Article
Agriculture, Multidisciplinary
Guijie Chen, Dan Chen, Wangting Zhou, Yujia Peng, Chunxu Chen, Wenbiao Shen, Xiaoxiong Zeng, Qingxia Yuan
Summary: The study demonstrates that yeast beta-glucan can improve high-fat diet-induced metabolic syndrome by regulating gut microbiota, reducing pro-inflammatory cytokines, and decreasing relative abundances of bacterial species associated with metabolic changes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Applied
Wai-Yin Cheng, Ka-Lung Lam, Xiaojie Li, Alice Pik-Shan Kong, Peter Chi-Keung Cheung
Summary: This study demonstrated that oral administration of oat beta-glucan can alleviate circadian disruption-induced metabolic syndrome by enhancing gut microbiota diversity, increasing beneficial bacterial populations, and promoting butyrate production to improve weight gain, glucose tolerance, and endocrine function.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Mingyang Xu, Fangmei Ling, Junrong Li, Yidong Chen, Shuang Li, Yiyu Cheng, Liangru Zhu
Summary: This study aimed to explore the role and mechanism of oat beta-glucan in reducing experimental colitis. The findings showed that oat beta-glucan promoted autophagy flux via the EPHB6-TFEB axis, downregulated the expressions of IL-1 beta, IL-6, and TNF-alpha in intestinal epithelial cells, and reduced DSS-induced acute colitis in mice. This effect may be mediated by the main metabolite of oat beta-glucan, butyrate.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Lidija Arapovic, Yi Huang, Elin Manell, Else Verbeek, Linda Keeling, Li Sun, Rikard Landberg, Torbjoern Lundh, Jan Erik Lindberg, Johan Dicksved
Summary: The study evaluated the effects of early supplementation with oat beta-glucan on the gut microbiota composition, short-chain fatty acid concentrations, and gut physiological markers in suckling piglets. The results showed that piglet age had a greater influence on the concentrations of short-chain fatty acids in plasma and the microbiota composition than the supplement. There were significant differences in microbiota composition between litters, and correlations between short-chain fatty acid concentrations and specific microbial taxa were observed. Overall, beta-glucan supplementation did not have a clear impact on the gut environment in suckling piglets, while an age-related pattern emerged.
Article
Agriculture, Dairy & Animal Science
Fernando Gonzalez, Amanda Carelli, Alina Komarcheuski, Mayara Uana, Rodolpho Martin do Prado, Diogo Rossoni, Marcia Gomes, Ricardo Vasconcellos
Summary: This study assessed the effects of adding yeast cell wall compounds (YCWs) to cat food on hindgut fermentation metabolites and fecal microbiota. The results showed that even at low dietary concentrations, YCWs could modulate the metabolism and fecal microbiota traits in cats. This effect was more pronounced in vitro, suggesting that YCWs could potentially contribute to the intestinal health of adult cats fed extruded diets.
Article
Food Science & Technology
Junying Bai, Yan Li, Wenhui Zhang, Mingcong Fan, Haifeng Qian, Hui Zhang, Xiguang Qi, Li Wang
Summary: This study investigated the effect of gut microbial source on oat beta-glucan metabolism by using mice and human fecal microbiota in an in vitro fermentation experiment. The main end products from gut microbial fermentation of beta-glucan were acetate, propionate, and butyrate, with differences in the main product between the mice and human groups. The data suggested that beta-glucan could be completely hydrolyzed by human fecal microbiota but not thoroughly degraded by mice fecal microbiota.
Article
Food Science & Technology
Xuangao Wu, Ting Zhang, Hye Jeong Yang, Yu Yue, Min Jung Kim, Chen Li, Seong In Cheong, Dai Ja Jang, Sunmin Park
Summary: We investigated the effect of oral oat and green onion water extracts (GOO) supplementation on longitudinal bone growth in weaning rats. The compounds found in green onions and oats lowered the binding energy of growth differentiation factor-5 (GDF5) and insulin-like growth factor-1 receptor (IGF1R). The High-GOO group showed similar levels of serum growth hormone (GH) and osteoprotegerin as the Positive-control, as well as similar femur and tibia lengths promoting growth plate zones.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Microbiology
Annefleur M. Koopen, Eduardo L. Almeida, Ilias Attaye, Julia J. Witjes, Elena Rampanelli, Soumia Majait, Marleen Kemper, Johannes H. M. Levels, Alinda W. M. Schimmel, Hilde Herrema, Torsten P. M. Scheithauer, Werner Frei, Lars Dragsted, Bolette Hartmann, Jens J. Holst, Paul W. O'Toole, Albert K. Groen, Max Nieuwdorp
Summary: Recent study investigated the potential synergistic effects of combining a Mediterranean diet with lean donor fecal microbiota transplantation (FMT) in metabolic syndrome subjects. The results showed no significant synergistic effects on insulin sensitivity, although the Mediterranean diet led to reductions in body weight, HOMA-IR, and lipid levels. Further trials are needed to explore the combination of other microbial interventions and diets in metabolic syndrome.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Nutrition & Dietetics
Ruoyu Wang, Zhaofeng Zhang, Sumiya Aihemaitijiang, Chen Ye, Mairepaiti Halimulati, Xiaojie Huang, Haoyuan Qin
Summary: The study demonstrated that oat beta glucan can lower blood glucose levels, improve renal function, significantly decrease serum inflammation levels, enhance intestinal microbial diversity, and modulate the composition of intestinal flora, which in turn delays the progression of diabetic nephropathy.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Martin Gotteland, Alejandra Zazueta, Jose Luis Pino, Andrea Fresard, Veronica Sambra, Juana Codoceo, Maria Jose Cires, Ximena Lopez, Juan Pablo Vivanco, Fabien Magne
Summary: Cereal beta-glucans have positive effects on cholesterolemia, glycaemia, digestive hormones, and gut microbiota. Acute intake of 5 g beta-glucan from oats slows transit time, decreases hunger sensation and postprandial glycaemia, and alters hormone levels without affecting bile-acid synthesis. However, regular daily intake of 3 g beta-glucan does not have an effect on fecal microbiota composition.
Article
Microbiology
Cindy Duysburgh, Pieter Van den Abbeele, Alison Kamil, Lisa Fleige, Peter John De Chavez, YiFang Chu, Wiley Barton, Orla O'Sullivan, Paul D. Cotter, Karina Quilter, Susan A. Joyce, Mike Murphy, Gillian DunnGalvin, Timothy G. Dinan, Massimo Marzorati
Summary: The study investigated the prebiotic activity of a commercial oat product and a novel oat ingredient on individuals with mild hypercholesterolemia through in vitro and in vivo studies. Results showed significant stimulation of beneficial bacteria growth and production of beneficial substances in the gut by both oat products.
Article
Microbiology
Li Ma, Zhengzhong Luo, Yixin Huang, Yan Li, Jing Guan, Tao Zhou, Zhenlong Du, Kang Yong, Xueping Yao, Liuhong Shen, Shumin Yu, Zhijun Zhong, Yanchun Hu, Guangneng Peng, Xiaodong Shi, Suizhong Cao
Summary: This study explored the effects of oat beta-glucan on intestinal function and growth performance of weaned rabbits by using multi-omics integrative analyses. The results showed that oat beta-glucan increased body weight, average daily gain, and average daily food intake, while decreasing markers of systemic inflammation. It also modulated the composition and structure of gut microbiota, increased concentrations of beneficial bacteria, and altered host metabolism. These findings suggest that oat beta-glucan can improve growth performance and protect intestinal function in weaned rabbits.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Danuta Leszczynska, Anna Wirkijowska, Alan Gasinski, Dominika Srednicka-Tober, Joanna Trafialek, Renata Kazimierczak
Summary: Oat is valued for its rich chemical composition and high nutritional value, making it of interest to scientists and nutritionists. Oat products can be considered functional foods with proven preventive and therapeutic effects. However, the development of cereal processing technologies may decrease their functional properties, highlighting the importance of monitoring product quality and technological progress.
APPLIED SCIENCES-BASEL
(2023)
Article
Pharmacology & Pharmacy
Yang Lin, Zi-Yuan Wang, Ma-Jie Wang, Zheng-Meng Jiang, Ya-Qiu Qin, Tian-Qing Huang, Yu Song, Hui-Ting Liang, E-Hu Liu
Summary: This study examined the effects of baicalin (BC) on high-fat diet-induced metabolic syndrome (MetS) in mice and its impact on gut microbiota composition. The results showed that BC could reduce body weight gain, hepatic fat accumulation, and abnormal blood lipids, and increase insulin sensitivity. BC also reversed the alteration of metabolites induced by high-fat diet and affected metabolic pathways. The analysis of gut microbiota demonstrated that BC altered the composition and function of gut microbiota in MetS mice. The study suggests that BC may be a potential therapeutic drug for improving MetS and the gut microbiome could be a novel mechanistic target for BC treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Food Science & Technology
Yueqin Li, Ranran Shi, Chuan Qin, Yunzhen Zhang, Lianliang Liu, Zufang Wu
Summary: The study improved the gluten-free oat dough network structure by using TGase and MP, enhancing the texture and sensory acceptance of the bread. Oat bread had a prebiotic effect by promoting the growth of Bifidobacterium and Lactobacillus/Enterococcus, while inhibiting the growth of Bacteroides.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2021)
