Review
Biochemistry & Molecular Biology
Jiayi Zhao, Yiwei Shi, Guangwen Cao
Summary: The initiation and progression of tumors are complex, with the inflammation tumor microenvironment playing a crucial role. Single-cell RNA sequencing (scRNA-seq) can detect the transcription levels of cells, revealing the heterogeneity and evolutionary trajectory of infiltrated immune cells and cancer cells, providing insights into the composition and function of cells in the inflammatory tumor microenvironment.
Article
Oncology
Nicola Tumino, Carina B. Nava Lauson, Silvia Tiberti, Francesca Besi, Stefania Martini, Piera Filomena Fiore, Francesca Scodamaglia, Maria Cristina Mingari, Lorenzo Moretta, Teresa Manzo, Paola Vacca
Summary: This study highlights the importance of metabolic interactions between NK cells and the tumor microenvironment and proposes metabolic dysfunction as a major mechanism behind NK cell failure in cancer treatment. The results show that IL15 plays an unprecedented role in the metabolic reprogramming of NK cells, enhancing their antitumor functions.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Immunology
MingHua Cui, YueHui Liu, Li Cheng, Tao Li, YongZhi Deng, Da Liu
Summary: Ovarian cancer is a highly deadly malignancy among women, and its complex pathogenesis remains largely unknown. The tumor microenvironment plays a crucial role in tumor progression and treatment. MicroRNAs have been shown to regulate ovarian cancer development by affecting the tumor microenvironment. Therefore, identifying new tumor biomarkers and therapeutic targets is of great significance for ovarian cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Antonino B. D'Assoro, Roberto Leon-Ferre, Eike-Benjamin Braune, Urban Lendahl
Summary: The Notch signaling pathway is important for normal development, but dysregulation of this pathway is associated with various types of tumors. In addition to its role in tumor cells, Notch signaling also affects non-mutated cells in the tumor microenvironment and their interactions with tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Yanzhu Chen, Zhishang Meng, Lin Zhang, Feng Liu
Summary: This study identifies CD2 as a potential biomarker in the tumor microenvironment of breast cancer, with high expression associated with longer survival and significant correlation with immune-related pathways. It may serve as a complementary approach to improve clinical outcome prediction for breast cancer patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Jianan Xu, Yuanyuan Sun, Weineng Fu, Shuang Fu
Summary: Myc target 1 (MYCT1), located at 6q25.2, is a crucial player in cancer development with widely distributed expression in cells and variable subcellular localization across different cancer types. It is regulated by multiple transcription factors and aberrant expression of MYCT1 impacts key biological processes and tumor immune responses in cancer cells. Despite some debated functions, MYCT1 holds undeniable significance in cancer development. This review aims to comprehensively examine the relationship between MYCT1 and cancer, providing valuable insights for cancer diagnosis and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemical Research Methods
Zicheng Zhang, Siqi Bao, Congcong Yan, Ping Hou, Meng Zhou, Jie Sun
Summary: This study provides an overview of the interaction between tumor-infiltrating immune cells and the tumor microenvironment, data sources, computational methods and software tools for inferring the composition of immune cells in the TME, and discusses future challenges and perspectives for more accurate quantitative analysis of immune cell infiltration in the future.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Oncology
Camilla Volponi, Aurora Gazzillo, Eduardo Bonavita
Summary: In this review, the contribution of immune cell populations in hepatocellular carcinoma (HCC) progression and response to therapy is analyzed. The inflammatory processes associated with liver cancer development are also described. Additionally, the most recent therapeutic approaches focusing on immunotherapies are discussed, particularly ongoing clinical trials. Understanding the immunological networks in the tumor microenvironment of HCC will enhance knowledge of liver immunity and the mechanisms controlling anti-tumor immune responses.
Review
Cell Biology
Fang-yan Gao, Xin-tong Li, Kun Xu, Run-tian Wang, Xiao-xiang Guan
Summary: The dysregulation of the MYC oncogenic family is commonly observed in various tumors and is associated with poor prognosis. The members of the MYC family are transcription factors responsible for regulating gene expression. Among them, c-MYC is closely related to tumor progression and specifically associated with breast cancer prevalence.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Multidisciplinary Sciences
Benjamin A. H. Smith, Anja Deutzmann, Kristina M. Correa, Corleone S. Delaveris, Renumathy Dhanasekaran, Christopher G. Dove, Delaney K. Sullivan, Simon Wisnovsky, Jessica C. Stark, John V. Pluvinage, Srividya Swaminathan, Nicholas M. Riley, Anand Rajan, Ravindra Majeti, Dean W. Felsher, Carolyn R. Bertozzi
Summary: This study reveals that the MYC oncogene regulates the production of Siglec ligands, enabling cancer cells to evade immune responses. MYC controls the expression of the sialyltransferase St6galnac4, resulting in the generation of a glycan called disialyl-T. Disialyl-T functions as a "don't eat me" signal by engaging with macrophage Siglec-E in mice or the human ortholog Siglec-7, thereby preventing cancer cell clearance.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Genetics & Heredity
Zixuan Xiao, Wei Zhang, Guanzhang Li, Wendong Li, Lin Li, Ting Sun, Yufei He, Guang Liu, Lu Wang, Xiaohan Han, Hao Wen, Yong Liu, Yifan Chen, Haoyu Wang, Jing Li, Yubo Fan, Jing Zhang
Summary: This study provides an overview of non-malignant cells in the complex microenvironment of glioblastoma and analyzes their prognostic effects. The results show that astrocytes, macrophages, and other cell types are risk factors, while CD8 T cells and other specific cells play a protective role. The immune system and organogenesis are enriched in negative immune response clusters, while nervous system components are enriched in positive immune response clusters.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Hasan Simsek, Enrico Klotzsch
Summary: The tumor microenvironment has a crucial role in the behavior and development of tumors as well as the immune response against them. Mechanical cues and altered biochemical environment of the tumor niche affect T cell efficacy and tumor progression. Understanding the mechanobiological properties of the tumor microenvironment is crucial for developing new tumor immunotherapies.
Review
Immunology
Pei-Yu Chen, Wen-Fei Wei, Hong-Zhen Wu, Liang-Sheng Fan, Wei Wang
Summary: CAFs are important and heterogeneous components of the tumor extracellular matrix, with different origins and biomarkers, playing a role in immune regulation of the tumor microenvironment and exerting immunosuppressive functions through various mechanisms. Inhibition of CAFs and targeted therapy against CAFs offer new adjuvant means for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Xiaoyu Xue, Rui Li, Zhenni Chen, Guiyu Li, Bisheng Liu, Shanshan Guo, Qianhua Yue, Siye Yang, Linlin Xie, Yiguan Zhang, Junning Zhao, Ruirong Tan
Summary: The relationship between the gut microbiota and cancer immunology is complex and plays a critical role in tumor occurrence, progression, and treatment. The symbiotic microecosystem formed by the gut microbiota, metabolome, and host immunome is fundamental for the analysis of tumor pathogenesis and the development of therapeutic strategies for cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ge Song, Yue Zhang, Jie Tian, Jie Ma, Kai Yin, Huaxi Xu, Shengjun Wang
Summary: Myeloid-derived suppressor cells (MDSCs) are a major component of tumor-induced immunosuppressive environment, and TRAF6 plays a critical role in modulating the immunosuppressive function of MDSCs by mediating K63-linked polyubiquitination and phosphorylation of STAT3. The abnormal accumulation of MDSCs in the peripheral blood of lung cancer patients, with highly expressed TRAF6 and arginase 1, suggests a potential target for antitumor immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)