The three Rs along the TRAIL: Resistance, re-sensitization and reactive oxygen species (ROS)

Proteasome Inhibitors Enhance TRAIL-Induced Apoptosis through the Intronic Regulation of DR5: Involvement of NF- B and Reactive Oxygen Species-Mediated p53 Activation

(2014) J.-J. Chen et al.   JOURNAL OF IMMUNOLOGY

Death Receptors 4 and 5 Activate Nox1 NADPH Oxidase through Riboflavin Kinase to Induce Reactive Oxygen Species-mediated Apoptotic Cell Death

(2011) Kyung-Jin Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ROS and CHOP Are Critical for Dibenzylideneacetone to Sensitize Tumor Cells to TRAIL through Induction of Death Receptors and Downregulation of Cell Survival Proteins

(2010) Sahdeo Prasad et al.   CANCER RESEARCH

Human catalase: looking for complete identity

(2010) Madhur M. Goyal et al.   Protein & Cell

Targeting and Regulation of Reactive Oxygen Species Generation by Nox Family NADPH Oxidases

(2009) Thomas L. Leto et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive oxygen species and peroxisomes: Struggling for balance

(2009) Nina A. Bonekamp et al.   BIOFACTORS

Small Molecule XIAP Inhibitors Enhance TRAIL-Induced Apoptosis and Antitumor Activity in Preclinical Models of Pancreatic Carcinoma

(2009) M. Vogler et al.   CANCER RESEARCH

LY303511 Enhances TRAIL Sensitivity of SHEP-1 Neuroblastoma Cells via Hydrogen Peroxide-Mediated Mitogen-Activated Protein Kinase Activation and Up-regulation of Death Receptors

(2009) K. Shenoy et al.   CANCER RESEARCH

Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP

(2009) Tae-Jin Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation

(2009) Catherine Gill et al.   Molecular Cancer

Daidzein overcomes TRAIL-resistance in malignant glioma cells by modulating the expression of the intrinsic apoptotic inhibitor, bcl-2

(2009) M.D. Siegelin et al.   NEUROSCIENCE LETTERS

Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling

(2008) Aurélie Rossin et al.   BIOCHEMICAL JOURNAL

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance

(2008) M. Fakler et al.   BLOOD

Stable XIAP knockdown clones of HCT116 colon cancer cells are more sensitive to TRAIL, taxanes and irradiation in vitro

(2008) Kate Connolly et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

BH3 Mimetic ABT-737 Potentiates TRAIL-Mediated Apoptotic Signaling by Unsequestering Bim and Bak in Human Pancreatic Cancer Cells

(2008) S. Huang et al.   CANCER RESEARCH

Proteasome inhibitor PS-341 (VELCADE) induces stabilization of the TRAIL receptor DR5 mRNA through the 3'-untranslated region

(2008) K. Kandasamy et al.   MOLECULAR CANCER THERAPEUTICS

The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin

(2008) M. D. Siegelin et al.   MOLECULAR CANCER THERAPEUTICS

Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells

(2008) X. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Quercetin promotes degradation of survivin and thereby enhances death-receptor–mediated apoptosis in glioma cells

(2008) Markus D. Siegelin et al.   NEURO-ONCOLOGY

Rosiglitazone promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP

(2007) Yeoun Hee Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE