GENES AND IMMUNITY

Dynamic changes in the human methylome during differentiation

(2010) L. Laurent et al.   GENOME RESEARCH

IL-17 in Systemic Lupus Erythematosus

(2010) José C. Crispín et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Increased Expression of Ganglioside GM1 in Peripheral CD4+ T Cells Correlates Soluble Form of CD30 in Systemic Lupus Erythematosus Patients

(2010) Lingli Dong et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Hypomethylation ofIL10andIL13Promoters in CD4+T Cells of Patients with Systemic Lupus Erythematosus

(2010) Ming Zhao et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Biomarkers for Lupus Nephritis: A Critical Appraisal

(2010) Chi Chiu Mok   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

MicroRNA-21 and MicroRNA-148a Contribute to DNA Hypomethylation in Lupus CD4+ T Cells by Directly and Indirectly Targeting DNA Methyltransferase 1

(2010) W. Pan et al.   JOURNAL OF IMMUNOLOGY

Serum and Urinary Cell-free MiR-146a and MiR-155 in Patients with Systemic Lupus Erythematosus

(2010) G. WANG et al.   JOURNAL OF RHEUMATOLOGY

Simultaneous detection of anti-C1q and anti-double stranded DNA autoantibodies in lupus nephritis: predictive value for renal flares

(2010) A Matrat et al.   LUPUS

A systemic lupus erythematosus gene expression array in disease diagnosis and classification: a preliminary report

(2010) Y-T Juang et al.   LUPUS

The interferon-α signature of systemic lupus erythematosus

(2010) G. Obermoser et al.   LUPUS

A CD8+ T cell transcription signature predicts prognosis in autoimmune disease

(2010) Eoin F McKinney et al.   NATURE MEDICINE

Are anti-C1q antibodies different from other SLE autoantibodies?

(2010) Matthew C. Pickering et al.   Nature Reviews Rheumatology

Genetic susceptibility to systemic lupus erythematosus in the genomic era

(2010) Yun Deng et al.   Nature Reviews Rheumatology

Identification of Unique MicroRNA Signature Associated with Lupus Nephritis

(2010) Jeannie L. Te et al.   PLoS One

Cell-Bound Complement Biomarkers for Systemic Lupus Erythematosus: From Benchtop to Bedside

(2010) Chau-Ching Liu et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Urinary neutrophil gelatinase-associated lipocalin as a novel biomarker for disease activity in lupus nephritis

(2010) T. Rubinstein et al.   RHEUMATOLOGY

Pathogenesis of human systemic lupus erythematosus: recent advances

(2010) José C. Crispín et al.   TRENDS IN MOLECULAR MEDICINE

Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus

(2010) Kamini Shah et al.   ARTHRITIS RESEARCH & THERAPY

Anti-C1q Autoantibodies in Lupus Nephritis

(2009) Renato Alberto Sinico et al.   Annals of the New York Academy of Sciences

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: A validation study

(2009) Jason W. Bauer et al.   ARTHRITIS AND RHEUMATISM

Neutrophil gelatinase-associated lipocalin is a predictor of the course of global and renal childhood-onset systemic lupus erythematosus disease activity

(2009) Claas H. Hinze et al.   ARTHRITIS AND RHEUMATISM

MicroRNA-146a contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins

(2009) Yuanjia Tang et al.   ARTHRITIS AND RHEUMATISM

Th17 and natural Treg cell population dynamics in systemic lupus erythematosus

(2009) Ji Yang et al.   ARTHRITIS AND RHEUMATISM

MicroRNA Control in the Immune System: Basic Principles

(2009) Changchun Xiao et al.   CELL

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Biomarkers for Lupus Nephritis: The Quest Continues

(2009) B. H. Rovin et al.   Clinical Journal of the American Society of Nephrology

TNF-like weak inducer of apoptosis (TWEAK) induces inflammatory and proliferative effects in human kidney cells

(2009) Hua-Xin Gao et al.   CYTOKINE

IL-17-producing γδ T cells

(2009) Rebecca L. O'Brien et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Global H4 acetylation analysis by ChIP-chip in systemic lupus erythematosus monocytes

(2009) Z Zhang et al.   GENES AND IMMUNITY

Recent insights into the genetic basis of systemic lupus erythematosus

(2009) K L Moser et al.   GENES AND IMMUNITY

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

(2009) B. M. Javierre et al.   GENOME RESEARCH

Normally occurring NKG2D+CD4+T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus

(2009) Zhenpeng Dai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Role of IL-23/IL-17 Axis in Lupus Nephritis

(2009) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

Stimulatory and Inhibitory Killer Ig-Like Receptor Molecules Are Expressed and Functional on Lupus T Cells

(2009) D. Basu et al.   JOURNAL OF IMMUNOLOGY

Urine Osteoprotegerin and Monocyte Chemoattractant Protein-1 in Lupus Nephritis

(2009) A. N. KIANI et al.   JOURNAL OF RHEUMATOLOGY

Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus

(2009) M Petri et al.   LUPUS

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Interleukin 17 acts in synergy with B cell–activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus

(2009) Agnès Doreau et al.   NATURE IMMUNOLOGY

Initial Validation of a Novel Protein Biomarker Panel for Active Pediatric Lupus Nephritis

(2009) Michiko Suzuki et al.   PEDIATRIC RESEARCH

A human B cell methylome at 100−base pair resolution

(2009) Tibor A. Rauch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-C1q antibodies antedate patent active glomerulonephritis in patients with systemic lupus erythematosus

(2009) Olivier C Meyer et al.   ARTHRITIS RESEARCH & THERAPY

Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study

(2009) Jessica J Manson et al.   ARTHRITIS RESEARCH & THERAPY

Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study

(2009) Noa Schwartz et al.   ARTHRITIS RESEARCH & THERAPY

The biological and clinical importance of the 'new generation' cytokines in rheumatic diseases

(2009) Cem Gabay et al.   ARTHRITIS RESEARCH & THERAPY

Antinucleosome Antibodies as a Marker of Active Proliferative Lupus Nephritis

(2008) Cornelia Bigler et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Neutrophil Gelatinase–Associated Lipocalin (NGAL) as a Marker of Kidney Damage

(2008) Davide Bolignano et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Lack of association between the interferon-  signature and longitudinal changes in disease activity in systemic lupus erythematosus

(2008) C Landolt-Marticorena et al.   ANNALS OF THE RHEUMATIC DISEASES

Are laboratory tests useful for monitoring the activity of lupus nephritis? A 6-year prospective study in a cohort of 228 patients with lupus nephritis

(2008) G Moroni et al.   ANNALS OF THE RHEUMATIC DISEASES

Potential for glomerular C4d as an indicator of thrombotic microangiopathy in lupus nephritis

(2008) Danielle Cohen et al.   ARTHRITIS AND RHEUMATISM

Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus

(2008) Michelle Petri et al.   ARTHRITIS AND RHEUMATISM

Sialic acid-binding Ig-like lectin 1 expression in inflammatory and resident monocytes is a potential biomarker for monitoring disease activity and success of therapy in systemic lupus erythematosus

(2008) Robert Biesen et al.   ARTHRITIS AND RHEUMATISM

Anti-chromatin (anti-nucleosome) antibodies: Diagnostic and clinical value

(2008) José A. Gómez-Puerta et al.   AUTOIMMUNITY REVIEWS

DNA methylation inhibition increases T cell KIR expression through effects on both promoter methylation and transcription factors

(2008) Ying Liu et al.   CLINICAL IMMUNOLOGY

Lipid rafts and T-lymphocyte function: Implications for autoimmunity

(2008) Panagiotis S. Kabouridis et al.   FEBS LETTERS

The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation

(2008) Wenjun Ouyang et al.   IMMUNITY

The role of IL-21 in regulating B-cell function in health and disease

(2008) Rachel Ettinger et al.   IMMUNOLOGICAL REVIEWS

The Cytokine TWEAK Modulates Renal Tubulointerstitial Inflammation

(2008) A. B. Sanz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

MicroRNAs: new regulators of immune cell development and function

(2008) David Baltimore et al.   NATURE IMMUNOLOGY

The TWEAK–Fn14 cytokine–receptor axis: discovery, biology and therapeutic targeting

(2008) Jeffrey A. Winkles   NATURE REVIEWS DRUG DISCOVERY

Systemic Lupus Erythematosus

(2008) Anisur Rahman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophil gelatinase-associated lipocalin as a biomarker of disease activity in pediatric lupus nephritis

(2008) Michiko Suzuki et al.   PEDIATRIC NEPHROLOGY

Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients

(2008) Yong Dai et al.   RHEUMATOLOGY INTERNATIONAL

Complement Component C1q and Anti-C1q Antibodies in Theory and in Clinical Practice

(2008) E. Potlukova et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Association of a gene expression profile from whole blood with disease activity in systemic lupus erythaematosus

(2007) M Nikpour et al.   ANNALS OF THE RHEUMATIC DISEASES