The Activation of the Sox2 RR2 Pluripotency Transcriptional Reporter in Human Breast Cancer Cell Lines is Dynamic and Labels Cells with Higher Tumorigenic Potential

Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma

(2014) Robert J. Vanner et al.   CANCER CELL

Sox2: Masterminding the Root of Cancer

(2014) Wai Leong Tam et al.   CANCER CELL

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma

(2014) Soufiane Boumahdi et al.   NATURE

ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program

(2013) E. Charafe-Jauffret et al.   CANCER RESEARCH

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Reprogramming of non-genomic estrogen signaling by the stemness factor SOX2 enhances the tumor-initiating capacity of breast cancer cells

(2013) Alejandro Vazquez-Martin et al.   CELL CYCLE

Targeting IL-8 signalling to inhibit breast cancer stem cell activity

(2013) Jagdeep K Singh et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 mice

(2013) J L Little et al.   ONCOGENE

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

(2012) Wenjun Guo et al.   CELL

Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells

(2012) Alejandro Vazquez-Martin et al.   CELL CYCLE

Cancer Stem Cells: Current Status and Evolving Complexities

(2012) Jane E. Visvader et al.   Cell Stem Cell

Identification of two novel phenotypically distinct breast cancer cell subsets based on Sox2 transcription activity

(2012) Fang Wu et al.   CELLULAR SIGNALLING

The developing cancer stem-cell model: clinical challenges and opportunities

(2012) Louis Vermeulen et al.   LANCET ONCOLOGY

Human Breast Cancer Cells Are Redirected to Mammary Epithelial Cells upon Interaction with the Regenerating Mammary Gland Microenvironment In-Vivo

(2012) Karen M. Bussard et al.   PLoS One

Induced Pluripotency and Oncogenic Transformation Are Related Processes

(2012) John W. Riggs et al.   STEM CELLS AND DEVELOPMENT

Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma

(2011) Claudia Lengerke et al.   BMC CANCER

Pluripotency Factors in Embryonic Stem Cells Regulate Differentiation into Germ Layers

(2011) Matt Thomson et al.   CELL

Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells

(2011) Annalisa Pezzolo et al.   CELL RESEARCH

Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype

(2011) S. Ricardo et al.   JOURNAL OF CLINICAL PATHOLOGY

Sox2 expression in breast tumours and activation in breast cancer stem cells

(2011) O Leis et al.   ONCOGENE

NEDD9 Is a Positive Regulator of Epithelial-Mesenchymal Transition and Promotes Invasion in Aggressive Breast Cancer

(2011) Chenfei Kong et al.   PLoS One

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

(2011) D. Iliopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

(2010) Marie Zbinden et al.   EMBO JOURNAL

ATF3, an adaptive-response gene, enhances TGF  signaling and cancer-initiating cell features in breast cancer cells

(2010) X. Yin et al.   JOURNAL OF CELL SCIENCE

Increased NOS2 predicts poor survival in estrogen receptor–negative breast cancer patients

(2010) Sharon A. Glynn et al.   JOURNAL OF CLINICAL INVESTIGATION

p53 connects tumorigenesis and reprogramming to pluripotency: Figure 1.

(2010) Natalia Tapia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Babelomics: an integrative platform for the analysis of transcriptomics, proteomics and genomic data with advanced functional profiling

(2010) Ignacio Medina et al.   NUCLEIC ACIDS RESEARCH

The normal mammary microenvironment suppresses the tumorigenic phenotype of mouse mammary tumor virus-neu-transformed mammary tumor cells

(2010) B W Booth et al.   ONCOGENE

Expression of an Exogenous Human Oct-4 Promoter Identifies Tumor-Initiating Cells in Osteosarcoma

(2009) P. P. Levings et al.   CANCER RESEARCH

NEDD9 Promotes Oncogenic Signaling in Mammary Tumor Development

(2009) E. Izumchenko et al.   CANCER RESEARCH

Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

(2009) Emmanuelle Charafe-Jauffret et al.   CANCER RESEARCH

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

(2009) Teruhisa Kawamura et al.   NATURE

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

(2009) Hyenjong Hong et al.   NATURE

Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency

(2009) Akitsu Hotta et al.   NATURE METHODS

Effects of dependence in high-dimensional multiple testing problems

(2008) Kyung In Kim et al.   BMC BIOINFORMATICS

The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis

(2008) Aijin Wang et al.   BMC CANCER

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Endothelial cell differentiation of human breast tumour stem/progenitor cells

(2008) Benedetta Bussolati et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

High-throughput functional annotation and data mining with the Blast2GO suite

(2008) S. Gotz et al.   NUCLEIC ACIDS RESEARCH

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

(2008) Anne-Pierre Morel et al.   PLoS One

Regulation of Self-Renewal and Pluripotency by Sox2 in Human Embryonic Stem Cells

(2008) Helen Fong et al.   STEM CELLS