Article
Microbiology
Zheng Zhang, Congyu Lu, Bocheng Mo, Kehan Bai, Xing-Yi Ge, Li Deng, Yousong Peng
Summary: This study systematically investigated host proteins associated with the cross-species transmission of mammalian viruses and built machine-learning models to predict the transmission potential based on these host factors. The study deepens our understanding of the mechanism of virus cross-species transmission and provides a framework for predicting the cross-species transmission of mammalian viruses based on host factors.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Zheng Zhang, Congyu Lu, Bocheng Mo, Kehan Bai, Xing-Yi Ge, Li Deng, Yousong Peng
Summary: Understanding and predicting the cross-species transmission potential of mammalian viruses is crucial for the prevention and control of emerging viruses. This study systematically investigated the host proteins associated with virus cross-species transmission and built machine-learning models based on these host proteins to predict the transmission potential. The study also evaluated the contribution of virus receptors and found their effect to be minor.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemical Research Methods
Bill Lee, David K. Smith, Yi Guan
Summary: The study used machine learning models to predict the reservoir hosts of viruses, combining sequence alignment and gradient boosting machines to improve prediction accuracy.
Review
Biology
Bader Alshehri
Summary: Exosomal miRNAs play a critical role in cancer evolution, with the ability to transfer across species to affect gene expression. While plant miRNAs may impact human disease-related genes, the hypothesis of cross-kingdom gene regulation remains controversial due to lack of reproducibility in research results.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemical Research Methods
Florian Mock, Adrian Viehweger, Emanuel Barth, Manja Marz
Summary: Zoonosis, the transmission of infections from animals to humans, is a global issue that requires accurate prediction of the viral host to prevent further spread. A new deep learning approach based on viral genome sequence shows high accuracy in predicting the host of viruses, even with limited sequences and unbalanced data.
Review
Cell Biology
Nicole L. Diggins, Meaghan H. Hancock
Summary: Viruses use various mechanisms to overcome barriers to infection in host cells. One such mechanism is the use of virally-encoded microRNAs (miRNAs) to regulate host gene expression for the benefit of the virus. Despite little sequence homology, different viruses target common cellular pathways such as apoptosis, immune evasion, cell growth, and differentiation. This article highlights the importance of viral miRNAs in lytic and latent infections by targeting these common cellular processes and provides insights into their mimicry of host cell miRNAs and regulation of host miRNA expression.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fabian Kern, Lena Krammes, Karin Danz, Caroline Diener, Tim Kehl, Oliver Kuechler, Tobias Fehlmann, Mustafa Kahraman, Stefanie Rheinheimer, Ernesto Aparicio-Puerta, Sylvia Wagner, Nicole Ludwig, Christina Backes, Hans-Peter Lenhof, Hagen von Briesen, Martin Hart, Andreas Keller, Eckart Meese
Summary: MiRNAs are regulators of gene expression, and their target genes are not randomly distributed in the transcriptome, but share functional pathways. The HiTmIR strategy efficiently validates target genes and provides a resource for training or benchmarking other target predictors.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Immunology
Ubaid Ur Rehman, Dawood Ghafoor, Asad Ullah, Riaz Ahmad, Sumaira Hanif
Summary: This review examines the role of epigenetics in regulating virus infection cycles and gene expression, and explores the potential treatment options based on this understanding.
MICROBIAL PATHOGENESIS
(2023)
Review
Nutrition & Dietetics
Abdul Fatah A. Samad, Mohd Farizal Kamaroddin, Muhammad Sajad
Summary: miRNAs are well-known for their regulatory roles in genetic systems of mammals and plants, acting post-transcriptionally to regulate gene expression. Recently, plant-derived miRNAs have been found to have the ability to regulate gene expression in mammals, sparking discussions among researchers. The transfer of plant miRNAs through diet and their ability to survive in the digestive tract, enter the circulatory system, and regulate endogenous mRNAs have opened up new possibilities for research and potential applications in dietary therapy.
ADVANCES IN NUTRITION
(2021)
Review
Immunology
Lin Lei, Anchun Cheng, Mingshu Wang, Renyong Jia
Summary: This article discusses the relationships between miRNAs in host cells and RNA viruses, including the regulation of gene expression by miRNAs and their impact on RNA virus replication.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dave T. Ste-Croix, Richard R. Belanger, Benjamin Mimee
Summary: The soybean cyst nematode (SCN - Heterodera glycines) is a highly damaging pest to cultivated soybean. It can restructure host cells into a complex feeding structure called the syncytium using secreted effector proteins. The regulation of these proteins, including through post-transcriptional regulation with microRNAs (miRNAs), is crucial for proper syncytium formation. This study characterized the miRNome of SCN and identified several miRNA families, including cross-kingdom miRNA candidates.
Article
Biology
Wenjiang Zheng, Ting Wang, Chengxin Liu, Qian Yan, Shaofeng Zhan, Geng Li, Xiaohong Liu, Yong Jiang
Summary: Liver injury is a common complication of dengue virus (DENV) infection and is associated with organ dysfunction and fatality. This study identified miRNAs that play a role in DENV infection and revealed the important role of mmu-miR-484, mmu-miR-1247-5p, and mmu-miR-6538 in regulating inflammation and immune responses. These miRNAs collectively modulate multiple signaling pathways that are closely associated with the pathogenic mechanism and treatment strategy of dengue patients.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Virology
Ida Bagus Andika, Mengyuan Tian, Ruiling Bian, Xinran Cao, Ming Luo, Hideki Kondo, Liying Sun
Summary: Virus cross-infection between plants and fungi may play an important role in the spread and evolution of plant and fungal viruses, and facilitate their interaction.
ANNUAL REVIEW OF VIROLOGY
(2023)
Review
Biology
Rayssa M. M. W. Feitosa, Paula Prieto-Oliveira, Helena Brentani, Ariane Machado-Lima
Summary: MicroRNAs (miRNAs) are non-coding RNAs that directly regulate the translation of mRNAs by binding to them. They play important roles in various physiological processes and are associated with disease development. This study presents a systematic review and classification of computational tools for predicting miRNA targets in animals, providing researchers with guidance for tool selection and highlighting the evolution, features, methods, and performance issues of these prediction tools.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2022)
Review
Medicine, Research & Experimental
Sandro Massao Hirabara, Renata Gorjao, Adriana Cristina Levada-Pires, Laureane Nunes Masi, Elaine Hatanaka, Maria Fernanda Cury-Boaventura, Eliane Borges da Silva, Laiane Cristina dos Santos-Oliveira, Vinicius Leonardo Sousa Diniz, Tamires Afonso Duarte Serdan, Vivian Araujo Barbosa de Oliveira, Diego Ribeiro de Souza, Raquel Bragante Gritte, Talita Souza-Siqueira, Raquel Freitas Zambonatto, Tania Cristina Pithon-Curi, Roberto Barbosa Bazotte, Philip Newsholme, Rui Curi
Summary: Viruses consist of a nucleic acid genome and a protein coat, with enveloped viruses having a lipid bilayer membrane. Virus-infected host cells show increased glutamine utilization and metabolism, which is essential for energy production and synthesis of macromolecules necessary for virus assembly.
