The tumor microenvironment drives NK cell metabolic dysfunction leading to impaired antitumor activity
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Title
The tumor microenvironment drives NK cell metabolic dysfunction leading to impaired antitumor activity
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF CANCER
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2022-12-05
DOI
10.1002/ijc.34389
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Note: Only part of the references are listed.- Expanded human NK cells from lung cancer patients sensitize patients’ PDL1−negative tumors to PD1-blockade therapy
- (2021) Sophie M Poznanski et al. Journal for ImmunoTherapy of Cancer
- Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment
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- Glucocorticoids and the cytokines IL-12, IL-15 and IL-18 present in the tumor microenvironment induce PD-1 expression on human Natural Killer cells
- (2020) Linda Quatrini et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy
- (2020) Aaron R Lim et al. eLife
- Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells
- (2020) Teresa Manzo et al. JOURNAL OF EXPERIMENTAL MEDICINE
- NK cells and ILCs in tumor immunotherapy
- (2020) Simona Sivori et al. MOLECULAR ASPECTS OF MEDICINE
- Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects
- (2020) Chunxiao Li et al. Molecular Cancer
- Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy
- (2020) Jackie E. Bader et al. MOLECULAR CELL
- Presence of innate lymphoid cells in pleural effusions of primary and metastatic tumors: Functional analysis and expression of PD‐1 receptor
- (2019) Nicola Tumino et al. INTERNATIONAL JOURNAL OF CANCER
- IL-15 enhanced antibody-dependent cellular cytotoxicity mediated by NK cells and macrophages
- (2018) Meili Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers
- (2017) Y Liu et al. ONCOGENE
- IL15 induces a potent antitumor activity in NK cells isolated from malignant pleural effusions and overcomes the inhibitory effect of pleural fluid
- (2017) D. Croxatto et al. OncoImmunology
- Expression of IL-15 in NK cells results in rapid enrichment and selective cytotoxicity of gene-modified effectors that carry a tumor-specific antigen receptor
- (2012) Christiane Sahm et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- NK cells from malignant pleural effusions are not anergic but produce cytokines and display strong antitumor activity on short-term IL-2 activation
- (2012) Paola Vacca et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Sustained effector function of IL-12/15/18–preactivated NK cells against established tumors
- (2012) Jing Ni et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Relapse-Related Molecular Signature in Lung Adenocarcinomas Identifies Patients With Dismal Prognosis
- (2009) Shuta Tomida et al. JOURNAL OF CLINICAL ONCOLOGY
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