Review
Plant Sciences
Xuan Zhou, Qingyu Ma, Zhenqian Yan, Yaxin Wang, Jiajia Qin, Tiejun Tong, Ruixi Liang, Yongxin Li, Yaping Wang, Jiaxu Chen
Summary: This study assessed the effect of Xiao Yao San (XYS) for the treatment of polycystic ovary syndrome (PCOS) through a systematic review and meta-analysis. The results showed that XYS combined with conventional medicines significantly improved ovulation and pregnancy rates, as well as decreased fasting insulin and insulin resistance levels. However, caution is required in interpreting these results due to significant heterogeneity and methodological shortcomings.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Plant Sciences
Ya-Ting Wang, Xiao-Le Wang, Zhen-Zhen Wang, Lan Lei, Die Hu, Yi Zhang
Summary: This review summarizes the antidepressant mechanisms of Xiao-Yao-San (XYS) and its active ingredients, which are reportedly correlated with monoamine neurotransmitter regulation, synaptic plasticity, and hypothalamic-pituitary-adrenal axis. XYS plays a critical role in the treatment of depression by regulating several factors and pathways. However, more clinical and animal studies are needed to further investigate the antidepressant function of XYS and provide more evidence and recommendations for its clinical application.
Article
Chemistry, Multidisciplinary
Chenxiao Shan, Jia Li, Po Sun, Runze Zhou, Min Xu, Qiulong Zhao, Ping Ren, Hongmei Wen, Xi Huang
Summary: A sensitive, precise, and rapid method was developed in this study for the identification of absorbed compounds in the plasma of depressed rats and for the pharmacokinetic analysis. The study provides key information on the chemical and pharmacokinetic profiles of XYSJW, which is important for its therapeutic efficacy and further pharmacological studies.
Article
Plant Sciences
Shuai Ji, Shuangshuang Han, Lin Yu, Lijing Du, Yanting You, Jieyu Chen, Ming Wang, Shengwei Wu, Shasha Li, Xiaomin Sun, Ren Luo, Xiaoshan Zhao
Summary: The study suggests that L. animalis is associated with depression-like behaviors in mice, and JWXYS increases the relative abundance of I. valens related to cerebral purine metabolism, which is positively correlated with the activation of astrocytes in the amygdala.
Review
Medicine, General & Internal
Jing Hu, Jing Teng, Wanyu Wang, Ni Yang, Haoyu Tian, Wei Zhang, Xiangyu Peng, Jingyu Zhang
Summary: The study demonstrated that Xiao Yao San, when used as an auxiliary drug with Western medicine, could improve the efficacy of treating insomnia with anxiety, while also reducing anxiety symptoms. Additionally, the separate use of Xiao Yao San showed benefits in improving sleep quality and relieving anxiety.
Review
Pharmacology & Pharmacy
Yifan Wang, Xiaofeng Chen, Wei Wei, Yiyun Ding, Rongjuan Guo, Jia Xing, Jialin Wang
Summary: This systematic review and meta-analysis found that using the Chinese herbal medicine Xiao Yao San (XYS) combined with anxiolytics is safe and effective for treating anxiety disorders. XYS alone also demonstrated efficacy in the treatment of anxiety disorder, but further large-scale research is needed to investigate adverse events.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Qian Liu, Zongming Shi, Tao Zhang, Tianyuan Jiang, Xiaoying Luo, Xiaolan Su, Yang Yang, Wei Wei
Summary: The meta-analysis showed that Xiao-Yao-San could improve the effective rate of functional gastrointestinal disorders, reduce symptom scores, anxiety and depression scores, and lower recurrence rates. Xiao-Yao-San was found to be safe in most cases, without any serious adverse events.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lingna Xue, Cui Li, Guangbo Ge, Shaoyan Zhang, Liming Tian, Yu Wang, Huiyong Zhang, Zifeng Ma, Zhenhui Lu
Summary: This study revealed that Jia-Wei-Yu-Ping-Feng-San (JWYPFS) can alleviate airway resistance, reduce inflammatory cell concentration, inhibit mucus production, and suppress the expression of type 2 cytokines in asthmatic mice. Additionally, this traditional Chinese medicine significantly decreases the numbers and proportions of ILC2s, as well as the mRNA levels of GATA3 and IRF4.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Ya-Nan Yang, Yu-Ting Deng, Chen-Chen Zang, Fang Zhang, Zi-Bao Huang, Lin Dong, Wei-Ying Lu, Xiao-Po Zhang, Chong-Ming Wu
Summary: The property theory is a unique principle in traditional Chinese medicine that guides doctors to prescribe appropriate medicines based on diseases. The five-flavor theory categorizes various Chinese materia medicas (CMMs) into five flavors based on taste and medical functions. This study found that the functional sets of gut microbiota (CAGs) could serve as a possible indicator to reflect CMM flavor, rather than the composition of microbial community.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Zijun Bai, Weiwei Tao, Yiqun Zhou, Yi Cao, Shun Yu, Zheng Shi
Summary: Xiao-Yao-San reduces anti-tuberculosis drug-induced liver injury symptoms by regulating Grsf1 in the mitochondrial oxidative stress pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Shuangling Yang, Hongzhi Yang, Yaxing Zhang
Summary: Type 2 diabetes mellitus, nonalcoholic fatty liver disease, cardio-cerebrovascular diseases, hyperuricemia and gout, and metabolic-related sexual dysfunction are metabolic diseases that affect human health. The findings from cell or animal models in previous research are challenging to apply clinically due to various differences. Traditional Chinese medicine has been used for over 2,200 years to maintain or improve cardiometabolic health, and our group has collected and studied the classic dietary treatments from ancient literature for metabolic diseases. The exact composition and active ingredients of these treatments are not standardized, and further research is needed.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Woobin Jung, Hyojoo Choi, Jimin Kim, Jeongwoo Kim, Woojin Kim, Fahrul Nurkolis, Bonglee Kim
Summary: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting 6-10% of women worldwide. There is no known cure for PCOS, but medications made from plant extracts have shown potential in alleviating symptoms. This review focuses on the possibility of using plant extracts to treat PCOS by regulating inflammation, hormones, reactive oxygen species (ROS), or autophagy.
Article
Pharmacology & Pharmacy
Liling Yang, Lijun Yan, Weifu Tan, Xiangjun Zhou, Guangli Yang, Jingtao Yu, Zibin Lu, Yong Liu, Liyi Zou, Wei Li, Linzhong Yu
Summary: Sepsis is a life-threatening health disorder with high morbidity and mortality rates, and effective drug treatment is still lacking. Liang-Ge-San (LGS) has anti-inflammatory effects and potential as a treatment for sepsis, but its mechanism of action is unclear.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Xiaopo Zhang, Yanan Yang, Fang Zhang, Jiaqi Yu, Wanying Sun, Ruiqi Wang, Chongming Wu
Summary: The nature of traditional Chinese medicines (TCMs) significantly influences the gut microbiota, with cold-natured TCMs having a stronger impact on microbial functional repertoires. Cold TCMs may exert part of their antidiarrheal effects by modulating the gut microbiota, while hot TCMs may alleviate dysentery through other mechanisms.
Article
Chemistry, Medicinal
Yi Zhang, Xiao-Jun Li, Xin-Rong Wang, Xiao Wang, Guo-Hui Li, Qian-Yin Xue, Ming-Jia Zhang, Hai-Qing Ao
Summary: This study demonstrates that Xiao-Yao-San (XYS) can improve depressive behavior and attenuate inflammation associated with depression. Metabolomic and network pharmacology analyses indicate that XYS alleviates the inflammatory response in depression by modulating multiple metabolic pathways and targets.
Article
Chemistry, Applied
Chia-Lin Lee, Chien-Ming Wang, Hung-Rong Yen, Ying-Chyi Song, Chao-Jung Chen
Summary: A new indazole alkaloid, indigodole E (1), was isolated from Qing Dai, a traditional Chinese medicine. Its chemical structure was determined using various spectroscopic techniques. The compound was found to significantly inhibit the production and gene expression of IL-17A without causing cytotoxicity towards specific cells. These findings suggest that indigodole E (1) may contribute to the anti-IL-17A activity of Qing Dai.
NATURAL PRODUCT RESEARCH
(2022)
Letter
Rheumatology
Wen-Bin Yeh, Wei-Kai Lee, Mei-Chia Chou, Su-Boon Yong, Chia-Jung Li
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Medicine, Research & Experimental
Chuan-Teng Liu, Jui-Hung Jimmy Yen, Dennis A. Brown, Ying-Chyi Song, Mei-Yun Chu, Yu-Hsiang Hung, Yi-Huan Tang, Po-Yuan Wu, Hung-Rong Yen Abckl
Summary: Targeting Nrf2 with D3T may alleviate psoriasis symptoms by reducing hyperkeratosis and scaling, inhibiting IL-17A-secreting γδ T cells in IMQ-induced psoriatic mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Ming-Cheng Huang, Sheng-Chi Chang, Wen-Ling Liao, Tao-Wei Ke, Ai-Lin Lee, Hwei-Ming Wang, Che-Pin Chang, Hung-Rong Yen, Hen-Hong Chang, William Tzu-Liang Chen
Summary: This article reports on the efficacy of acupuncture in preventing chemotherapy-induced peripheral neuropathy in patients with colorectal cancer. The results suggest that acupuncture may have a neuroprotective effect on chemotherapy-induced peripheral neuropathy in patients with colorectal cancer.
Article
Nutrition & Dietetics
Pei-Hsuan Lin, Wan-Ping Su, Chia-Jung Li, Li-Te Lin, Jim Jinn-Chyuan Sheu, Zhi-Hong Wen, Jiin-Tsuey Cheng, Kuan-Hao Tsui
Summary: As women age, the quality of their oocytes deteriorates, leading to reduced fertility. Our comprehensive study involving spatial transcriptomics, single-cell RNA sequencing, human ovarian pathology, and clinical biopsy revealed the complex interactions between ferroptosis and cellular energy metabolism in aging germ cells, uncovering the underlying mechanisms. By supplementing with DHEA, Ubiquinol CoQ10, and Cleo-20 T3 for two months, we observed significant changes in hub genes, confirming our predictions based on multi-omic analysis. Our findings suggest that supplementation interventions improve in vitro fertilization outcomes in aging cells by enhancing metal ion and energy metabolism, thus enhancing oocyte quality in older women.
Review
Pharmacology & Pharmacy
Yen-Dun Tony Tzeng, Jui-Hu Hsiao, Ling-Ming Tseng, Ming-Feng Hou, Chia-Jung Li
Summary: Breast cancer is a common and heterogeneous malignancy in women worldwide. Traditional research methods have limitations, but three-dimensional organoid culture techniques have emerged as a promising alternative. These organoid models can replicate the tumor microenvironments and retain the diversity of breast cancer, making them helpful in studying different stages of the disease. Optimized breast cancer organoid models under precise culture conditions offer numerous advantages, including faithful replication of in vivo traits of breast cancer cells, which have great potential in precision medicine, organ transplantation, disease modeling, gene therapy, and drug innovation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Wan-Ping Su, Chia -Jung Li, Li-Te Lin, Pei-Hsuan Lin, Zhi-Hong Wen, Jim Jinn-Chyuan Sheu, Kuan-Hao Tsui
Summary: The decline in oocyte quality with age is an irreversible process that affects fertility. Aging results in increased abnormality in oocytes, leading to decreased embryo quality, higher miscarriage rates, and birth defects. In addition to oocytes, aging also affects oocyte granulosa cells, particularly in mitochondrial activity. Supplementation with Y-27632 and Vitamin C has shown to improve the quality of aging cells by reducing reactive oxygen species production, restoring mitochondrial membrane potential, and regulating energy metabolism. This supplementation treatment has potential in improving oocyte quality in in vitro fertilization by enhancing mitochondrial metabolism in aging females.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Pei-Yun Shih, Chia-Jung Li, Su-Boon Yong
Summary: Atopic dermatitis is a chronic inflammatory skin disease characterized by immune function imbalance and impaired epidermal barrier function. The JAK/STAT signaling pathway plays a critical role in its pathogenesis, and JAK inhibitors offer a novel therapeutic approach.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Editorial Material
Rheumatology
Jui-Hu Hsiao, Yi-Yu Chou, Chia-Jung Li, Yen-Dun Tony Tzeng
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Editorial Material
Rheumatology
Mei-Chia Chou, Wei-Kai Lee, Wen-Bin Yeh, Su-Boon Yong, Chia-Jung Li, Renin Chang
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Editorial Material
Rheumatology
Mei-Chia Chou, Wei-Kai Lee, Po-Hung Chen, Li-Fei Pan, Su-Boon Yong, Chia-Jung Li
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Integrative & Complementary Medicine
Chia-Yu Huang, Mei-Yao Wu, Ming-Cheng Huang, Teng-Shun Yu, Hung-Rong Yen
Summary: This study investigated the association between acupuncture therapy and the development of pressure ulcers in patients with dementia. The results showed a reduced incidence of pressure ulcers in patients who received acupuncture therapy. This finding provides important insights for further research.
INTEGRATIVE MEDICINE RESEARCH
(2023)
Article
Medicine, General & Internal
Hou-Hsun Liao, Hanoch Livneh, Miao-Chiu Lin, Ming-Chi Lu, Ning-Sheng Lai, Hung-Rong Yen, Tzung-Yi Tsai
Summary: This study aimed to compare the risk of primary Sjogren's Syndrome (SS) in patients with rheumatoid arthritis (RA) who used Chinese herbal medicine (CHM) versus those who did not. The results showed that CHM use was associated with a lower risk of SS.
MEDICINA-LITHUANIA
(2023)
Letter
Rheumatology
Chien-Wei Huang, Wen-Bin Yeh, Ai-Ning Shao, Chia-Jung Li, Li-Fei Pan
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Oncology
Ming-Cheng Huang, Sheng-Chi Chang, Wen-Ling Liao, Tao-Wei Ke, Ai-Lin Lee, Hwei-Ming Wang, Che-Pin Chang, Hung-Rong Yen, Hen-Hong Chang, William Tzu-Liang Chen
Summary: This study investigated the efficacy of acupuncture in preventing chemotherapy-induced peripheral neuropathy (CIPN) in patients with colorectal cancer (CRC). The results showed that prophylactic acupuncture may exert neuroprotective effects on mechanical or tactile touch thresholds and this protectiveness persists at 6 months' follow-up.