Journal
PROGRESS IN NEUROBIOLOGY
Volume 92, Issue 3, Pages 245-276Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2010.10.002
Keywords
Axon regeneration; Peripheral nerve injury; Nerve grafting; Autologous nerves; Neurodegeneration; Neuropathic pain; Nerve guides; Nerve repair
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Funding
- Royal Dutch Academy of Arts and Sciences
- Dutch Polymer Institute (DPI) [608]
- German Aerospace Center [01GN0109]
- EC [LSHB-CT-2005-518233]
- German Ministry for Research [DFG BR 2299/4-1]
- Interdisciplinary Centre for Clinical Research IZKF within the Faculty of Medicine at the RWTH Aachen University [TVB 111]
- German Federal Ministry of Education and Research (BMBF) [0315140, 0313640]
- Stiftung Sibylle Assmus
- Nervclub
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Peripheral nerve injuries that induce gaps larger than 1-2 cm require bridging strategies for repair. Autologous nerve grafts are still the gold standard for such interventions, although alternative treatments, as well as treatments to improve the therapeutic efficacy of autologous nerve grafting are generating increasing interest. Investigations are still mostly experimental, although some clinical studies have been undertaken. In this review, we aim to describe the developments in bridging technology which aim to replace the autograft. A multi-disciplinary approach is of utmost importance to develop and optimise treatments of the most challenging peripheral nerve injuries. (C) 2010 Elsevier Ltd. All rights reserved.
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