Oncolytic Viruses as Anticancer Vaccines

Bortezomib-Induced Unfolded Protein Response Increases Oncolytic HSV-1 Replication Resulting in Synergistic Antitumor Effects

(2014) J. Y. Yoo et al.   CLINICAL CANCER RESEARCH

True Grit: Programmed Necrosis in Antiviral Host Defense, Inflammation, and Immunogenicity

(2014) E. S. Mocarski et al.   JOURNAL OF IMMUNOLOGY

Mitophagy Enhances Oncolytic Measles Virus Replication by Mitigating DDX58/RIG-I-Like Receptor Signaling

(2014) M. Xia et al.   JOURNAL OF VIROLOGY

Maraba MG1 Virus Enhances Natural Killer Cell Function via Conventional Dendritic Cells to Reduce Postoperative Metastatic Disease

(2014) Jiqing Zhang et al.   MOLECULAR THERAPY

Localized Oncolytic Virotherapy Overcomes Systemic Tumor Resistance to Immune Checkpoint Blockade Immunotherapy

(2014) D. Zamarin et al.   Science Translational Medicine

Oncolytic Immunotherapy: Dying the Right Way is a Key to Eliciting Potent Antitumor Immunity

(2014) Zong Sheng Guo et al.   Frontiers in Oncology

Development of ipilimumab: a novel immunotherapeutic approach for the treatment of advanced melanoma

(2013) Jedd D. Wolchok et al.   Annals of the New York Academy of Sciences

Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans

(2013) C. J. Breitbach et al.   CANCER RESEARCH

IL-24 sensitizes tumor cells to TLR3-mediated apoptosis

(2013) R Weiss et al.   CELL DEATH AND DIFFERENTIATION

Perioperative Influenza Vaccination Reduces Postoperative Metastatic Disease by Reversing Surgery-Induced Dysfunction in Natural Killer Cells

(2013) L.-H. Tai et al.   CLINICAL CANCER RESEARCH

Cetuximab-Activated Natural Killer and Dendritic Cells Collaborate to Trigger Tumor Antigen-Specific T-cell Immunity in Head and Neck Cancer Patients

(2013) R. M. Srivastava et al.   CLINICAL CANCER RESEARCH

Crosstalk between ER stress and immunogenic cell death

(2013) Oliver Kepp et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Microsphere priming facilitates induction of potent therapeutic T-cell immune responses against autochthonous liver cancers

(2013) Benjamin Brinkhoff et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Deciphering and Reversing Tumor Immune Suppression

(2013) Greg T. Motz et al.   IMMUNITY

Dendritic-Cell-Based Therapeutic Cancer Vaccines

(2013) Karolina Palucka et al.   IMMUNITY

Treg and CTLA-4: Two intertwining pathways to immune tolerance

(2013) Lucy S.K. Walker   JOURNAL OF AUTOIMMUNITY

Peptidases released by necrotic cells control CD8+ T cell cross-priming

(2013) Jaba Gamrekelashvili et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor Exome Analysis Reveals Neoantigen-Specific T-Cell Reactivity in an Ipilimumab-Responsive Melanoma

(2013) Nienke van Rooij et al.   JOURNAL OF CLINICAL ONCOLOGY

Autophagy Benefits the Replication of Newcastle Disease Virus in Chicken Cells and Tissues

(2013) Y. Sun et al.   JOURNAL OF VIROLOGY

Innate Immune Defense Defines Susceptibility of Sarcoma Cells to Measles Vaccine Virus-Based Oncolysis

(2013) S. Berchtold et al.   JOURNAL OF VIROLOGY

Oncolytic viruses as therapeutic cancer vaccines

(2013) David L Bartlett et al.   Molecular Cancer

Vaccinia Virus Induces Programmed Necrosis in Ovarian Cancer Cells

(2013) Lynsey M Whilding et al.   MOLECULAR THERAPY

Oncolytic Adenovirus With Temozolomide Induces Autophagy and Antitumor Immune Responses in Cancer Patients

(2013) Ilkka Liikanen et al.   MOLECULAR THERAPY

Oncolytic Virotherapy and Immunogenic Cancer Cell Death: Sharpening the Sword for Improved Cancer Treatment Strategies

(2013) Samuel T Workenhe et al.   MOLECULAR THERAPY

Immunogenic HSV-mediated Oncolysis Shapes the Antitumor Immune Response and Contributes to Therapeutic Efficacy

(2013) Samuel T Workenhe et al.   MOLECULAR THERAPY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Akt Regulates TNFα Synthesis Downstream of RIP1 Kinase Activation during Necroptosis

(2013) Colleen R. McNamara et al.   PLoS One

Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model

(2013) T. A. Cheema et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Oncolytic and Immunotherapeutic Vaccinia Induces Antibody-Mediated Complement-Dependent Cancer Cell Lysis in Humans

(2013) M. K. Kim et al.   Science Translational Medicine

The Transcription Factor IRF3 Triggers “Defensive Suicide” Necrosis in Response to Viral and Bacterial Pathogens

(2013) Nelson C. Di Paolo et al.   Cell Reports

Oncolytic vesicular stomatitis virus quantitatively and qualitatively improves primary CD8+T-cell responses to anticancer vaccines

(2013) Byram W Bridle et al.   OncoImmunology

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication

(2012) Chunchun Meng et al.   ARCHIVES OF VIROLOGY

Oncolytic Virus and Anti-4-1BB Combination Therapy Elicits Strong Antitumor Immunity against Established Cancer

(2012) L. B. John et al.   CANCER RESEARCH

Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

(2012) I. Diaconu et al.   CANCER RESEARCH

Preventing Postoperative Metastatic Disease by Inhibiting Surgery-Induced Dysfunction in Natural Killer Cells

(2012) L.-H. Tai et al.   CANCER RESEARCH

Exploiting the Mutanome for Tumor Vaccination

(2012) J. C. Castle et al.   CANCER RESEARCH

Coxsackievirus B3 Is an Oncolytic Virus with Immunostimulatory Properties That Is Active against Lung Adenocarcinoma

(2012) S. Miyamoto et al.   CANCER RESEARCH

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

The cancer antigenome

(2012) Bianca Heemskerk et al.   EMBO JOURNAL

Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer

(2012) Alexander Pedroza-Gonzalez et al.   HEPATOLOGY

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

Enhanced antitumoral activity of oncolytic herpes simplex virus with gemcitabine using colorectal tumor models

(2012) Shinichi Esaki et al.   INTERNATIONAL JOURNAL OF CANCER

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of Immunomodulatory Neutrophil-activating Protein of Helicobacter pylori Enhances the Antitumor Activity of Oncolytic Measles Virus

(2012) Ianko D Iankov et al.   MOLECULAR THERAPY

ORFV: A Novel Oncolytic and Immune Stimulating Parapoxvirus Therapeutic

(2012) Julia L Rintoul et al.   MOLECULAR THERAPY

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

(2012) Hirokazu Matsushita et al.   NATURE

Using virally expressed melanoma cDNA libraries to identify tumor-associated antigens that cure melanoma

(2012) Jose Pulido et al.   NATURE BIOTECHNOLOGY

Oncolytic virotherapy

(2012) Stephen J Russell et al.   NATURE BIOTECHNOLOGY

NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors

(2012) Christopher A Alvarez-Breckenridge et al.   NATURE MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape

(2012) J. M. Taube et al.   Science Translational Medicine

Virus-Tumor Interactome Screen Reveals ER Stress Response Can Reprogram Resistant Cancers for Oncolytic Virus-Triggered Caspase-2 Cell Death

(2011) Douglas J. Mahoney et al.   CANCER CELL

Viral subversion of immunogenic cell death

(2011) Oliver Kepp et al.   CELL CYCLE

Innate immune recognition of poxviral vaccine vectors

(2011) Erin L Lousberg et al.   Expert Review of Vaccines

Targeted cancer immunotherapy with oncolytic adenovirus coding for a fully human monoclonal antibody specific for CTLA-4

(2011) J D Dias et al.   GENE THERAPY

Measles virus causes immunogenic cell death in human melanoma

(2011) O G Donnelly et al.   GENE THERAPY

Strategies to Enhance Viral Penetration of Solid Tumors

(2011) Elspeth Smith et al.   HUMAN GENE THERAPY

Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice

(2011) Norman Woller et al.   JOURNAL OF CLINICAL INVESTIGATION

Attenuated, Oncolytic, but Not Wild-Type Measles Virus Infection Has Pleiotropic Effects on Human Neutrophil Function

(2011) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Oncolytic Virus-initiated Protective Immunity Against Prostate Cancer

(2011) Shashi A Gujar et al.   MOLECULAR THERAPY

Chemokine Expression From Oncolytic Vaccinia Virus Enhances Vaccine Therapies of Cancer

(2011) Jun Li et al.   MOLECULAR THERAPY

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Broad antigenic coverage induced by vaccination with virus-based cDNA libraries cures established tumors

(2011) Timothy Kottke et al.   NATURE MEDICINE

Reovirus therapy stimulates endoplasmic reticular stress, NOXA induction and augments bortezomib-mediated apoptosis in multiple myeloma

(2011) K R Kelly et al.   ONCOGENE

Type III IFN Interleukin-28 Mediates the Antitumor Efficacy of Oncolytic Virus VSV in Immune-Competent Mouse Models of Cancer

(2010) Phonphimon Wongthida et al.   CANCER RESEARCH

Virus Inhibition of RIP3-Dependent Necrosis

(2010) Jason W. Upton et al.   Cell Host & Microbe

OPTIM trial: a Phase III trial of an oncolytic herpes virus encoding GM-CSF for unresectable stage III or IV melanoma

(2010) Howard L Kaufman et al.   Future Oncology

Antitumoural immunity by virus-mediated immunogenic apoptosis inhibits metastatic growth of hepatocellular carcinoma

(2010) B. Boozari et al.   GUT

Reprogrammed Foxp3+ Regulatory T Cells Provide Essential Help to Support Cross-presentation and CD8+ T Cell Priming in Naive Mice

(2010) Madhav D. Sharma et al.   IMMUNITY

Uric acid promotes an acute inflammatory response to sterile cell death in mice

(2010) Hajime Kono et al.   JOURNAL OF CLINICAL INVESTIGATION

Potentiating Cancer Immunotherapy Using an Oncolytic Virus

(2010) Byram W Bridle et al.   MOLECULAR THERAPY

VSV Oncolytic Virotherapy in the B16 Model Depends Upon Intact MyD88 Signaling

(2010) Phonphimon Wongthida et al.   MOLECULAR THERAPY

Adaptive Antiviral Immunity Is a Determinant of the Therapeutic Success of Oncolytic Virotherapy

(2010) Paul T Sobol et al.   MOLECULAR THERAPY

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Host Lymphodepletion Enhances the Therapeutic Activity of an Oncolytic Vaccinia Virus Expressing 4-1BB Ligand

(2009) H. S. Kim et al.   CANCER RESEARCH

Antitumoral Immune Response by Recruitment and Expansion of Dendritic Cells in Tumors Infected with Telomerase-Dependent Oncolytic Viruses

(2009) Edukulla Ramakrishna et al.   CANCER RESEARCH

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Improved Systemic Delivery of Oncolytic Reovirus to Established Tumors Using Preconditioning with Cyclophosphamide-Mediated Treg Modulation and Interleukin-2

(2009) T. Kottke et al.   CLINICAL CANCER RESEARCH

The Case of Oncolytic Viruses Versus the Immune System: Waiting on the Judgment of Solomon

(2009) Robin J. Prestwich et al.   HUMAN GENE THERAPY

Virus Binding to a Plasma Membrane Receptor Triggers Interleukin-1α-Mediated Proinflammatory Macrophage Response In Vivo

(2009) Nelson C. Di Paolo et al.   IMMUNITY

Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal Infection

(2009) Guillaume Oldenhove et al.   IMMUNITY

Tregs control the development of symptomatic West Nile virus infection in humans and mice

(2009) Marion C. Lanteri et al.   JOURNAL OF CLINICAL INVESTIGATION

Vesicular Stomatitis Virus as a Novel Cancer Vaccine Vector to Prime Antitumor Immunity Amenable to Rapid Boosting With Adenovirus

(2009) Byram W Bridle et al.   MOLECULAR THERAPY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection

(2009) Luc English et al.   NATURE IMMUNOLOGY

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Immunogenic death of colon cancer cells treated with oxaliplatin

(2009) A Tesniere et al.   ONCOGENE

Enhanced oncolytic potency of vesicular stomatitis virus through vector-mediated inhibition of NK and NKT cells

(2008) J Altomonte et al.   CANCER GENE THERAPY

Recombinant vesicular stomatitis virus targeted to Her2/neu combined with anti-CTLA4 antibody eliminates implanted mammary tumors

(2008) Y Gao et al.   CANCER GENE THERAPY

Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy

(2008) C. Marcela Diaz-Montero et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Tumor Infection by Oncolytic Reovirus Primes Adaptive Antitumor Immunity

(2008) R. J. Prestwich et al.   CLINICAL CANCER RESEARCH

Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells

(2008) T Yokoyama et al.   GENE THERAPY

Cancer Immunotherapy by Dendritic Cells

(2008) Cornelis J.M. Melief   IMMUNITY

Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial

(2008) Byeong-Ho Park et al.   LANCET ONCOLOGY

Immunosuppression Enhances Oncolytic Adenovirus Replication and Antitumor Efficacy in the Syrian Hamster Model

(2008) Maria A Thomas et al.   MOLECULAR THERAPY

Treg Depletion–enhanced IL-2 Treatment Facilitates Therapy of Established Tumors Using Systemically Delivered Oncolytic Virus

(2008) Timothy Kottke et al.   MOLECULAR THERAPY

Coordination of Early Protective Immunity to Viral Infection by Regulatory T Cells

(2008) J. M. Lund et al.   SCIENCE

Exponential Enhancement of Oncolytic Vesicular Stomatitis Virus Potency by Vector-mediated Suppression of Inflammatory Responses In Vivo

(2007) Jennifer Altomonte et al.   MOLECULAR THERAPY