Neurotrauma and mesenchymal stem cells treatment: From experimental studies to clinical trials

Comparison of functional and histological outcomes after intralesional, intracisternal, and intravenous transplantation of human bone marrow-derived mesenchymal stromal cells in a rat model of spinal cord injury

(2013) Dong Ah Shin et al.   ACTA NEUROCHIRURGICA

Transplantation of autologous bone marrow mesenchymal stem cells in the treatment of complete and chronic cervical spinal cord injury

(2013) Guanghui Dai et al.   BRAIN RESEARCH

Mesenchymal bone marrow stem cells within polyglycolic acid tube observed in vivo after six weeks enhance facial nerve regeneration

(2013) Heloisa Juliana Zabeu Rossi Costa et al.   BRAIN RESEARCH

Transplantation of Human Umbilical Cord Blood or Amniotic Epithelial Stem Cells Alleviates Mechanical Allodynia after Spinal Cord Injury in Rats

(2013) Dae-Hyun Roh et al.   CELL TRANSPLANTATION

Improvement in Nerve Regeneration through a Decellularized Nerve Graft by Supplementation with Bone Marrow Stromal Cells in Fibrin

(2013) Zhe Zhao et al.   CELL TRANSPLANTATION

Comparison of mesenchymal stromal cells from human bone marrow and adipose tissue for the treatment of spinal cord injury

(2013) Zhilai Zhou et al.   CYTOTHERAPY

A comparison of the behavioral and anatomical outcomes in sub-acute and chronic spinal cord injury models following treatment with human mesenchymal precursor cell transplantation and recombinant decorin

(2013) Stuart I. Hodgetts et al.   EXPERIMENTAL NEUROLOGY

Combination of fibrin-agarose hydrogels and adipose-derived mesenchymal stem cells for peripheral nerve regeneration

(2013) Víctor Carriel et al.   Journal of Neural Engineering

Spinal Cord Injury: A Review of Current Therapy, Future Treatments, and Basic Science Frontiers

(2013) Abhay K. Varma et al.   NEUROCHEMICAL RESEARCH

Neuroprotection and Axonal Regeneration After Lumbar Ventral Root Avulsion by Re-implantation and Mesenchymal Stem Cells Transplant Combined Therapy

(2013) Abel Torres-Espín et al.   Neurotherapeutics

Bone Marrow–Derived Mesenchymal Stem Cell Transplantation for Chronic Spinal Cord Injury in Rats

(2013) Jang-Woon Kim et al.   SPINE

Mesenchymal Cells in the Treatment of Spinal Cord Injury: Current & Future Perspectives

(2013) Reaz Vawda et al.   Current Stem Cell Research & Therapy

Preclinical evaluations of acellular biological conduits for peripheral nerve regeneration

(2013) I-Chien Liao et al.   Journal of Tissue Engineering

Regeneration of peripheral nerves by transplanted sphere of human mesenchymal stem cells derived from embryonic stem cells

(2012) Eun Ju Lee et al.   BIOMATERIALS

Tissue engineered regeneration of completely transected spinal cord using human mesenchymal stem cells

(2012) Kkot Nim Kang et al.   BIOMATERIALS

Long-term outcome of the repair of 50 mm long median nerve defects in rhesus monkeys with marrow mesenchymal stem cells-containing, chitosan-based tissue engineered nerve grafts

(2012) Nan Hu et al.   BIOMATERIALS

A combination of taxol infusion and human umbilical cord mesenchymal stem cells transplantation for the treatment of rat spinal cord injury

(2012) Zhou Zhilai et al.   BRAIN RESEARCH

Clinical safety and primary efficacy of bone marrow mesenchymal cell transplantation in subacute spinal cord injured patients

(2012) Saeid Karamouzian et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Traumatic Spinal Cord Injury Alters Angiogenic Factors and TGF-Beta1 that may Affect Vascular Recovery

(2012) Marie-Francoise Ritz et al.   CURRENT NEUROVASCULAR RESEARCH

Protein profiling of anastomosed facial nerve treated with mesenchymal stromal cells

(2012) Bulent Satar et al.   CYTOTHERAPY

Functional recovery after spinal cord injury in dogs treated with a combination of Matrigel and neural-induced adipose-derived mesenchymal Stem cells

(2012) Sung-Su Park et al.   CYTOTHERAPY

Use of poly(DL-lactide-ε-caprolactone) membranes and mesenchymal stem cells from the Wharton's jelly of the umbilical cord for promoting nerve regeneration in axonotmesis: In vitro and in vivo analysis

(2012) A. Gärtner et al.   DIFFERENTIATION

17β-Estradiol Attenuates Neural Cell Apoptosis Through Inhibition of JNK Phosphorylation in SCI Rats and Excitotoxicity Induced by Glutamate In Vitro

(2012) Wei Rong et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell Therapy Promotes Functional Recovery of Contused Rat Spinal Cord through Enhancement of Endogenous Cell Proliferation and Oligogenesis

(2012) Sang In Park et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Fate of Transplanted Bone Marrow Derived Mesenchymal Stem Cells Following Spinal Cord Injury in Rats by Transplantation Routes

(2012) Eun-Sun Kang et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Enhancement of nerve regeneration along a chitosan conduit combined with bone marrow mesenchymal stem cells

(2012) Lei Zheng et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Facial Nerve Repair With Gore-Tex Tube and Adipose-Derived Stem Cells: An Animal Study in Dogs

(2012) Mehdi Ghoreishian et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Natural conduits for bridging a 15-mm nerve defect: Comparison of the vein supported by muscle and bone marrow stromal cells with a nerve autograft

(2012) Tim H.J. Nijhuis et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Neuroprotective effects of adipose-derived stem cells against ischemic neuronal damage in the rabbit spinal cord

(2012) Jin Young Chung et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Effects of Human Mesenchymal Stem Cell Transplantation Combined with Polymer on Functional Recovery Following Spinal Cord Hemisection in Rats

(2012) Ji Soo Choi et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Transplantation of an adipose stem cell cluster in a spinal cord injury

(2012) Jin Soo Oh et al.   NEUROREPORT

Fibrin conduit supplemented with human mesenchymal stem cells and immunosuppressive treatment enhances regeneration after peripheral nerve injury

(2012) Aleksandra M. McGrath et al.   NEUROSCIENCE LETTERS

Recellularized nerve allografts with differentiated mesenchymal stem cells promote peripheral nerve regeneration

(2012) Yu Wang et al.   NEUROSCIENCE LETTERS

A Systematic Review of Nerve Transfer and Nerve Repair for the Treatment of Adult Upper Brachial Plexus Injury

(2012) Lynda J.-S. Yang et al.   NEUROSURGERY

Mesenchymal Stem Cell Graft Improves Recovery after Spinal Cord Injury in Adult Rats through Neurotrophic and Pro-Angiogenic Actions

(2012) Renaud Quertainmont et al.   PLoS One

Mesenchymal Stem Cells in a Polycaprolactone Conduit Promote Sciatic Nerve Regeneration and Sensory Neuron Survival after Nerve Injury

(2012) Flávia Frattini et al.   TISSUE ENGINEERING PART A

Human Adipose-Derived Mesenchymal Stem Cells Systemically Injected Promote Peripheral Nerve Regeneration in the Mouse Model of Sciatic Crush

(2012) Silvia Marconi et al.   TISSUE ENGINEERING PART A

Reduction of lesion in injured rat spinal cord and partial functional recovery of motility after bone marrow derived mesenchymal stem cell transplantation

(2012) Erdal Karaoz et al.   Turkish Neurosurgery

Periprostatic Implantation of Human Bone Marrow-derived Mesenchymal Stem Cells Potentiates Recovery of Erectile Function by Intracavernosal Injection in a Rat Model of Cavernous Nerve Injury

(2012) Dalsan You et al.   UROLOGY

Mesenchymal Stem Cell Transplantation Reduces Glial Cyst and Improves Functional Outcome After Spinal Cord Compression

(2012) Marina Boido et al.   World Neurosurgery

Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction

(2011) Petr Dubový   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Antioxidant therapies in traumatic brain and spinal cord injury

(2011) Mona Bains et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Significant clinical, neuropathological and behavioural recovery from acute spinal cord trauma by transplantation of a well-defined somatic stem cell from human umbilical cord blood

(2011) Jessica Schira et al.   BRAIN

NT-3-secreting human umbilical cord mesenchymal stromal cell transplantation for the treatment of acute spinal cord injury in rats

(2011) Ai-Jia Shang et al.   BRAIN RESEARCH

Schwann-like mesenchymal stem cells within vein graft facilitate facial nerve regeneration and remyelination

(2011) Xuemei Wang et al.   BRAIN RESEARCH

Comparison of Canine Umbilical Cord Blood-Derived Mesenchymal Stem Cell Transplantation Times: Involvement of Astrogliosis, Inflammation, Intracellular Actin Cytoskeleton Pathways, and Neurotrophin-3

(2011) Sung-Su Park et al.   CELL TRANSPLANTATION

Bone Marrow Mesenchymal Stem Cells in a Three-Dimensional Gelatin Sponge Scaffold Attenuate Inflammation, Promote Angiogenesis, and Reduce Cavity Formation in Experimental Spinal Cord Injury

(2011) Xiang Zeng et al.   CELL TRANSPLANTATION

Transplantation of Predifferentiated Adipose-Derived Stromal Cells for the Treatment of Spinal Cord Injury

(2011) David Arboleda et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Synergistic Effects of Bone Mesenchymal Stem Cells and Chondroitinase ABC on Nerve Regeneration After Acellular Nerve Allograft in Rats

(2011) Ying Wang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neuroprotective and growth-promoting effects of bone marrow stromal cells after cervical spinal cord injury in adult rats

(2011) Liudmila N. Novikova et al.   CYTOTHERAPY

In vivo MRI monitoring nerve regeneration of acute peripheral nerve traction injury following mesenchymal stem cell transplantation

(2011) Xiao-Hui Duan et al.   EUROPEAN JOURNAL OF RADIOLOGY

Differentiation of mesenchymal stem cells to support peripheral nerve regeneration in a rat model

(2011) A. Ladak et al.   EXPERIMENTAL NEUROLOGY

Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury

(2011) Andrew D Gaudet et al.   Journal of Neuroinflammation

Human Dental Pulp Cells: A New Source of Cell Therapy in a Mouse Model of Compressive Spinal Cord Injury

(2011) Fernanda Martins de Almeida et al.   JOURNAL OF NEUROTRAUMA

Combined VEGF and PDGF Treatment Reduces Secondary Degeneration after Spinal Cord Injury

(2011) Cameron Lutton et al.   JOURNAL OF NEUROTRAUMA

New treatment for peripheral nerve defects: Reconstruction of a 2 cm, monkey median nerve gap by direct lengthening of both nerve stumps

(2011) Yuki Hara et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Repair of nerve defect with acellular nerve graft supplemented by bone marrow stromal cells in mice

(2011) Zhe Zhao et al.   MICROSURGERY

Bone marrow-derived mesenchymal stem cells expressing the bFGF transgene promote axon regeneration and functional recovery after spinal cord injury in rats

(2011) Wen-Ge Liu et al.   NEUROLOGICAL RESEARCH

The efficacy of antioxidants in functional recovery of spinal cord injured rats: an experimental study

(2011) Asirvatham Alwin Robert et al.   NEUROLOGICAL SCIENCES

Delayed neuroprotection by riluzole against excitotoxic damage evoked by kainate on rat organotypic spinal cord cultures

(2011) G.L. Mazzone et al.   NEUROSCIENCE

Long-term Results of Spinal Cord Injury Therapy Using Mesenchymal Stem Cells Derived From Bone Marrow in Humans

(2011) Jin Hoon Park et al.   NEUROSURGERY

Inhibition of Cysteine Proteases in Acute and Chronic Spinal Cord Injury

(2011) Swapan K. Ray et al.   Neurotherapeutics

Differentiated Mesenchymal Stem Cells for Sciatic Nerve Injury

(2011) Michal Dadon-Nachum et al.   Stem Cell Reviews and Reports

Sciatic nerve repair by acellular nerve xenografts implanted with BMSCs in rats xenograft combined with BMSCs

(2011) Hua Jia et al.   SYNAPSE

Repair of Rat Sciatic Nerve Gap by a Silk Fibroin-Based Scaffold Added with Bone Marrow Mesenchymal Stem Cells

(2011) Yumin Yang et al.   TISSUE ENGINEERING PART A

A nerve graft constructed with xenogeneic acellular nerve matrix and autologous adipose-derived mesenchymal stem cells

(2010) Yongjie Zhang et al.   BIOMATERIALS

The regeneration of transected sciatic nerves of adult rats using chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwann cells

(2010) Qiang Ao et al.   BIOMATERIALS

The effect of mesenchymal stem cell transplantation on the recovery of bladder and hindlimb function after spinal cord contusion in rats

(2010) Won Park et al.   BMC NEUROSCIENCE

Implantation of adult bone marrow-derived mesenchymal stem cells transfected with the neurotrophin-3 gene and pretreated with retinoic acid in completely transected spinal cord

(2010) Wei Zhang et al.   BRAIN RESEARCH

Predifferentiated embryonic stem cells promote functional recovery after spinal cord compressive injury

(2010) Suelen Adriani Marques et al.   BRAIN RESEARCH

Intravenous administration of mesenchymal stem cells derived from bone marrow after contusive spinal cord injury improves functional outcome

(2010) Misuzu Osaka et al.   BRAIN RESEARCH

Functional recovery in acute traumatic spinal cord injury after transplantation of human umbilical cord mesenchymal stem cells

(2010) Sheng-Li Hu et al.   CRITICAL CARE MEDICINE

Mesenchymal Stem Cells for Treatment of CNS Injury

(2010) Michael F. Azari et al.   Current Neuropharmacology

Functional recovery after transplantation of bone marrow-derived human mesenchymal stromal cells in a rat model of spinal cord injury

(2010) Rakhi Pal et al.   CYTOTHERAPY

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases

(2010) K. A. Jellinger   EUROPEAN JOURNAL OF NEUROLOGY

Measuring nerve regeneration in the mouse

(2010) John W. Griffin et al.   EXPERIMENTAL NEUROLOGY

Estrogen receptor agonists and estrogen attenuate TNF- -induced apoptosis in VSC4.1 motoneurons

(2010) A. Das et al.   JOURNAL OF ENDOCRINOLOGY

In vivo MR imaging tracking of transplanted mesenchymal stem cells in a rabbit model of acute peripheral nerve traction injury

(2010) Jun Shen et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Use of chitosan conduit combined with bone marrow mesenchymal stem cells for promoting peripheral nerve regeneration

(2010) Lei Zheng et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Human Umbilical Cord-Derived Mesenchymal Stromal Cells Differentiate Into Functional Schwann Cells That Sustain Peripheral Nerve Regeneration

(2010) Dai Matsuse et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Repetitive Intrathecal Catheter Delivery of Bone Marrow Mesenchymal Stromal Cells Improves Functional Recovery in a Rat Model of Contusive Spinal Cord Injury

(2010) Dasa Cizkova et al.   JOURNAL OF NEUROTRAUMA

A Systematic Review of Cellular Transplantation Therapies for Spinal Cord Injury

(2010) Wolfram Tetzlaff et al.   JOURNAL OF NEUROTRAUMA

Schwann cell-like remyelination following transplantation of human umbilical cord blood (hUCB)-derived mesenchymal stem cells in dogs with acute spinal cord injury

(2010) Jae-Hoon Lee et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Effect of neural-induced mesenchymal stem cells and platelet-rich plasma on facial nerve regeneration in an acute nerve injury model

(2010) Hyong-Ho Cho et al.   LARYNGOSCOPE

Mesenchymal stem cells in a polycaprolactone conduit enhance median-nerve regeneration, prevent decrease of creatine phosphokinase levels in muscle, and improve functional recovery in mice

(2010) J.T. Oliveira et al.   NEUROSCIENCE

Hypoxia-preconditioned adipose tissue-derived mesenchymal stem cell increase the survival and gene expression of engineered neural stem cells in a spinal cord injury model

(2010) Jin Soo Oh et al.   NEUROSCIENCE LETTERS

Effects of Combinatorial Treatment with Pituitary Adenylate Cyclase Activating Peptide and Human Mesenchymal Stem Cells on Spinal Cord Tissue Repair

(2010) Kuan-Min Fang et al.   PLoS One

Repairing injured peripheral nerves: Bridging the gap

(2010) Ronald Deumens et al.   PROGRESS IN NEUROBIOLOGY

Development of Complete Thoracic Spinal Cord Transection Model in Rats for Delayed Transplantation of Stem Cells

(2010) Sang Hyuk Min et al.   SPINE

Concise Review: Bone Marrow for the Treatment of Spinal Cord Injury: Mechanisms and Clinical Applications

(2010) Karina T. Wright et al.   STEM CELLS

HPMA-RGD Hydrogels Seeded with Mesenchymal Stem Cells Improve Functional Outcome in Chronic Spinal Cord Injury

(2010) Aleš Hejčl et al.   STEM CELLS AND DEVELOPMENT

Use of Tissue-Engineered Nerve Grafts Consisting of a Chitosan/Poly(lactic-co-glycolic acid)-Based Scaffold Included with Bone Marrow Mesenchymal Cells for Bridging 50-mm Dog Sciatic Nerve Gaps

(2010) Fei Ding et al.   TISSUE ENGINEERING PART A

Bone marrow mesenchymal stem cells promote cell proliferation and neurotrophic function of Schwann cells in vitro and in vivo

(2009) Jie Wang et al.   BRAIN RESEARCH

Effects of Differentiated Versus Undifferentiated Adipose Tissue-derived Stromal Cell Grafts on Functional Recovery After Spinal Cord Contusion

(2009) Hong-Tian Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Proteasome inhibition suppresses Schwann cell dedifferentiationin vitroandin vivo

(2009) Hyun Kyoung Lee et al.   GLIA

Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis

(2009) Lianhua Bai et al.   GLIA

Neurotrophic Actions of Bone Marrow Stromal Cells on Primary Culture of Dorsal Root Ganglion Tissues and Neurons

(2009) Yun Gu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Enhancement of regeneration with glia cell line–derived neurotrophic factor–transduced human amniotic fluid mesenchymal stem cells after sciatic nerve crush injury [RETRACTED]

(2009) Fu-Chou Cheng et al.   JOURNAL OF NEUROSURGERY

Functional recovery and neural differentiation after transplantation of allogenic adipose-derived stem cells in a canine model of acute spinal cord injury

(2009) Hak-Hyun Ryu et al.   Journal of Veterinary Science

Transplantation of bone marrow mesenchymal stem cells reduces lesion volume and induces axonal regrowth of injured spinal cord

(2009) Weidong Gu et al.   NEUROPATHOLOGY

Trophic activity derived from bone marrow mononuclear cells increases peripheral nerve regeneration by acting on both neuronal and glial cell populations

(2009) V.T. Ribeiro-Resende et al.   NEUROSCIENCE

The role of neurotrophic factors in nerve regeneration

(2009) Tessa Gordon   Neurosurgical Focus

Transplantation of a combination of autologous neural differentiated and undifferentiated mesenchymal stem cells into injured spinal cord of rats

(2009) M S Pedram et al.   SPINAL CORD

Long-Term Survival and Integration of Transplanted Engineered Nervous Tissue Constructs Promotes Peripheral Nerve Regeneration

(2009) Jason H. Huang et al.   TISSUE ENGINEERING PART A

Co-transplantation of bFGF-expressing amniotic epithelial cells and neural stem cells promotes functional recovery in spinal cord-injured rats

(2008) X MENG et al.   CELL BIOLOGY INTERNATIONAL

Characterization of mesenchymal stromal cells derived from full-term umbilical cord blood

(2008) M.F. Manca et al.   CYTOTHERAPY

Can Local Supply of Bone Marrow Mononuclear Cells Improve the Outcome from Late Tubular Repair of Human Median and Ulnar Nerves?

(2008) J. BRAGA-SILVA et al.   Journal of Hand Surgery-European Volume

Melatonin attenuates calpain upregulation, axonal damage and neuronal death in spinal cord injury in rats

(2008) Supriti Samantaray et al.   JOURNAL OF PINEAL RESEARCH

Transplantation of Human Umbilical Mesenchymal Stem Cells from Wharton's Jelly after Complete Transection of the Rat Spinal Cord

(2008) Chang-Ching Yang et al.   PLoS One

Immune Properties of Human Umbilical Cord Wharton's Jelly-Derived Cells

(2008) Mark L. Weiss et al.   STEM CELLS

IFATS Collection: The Conditioned Media of Adipose Stromal Cells Protect Against Hypoxia-Ischemia-Induced Brain Damage in Neonatal Rats

(2008) Xing Wei et al.   STEM CELLS

Functional Recovery of Chronic Paraplegic Pigs After Autologous Transplantation of Bone Marrow Stromal Cells

(2008) Mercedes Zurita et al.   TRANSPLANTATION

Concise Review: Wharton's Jelly-Derived Cells Are a Primitive Stromal Cell Population

(2007) Deryl L. Troyer et al.   STEM CELLS