Reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of Alzheimer’s disease

Hippocampal Extracellular Matrix Levels and Stochasticity in Synaptic Protein Expression Increase with Age and Are Associated with Age-dependent Cognitive Decline

(2014) Marlene J. Végh et al.   MOLECULAR & CELLULAR PROTEOMICS

Enhanced cognitive flexibility in reversal learning induced by removal of the extracellular matrix in auditory cortex

(2014) M. F. K. Happel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress

(2014) A Suttkus et al.   Cell Death & Disease

Depletion of Perineuronal Nets Enhances Recognition Memory and Long-Term Depression in the Perirhinal Cortex

(2013) C. Romberg et al.   JOURNAL OF NEUROSCIENCE

Modeling Alzheimer’s disease in transgenic rats

(2013) Sonia Do Carmo et al.   Molecular Neurodegeneration

Parvalbumin-expressing basket-cell network plasticity induced by experience regulates adult learning

(2013) Flavio Donato et al.   NATURE

Early Enriched Environment Exposure Protects Spatial Memory and Accelerates Amyloid Plaque Formation in APPSwe/PS1L166P Mice

(2013) Francesca Montarolo et al.   PLoS One

Neurochemical mapping of the human hippocampus reveals perisynaptic matrix around functional synapses in Alzheimer’s disease

(2012) Dávid Lendvai et al.   ACTA NEUROPATHOLOGICA

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

The perineuronal net and the control of CNS plasticity

(2012) Difei Wang et al.   CELL AND TISSUE RESEARCH

Differential cell proliferation in the cortex of the appsweps1de9 alzheimer's disease mouse model

(2012) Willem Kamphuis et al.   GLIA

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Synaptic Plasticity Defect Following Visual Deprivation in Alzheimer's Disease Model Transgenic Mice

(2012) C. M. William et al.   JOURNAL OF NEUROSCIENCE

Perisynaptic Chondroitin Sulfate Proteoglycans Restrict Structural Plasticity in an Integrin-Dependent Manner

(2012) C. Orlando et al.   JOURNAL OF NEUROSCIENCE

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A detailed analysis of the early context extinction deficits seen in APPswe/PS1dE9 female mice and their relevance to preclinical Alzheimer's disease

(2011) Charlotte Bonardi et al.   BEHAVIOURAL BRAIN RESEARCH

Extracellular matrix and perineuronal nets in CNS repair

(2011) Jessica C.F. Kwok et al.   Developmental Neurobiology

Training and anti-CSPG combination therapy for spinal cord injury

(2011) Guillermo García-Alías et al.   EXPERIMENTAL NEUROLOGY

Retrieval-specific endocytosis of GluA2-AMPARs underlies adaptive reconsolidation of contextual fear

(2011) Priyanka Rao-Ruiz et al.   NATURE NEUROSCIENCE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Hippocampal synaptic plasticity in Alzheimer’s disease: what have we learned so far from transgenic models?

(2011) Cristina Marchetti et al.   REVIEWS IN THE NEUROSCIENCES

Changes in molecular composition of rat medial prefrontal cortex synapses during adolescent development

(2010) Danielle S. Counotte et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Distribution and classification of aggrecan-based extracellular matrix in the thalamus of the rat

(2010) Georgina Gáti et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

(2010) Moustapha Cissé et al.   NATURE

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

The clinical use of structural MRI in Alzheimer disease

(2010) Giovanni B. Frisoni et al.   Nature Reviews Neurology

Chronic treatment with the α2-adrenoceptor antagonist fluparoxan prevents age-related deficits in spatial working memory in APP×PS1 transgenic mice without altering β-amyloid plaque load or astrocytosis

(2010) G.A. Scullion et al.   NEUROPHARMACOLOGY

Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease

(2010) M. Morawski et al.   NEUROSCIENCE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quantitative cortical synapse proteomics of a transgenic migraine mouse model with mutated CaV2.1 calcium channels

(2010) Oleg I. Klychnikov et al.   PROTEOMICS

Compartmentalization from the outside: the extracellular matrix and functional microdomains in the brain

(2010) Alexander Dityatev et al.   TRENDS IN NEUROSCIENCES

Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls

(2009) Jonathan H. Morra et al.   HUMAN BRAIN MAPPING

Matrix Metalloproteinase-9 Controls NMDA Receptor Surface Diffusion through Integrin  1 Signaling

(2009) P. Michaluk et al.   JOURNAL OF NEUROSCIENCE

Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity

(2009) Renato Frischknecht et al.   NATURE NEUROSCIENCE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

Perineuronal Nets Protect Fear Memories from Erasure

(2009) N. Gogolla et al.   SCIENCE

Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking

(2008) Michel C Van den Oever et al.   NATURE NEUROSCIENCE

Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1ΔE9-deleted transgenic mice model of β-amyloidosis

(2008) Arturas Volianskis et al.   NEUROBIOLOGY OF AGING

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH