Editorial Material
Multidisciplinary Sciences
Philip Ball
Summary: Some researchers argue that lab-grown structures capable of developing into fetuses should be classified and regulated as embryos.
Article
Clinical Neurology
Andrew Peterson, Justin Clapp, Emily A. Largent, Kristin Harkins, Shana D. Stites, Jason Karlawish
Summary: Paradoxical lucidity in dementia is a clinically significant but understudied phenomenon. A refined definition has been proposed by a research group to facilitate debate and potentially harmonize interpretations of paradoxical lucidity among research groups. The goal is to address the vague conceptual features of the provisional definition and create a more robust foundation for clinical research in this area.
ALZHEIMERS & DEMENTIA
(2022)
Review
Orthopedics
David W. Evans, Nicholas Lucas
Summary: This paper derives a set of eligibility criteria from existing definitions of manipulation to create a new definition. The resulting definitions are considered to be valid, complete, minimally sufficient, and robust. It is hoped that these definitions will be widely adopted in clinical, research, educational, and professional settings.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Gastroenterology & Hepatology
Fergus Shanahan, Tarini S. Ghosh, Paul W. O'Toole
Summary: Defining a healthy microbiome in different populations is crucial, but requires improved profiling technologies and understanding the variations and influences on the microbiome among apparently healthy individuals.
Article
Obstetrics & Gynecology
Robert H. Hester, Gabriel N. Hortobagyi, Bora Lim
Summary: Inflammatory breast cancer is a rare and aggressive malignancy often misdiagnosed initially. Symptoms include erythema, skin changes, edema, and warmth of the affected breast. Treatment involves trimodal therapy with chemotherapy, surgery, and radiation, with an aggressive surgical approach enhancing survival outcomes. Early diagnosis is crucial for a favorable locoregional control rate in patients who complete trimodal therapy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Oncology
Charles Dai, Leif W. Ellisen
Summary: Aberrant estrogen receptor (ER) signaling plays a key role in the development of many breast cancers. The androgen receptor (AR), similar to ER, is frequently expressed in breast cancer and has been considered as a potential therapeutic target. However, the understanding of androgen signaling in breast cancer is incomplete and there are conflicting findings regarding the role of AR. This article summarizes the current understanding of AR biology and recent investigations into AR-directed therapies in breast cancer.
Article
Materials Science, Multidisciplinary
Martina Schmid
Summary: The classification of photovoltaic technologies into generations is intended to provide an overview and identify future trends. Despite new definitions being introduced, they lack quantitative justification. In contrast, this classification strengthens the use of numbers, such as efficiency records and module prices, to draw the current picture, compare it to the initial idea, and reveal novel trends and potential.
ADVANCED OPTICAL MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Lydia W. S. Finley
Summary: The uptake and metabolism of nutrients are crucial for various cellular processes, including bioenergetics, biomass production, and cell fate regulation. Although most studies focus on cancer cells, the principles of metabolism observed in cancer cells are applicable to a wide range of mammalian cells. This review aims to explore how cancer metabolism provides a framework for understanding cell metabolism principles and uncovering metabolic networks that meet specific cellular demands. Understanding cell-specific metabolic preferences and vulnerabilities can lead to the development of new strategies to target cancer cells and improve patient care.
Article
Meteorology & Atmospheric Sciences
Dietrich Spaenkuch, Olaf Hellmuth, Ulrich Goersdorf
Summary: This paper discusses the definition of clouds, highlighting the differences between AMS and WMO definitions, as well as information on cloud observation and detection.
BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY
(2022)
Article
Business
Philipp A. Rauschnabel, Barry J. Babin, M. Claudia Tom Dieck, Nina Krey, Timothy Jung
Summary: The article discusses the holistic approach to augmented reality marketing and proposes the BICK FOUR framework as a tool to organize goals. It also introduces several fundamental differences between augmented reality marketing and traditional digital marketing concepts. Insights from managers further enhance the practices of augmented reality marketing, and ethical and legal considerations are also discussed.
JOURNAL OF BUSINESS RESEARCH
(2022)
Review
Oncology
Faina Nakhlis
Summary: Inflammatory breast cancer (IBC) is a rare and aggressive type of breast cancer. Trimodality therapy is the current standard treatment for IBC, but there is limited data on reducing lymph node surgery and preserving the breast. The safest oncologic approach for breast reconstruction in IBC would be delayed reconstruction.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Carmine Valenza, Dario Trapani, Nicola Fusco, Xiaoping Wang, Massimo Cristofanilli, Naoto T. Ueno, Giuseppe Curigliano
Summary: Inflammatory breast cancer (IBC) is a highly aggressive and deadly form of breast cancer driven by an immunosuppressive tumor microenvironment. This study proposes an immunogram for IBC based on preclinical and clinical studies, identifying six parameters related to immune cells, immune checkpoints, and immune status that may predict response to immune-checkpoint inhibitors (ICIs). The combination of chemotherapy and ICIs in IBC patients shows promise, but the design and development of clinical trials incorporating ICIs present challenges.
CANCER TREATMENT REVIEWS
(2023)
Article
Engineering, Environmental
Fiona E. Newman Thacker, Marc Castellnou Ribau, Harm Bartholomeus, Cathelijne R. R. Stoof
Summary: The concept of fire resilience, particularly in the context of fire resilient landscapes, has gained increasing attention as society seeks to understand and coexist with wildfires. However, the lack of an integrated definition has hindered comprehensive research in this area. Based on a synthesis of literature and input from scientists and practitioners, a common definition for fire resilient landscapes is proposed as "a socio-ecological system that accepts the presence of fire, whilst preventing significant losses through landscape management, community engagement and effective recovery." This definition can guide policy development and practical implementation of fire resilient landscapes, as demonstrated through its application in Mediterranean and temperate Europe.
Article
Oncology
Wintana Balema, Diane Liu, Yu Shen, Randa El-Zein, Bisrat G. Debeb, Megumi Kai, Beth Overmoyer, Kathy D. Miller, Huong T. Le-Petross, Naoto T. Ueno, Wendy A. Woodward
Summary: The classic triad of IBC signs is significantly associated with overall survival and related to smoking, post-menopausal status, and metastatic disease. Patients with the classic triad have a significantly lower overall survival rate compared to those with non-classic signs.
Article
Biochemistry & Molecular Biology
Hanna Ilchmann-Diounou, Marie Buleon, Valerie Bacquie, Vassilia Theodorou, Colette Denis, Sandrine Menard
Summary: This study highlights the complexity of Intestinal Passage (IP) measurement, emphasizing that different methods could yield contradictory results. In the case of diabetic NOD mice, diabetic status was found to increase intestinal length and the concentration of FD4 in plasma, without affecting the IP of FD4. Additionally, the study revealed that diabetic NOD mice show changes in intestinal function without signs of intestinal inflammation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)