Review
Endocrinology & Metabolism
Wu Jianwei, Tian Ye, Wang Hongwei, Li Dachuan, Zou Fei, Jiang Jianyuan, Wang Hongli
Summary: Bone remodelling is a dynamic process involving bone-resorbing osteoclasts and bone-forming osteoblasts. Excessive osteoclastogenesis can lead to osteolytic diseases, and the receptor activator of NF-kappa B ligand (RANKL) is considered to be an important regulator of osteoclastogenesis. Transforming growth factor beta-activated kinase 1 (TAK1) plays a significant role in RANKL-induced osteoclastogenesis by regulating multiple signaling pathways. Understanding the mechanisms of TAK1 in this process has potential implications for the treatment of osteolytic diseases.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Jean Vacher
Summary: Autosomal recessive osteopetroses (ARO) are rare genetic skeletal disorders with high clinical and molecular heterogeneity. The most severe form is OPTB5 osteopetrosis caused by homozygous mutation in the OSTM1 gene, leading to severe disease in infancy and early death.
Article
Endocrinology & Metabolism
Jing-Yi Xue, Giedre Grigelioniene, Zheng Wang, Gen Nishimura, Aritoshi Iida, Naomichi Matsumoto, Emma Tham, Noriko Miyake, Shiro Ikegawa, Long Guo
Summary: Osteopetrosis is a rare skeletal disorder characterized by increased bone density due to deficient bone resorption. In this study, a patient with autosomal recessive osteopetrosis caused by biallelic pathogenic variants in SLC4A2 was described. The identified variants lead to SLC4A2 dysfunction, emphasizing the importance of SLC4A2 in human osteoclast differentiation.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Yu Ma, Yali Xu, Yanli Zhang, Xiaohong Duan
Summary: Osteopetrosis is a group of genetic bone disorders characterized by increased bone density and defective bone resorption. This review examines the clinical features, types, and related pathogenic genes of osteopetrosis. It also summarizes the characteristics of craniofacial and dental abnormalities in osteopetrosis, discussing the main pathogenic genes and their molecular mechanisms. The craniofacial and dental abnormalities are important for diagnosis of osteopetrosis and other genetic bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Guoju Hong, Lin Zhou, Guanqiang Zheng, Xiaoxia Zheng, Zhenqiu Chen, Wei He, Qiushi Wei
Summary: Liquiritin (LIQ) has the ability to inhibit osteoclast formation and bone-resorbing activity induced by RANKL, and it exerts its effects by reducing ROS levels and suppressing the Ca2+/MAPK-NFATc1 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Gang Wang, Chao Ma, Kai Chen, Ziyi Wang, Heng Qiu, Delong Chen, Jianbo He, Cheng Zhang, Ding Guo, Boyong Lai, Shuangxiao Zhang, Linfeng Huang, Fan Yang, Jinbo Yuan, Leilei Chen, Wei He, Jiake Xu
Summary: This study demonstrates that cycloastragenol (CAG) inhibits the formation and function of osteoclasts by regulating intracellular signaling pathways. It has potential as an alternative treatment for osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Gang Wang, Kai Chen, Chao Ma, Chao Wang, Delong Chen, Jianbo He, Yuhao Liu, Tao Jiang, Jinbo Yuan, Leilei Chen, Wei He, Jiake Xu
Summary: RA is a natural compound that shows potential therapeutic effects by inhibiting osteoclast differentiation and reducing bone loss. It suppresses osteoclastogenesis without causing cell toxicity, making it a promising treatment option for skeletal diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Immunology
Jiachao Guo, Ranyue Ren, Zhou Guo, Kai Sun, Jinpeng He, Jingfan Shao, Xiaolin Wang
Summary: Osteoporosis is a systemic and endocrine bone disorder characterized by decreased bone mineral density, compromised bone strength, and destruction of trabecular structure. The excessive osteoclastogenesis and bone erosion contribute to the progression of the disease. However, existing medications have poor adherence and adverse reactions, highlighting the urgent need for novel therapies for osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Hao Qu, Yuankang Zhang, Rongxin He, Nong Lin, Cong Wang
Summary: Postmenopausal osteoporosis is a chronic systemic metabolic disease caused by excessive bone resorption and reduced bone formation. Anethole, a natural compound, shows potential in inhibiting osteoclast differentiation, reducing bone resorption, and suppressing osteoclast-specific gene expression through blocking ERK and AKT signaling pathways. Our study suggests that anethole may have osteoprotective effects and be a potential treatment for osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chao Liu, Yining Li, Ren Sheng, Xiaowan Han, Li Bao, Chenyin Wang, Weizhi Wang, Xinhai Jiang, Jiangxue Han, Lijuan Lei, Ni Li, Jing Zhang, Minghua Chen, Yan Li, Yexiang Wu, Shunwang Li, Yu Ren, Yanni Xu, Shuyi Si
Summary: The study demonstrated that the N-methylpyridine-chlorofuranformamide analog 3i1 shows promise in upregulating OPG activity, inhibiting RANKL-induced osteoclastogenesis, and promoting osteoblast differentiation, potentially serving as a new therapeutic agent for osteoporosis.
BIOORGANIC CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Jing-yi Xue, Shiro Ikegawa, Long Guo
Summary: SLC4A2 belongs to the SLC4 family of anion exchangers and regulates Cl- and HCO3- exchange, as well as intra- and extra-cellular pH, chloride concentration, and cell volume. It is involved in gastric acid secretion, spermatogenesis, and osteoclastogenesis. Deficiency in SLC4A2 has been found to cause a new type of autosomal recessive osteopetrosis. This review discusses the functions of SLC4A2, particularly in osteoclasts, and contributes to understanding the pathomechanism of SLC4A2-associated osteopetrosis.
Article
Chemistry, Medicinal
Shuan-Jing Wang, Jiahui Zhang, Jing-Zan Zhang, Ruo-Nan Ning, Chen-Chen Li, Xing Xu, Min Jiang, Wen-Wei Qiu
Summary: A series of heterocyclic ring-fused derivatives of 20(S)-protopanaxadiol (PPD) were synthesized and evaluated for their inhibitory effects on RANKL-induced osteoclastogenesis. Compound 33 (SH491) showed the highest potency with 100% inhibition at 0.1 μM and 44.4% inhibition at 0.01 μM, surpassing the lead compound PPD. Cytotoxicity tests indicated that the inhibitory effect was not due to cytotoxicity, and SH491 also affected osteoblastogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
You-Jin Jo, Hye In Lee, Narae Kim, Donghyun Hwang, Jiae Lee, Gong-Rak Lee, Seong-Eun Hong, Hana Lee, Minjeong Kwon, Nam Young Kim, Hyun Jin Kim, Jin Ha Park, Ye Hee Kang, Han Sung Kim, Soo Young Lee, Woojin Jeong
Summary: Studies have shown that Cinchonine inhibits osteoclast differentiation by regulating TAK1 to suppress NFATc1 and PGC1 beta, leading to the suppression of osteoclast differentiation and promotion of osteoblast differentiation. Furthermore, Cinchonine exhibits potential therapeutic effects in mouse models of inflammation-induced bone diseases and postmenopausal osteoporosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yizhen Huang, Yute Yang, Jianle Wang, Shasha Yao, Teng Yao, Yining Xu, Zizheng Chen, Putao Yuan, Jun Gao, Shuying Shen, Jianjun Ma
Summary: The study found that miR-21-5p regulates osteoclast differentiation by targeting SKP2, and treatment with miR-21-5p can inhibit bone resorption in vivo, suggesting that it may be a new therapeutic target for osteoporosis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Honglei Kang, Qian Guo, Yimin Dong, Renpeng Peng, Kehan Song, Jia Wang, Haiyang Liu, Meipeng Zhu, Hongjian Zhao, Hanfeng Guan, Feng Li
Summary: MAT2A is crucial for osteoclastogenesis and may be a potential therapeutic target for the treatment of osteoporosis.
Article
Developmental Biology
Naoki Koda, Tempei Sato, Masahiro Shinohara, Shizuko Ichinose, Yoshiaki Ito, Ryo Nakamichi, Tomohiro Kayama, Kensuke Kataoka, Hidetsugu Suzuki, Keiji Moriyama, Hiroshi Asahara
Article
Veterinary Sciences
Miki Shimbo, Takashi Kudo, Michito Hamada, Hyojung Jeon, Yuki Imamura, Keigo Asano, Risa Okada, Yuki Tsunakawa, Seiya Mizuno, Ken-ichi Yagami, Chihiro Ishikawa, Haiyan Li, Takashi Shiga, Junji Ishida, Juri Hamada, Kazuya Murata, Tomohiro Ishimaru, Misuzu Hashimoto, Akiyoshi Fukamizu, Mutsumi Yamane, Masahito Ikawa, Hironobu Morita, Masahiro Shinohara, Hiroshi Asahara, Taishin Akiyama, Nobuko Akiyama, Hiroki Sasanuma, Nobuaki Yoshida, Rui Zhou, Ying-Ying Wang, Taito Ito, Yuko Kokubu, Taka-aki K. Noguchi, Hisako Ishimine, Akira Kurisaki, Dai Shiba, Hiroyasu Mizuno, Masaki Shirakawa, Naoki Ito, Shin'ichi Takeda, Satoru Takahashi
EXPERIMENTAL ANIMALS
(2016)
Article
Multidisciplinary Sciences
Hidetsugu Suzuki, Yoshiaki Ito, Masahiro Shinohara, Satoshi Yamashita, Shizuko Ichinose, Akio Kishida, Takuya Oyaizu, Tomohiro Kayama, Ryo Nakamichi, Naoki Koda, Kazuyoshi Yagishita, Martin K. Lotz, Atsushi Okawa, Hiroshi Asahara
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Review
Physiology
Kazuo Okamoto, Tomoki Nakashima, Masahiro Shinohara, Takako Negishi-Koga, Noriko Komatsu, Asuka Terashima, Shinichiro Sawa, Takeshi Nitta, Hiroshi Takayanagi
PHYSIOLOGICAL REVIEWS
(2017)
Article
Endocrinology & Metabolism
Masahiro Shinohara, Betty Y. Chang, Joseph J. Buggy, YuSuke Nagai, Tatsuhiko Kodama, Hiroshi Asahara, Hiroshi Takayanagi
Article
Biochemistry & Molecular Biology
Masahiro Shinohara, Takako Koga, Kazuo Okamoto, Shinya Sakaguchi, Kimiko Arai, Hisataka Yasuda, Toshiyuki Takai, Tatsuhiko Kodama, Tomohiro Morio, Raif S. Geha, Daisuke Kitamura, Tomohiro Kurosaki, Wilfried Ellmeier, Hiroshi Takayanagi
Article
Biochemistry & Molecular Biology
Masahiro Shinohara, Yoshifumi Adachi, Junji Mitsushita, Mitsuhiro Kuwabara, Atsushi Nagasawa, Saori Harada, Shuichi Furuta, Yugen Zhang, Kajla Seheli, Hitoshi Miyazaki, Tohru Kamata
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Article
Endocrinology & Metabolism
Masahiro Shinohara, Masaki Nakamura, Hironari Masuda, Jun Hirose, Yuho Kadono, Mitsuyasu Iwasawa, Yuuichi Nagase, Kohjiro Ueki, Takashi Kadowaki, Takehiko Sasaki, Shigeaki Kato, Hiroaki Nakamura, Sakae Tanaka, Hiroshi Takayanagi
JOURNAL OF BONE AND MINERAL RESEARCH
(2012)
Article
Immunology
Karel Otero, Masahiro Shinohara, Haibo Zhao, Marina Cella, Susan Gilfillan, Angela Colucci, Roberta Faccio, F. Patrick Ross, Steve L. Teitelbaum, Hiroshi Takayanagi, Marco Colonna
JOURNAL OF IMMUNOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Takako Negishi-Koga, Masahiro Shinohara, Noriko Komatsu, Haruhiko Bito, Tatsuhiko Kodama, Roland H. Friedel, Hiroshi Takayanagi
Article
Multidisciplinary Sciences
Ryosuke Tateishi, Nobuko Akiyama, Maki Miyauchi, Riko Yoshinaga, Hiroki Sasanuma, Takashi Kudo, Miki Shimbo, Masahiro Shinohara, Koji Obata, Jun-ichiro Inoue, Masaki Shirakawa, Dai Shiba, Hiroshi Asahara, Nobuaki Yoshida, Satoru Takahashi, Hironobu Morita, Taishin Akiyama
Article
Multidisciplinary Sciences
Saori Ohmae, Naruto Noma, Masayasu Toyomoto, Masahiro Shinohara, Masatoshi Takeiri, Hiroaki Fuji, Kenji Takemoto, Keiko Iwaisako, Tomoko Fujita, Norihiko Takeda, Makoto Kawatani, Mineyoshi Aoyama, Masatoshi Hagiwara, Yasushi Ishihama, Masataka Asagiri
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Dai Shiba, Hiroyasu Mizuno, Akane Yumoto, Michihiko Shimomura, Hiroe Kobayashi, Hironobu Morita, Miki Shimbo, Michito Hamada, Takashi Kudo, Masahiro Shinohara, Hiroshi Asahara, Masaki Shirakawa, Satoru Takahashi
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Masahiro Shinohara, Wei-Hao Shang, Makoto Kubodera, Saori Harada, Junji Mitsushita, Masayoshi Kato, Hitoshi Miyazaki, Hideke Sumimoto, Tohru Kamata
JOURNAL OF BIOLOGICAL CHEMISTRY
(2007)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)