Mission (im)possible – mapping the brain becomes a reality

Thin-sheet laser imaging microscopy for optical sectioning of thick tissues

(2018) Peter A. Santi et al.   BIOTECHNIQUES

Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis

(2014) Etsuo A. Susaki et al.   CELL

Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body Clearing

(2014) Bin Yang et al.   CELL

Advanced CLARITY for rapid and high-resolution imaging of intact tissues

(2014) Raju Tomer et al.   Nature Protocols

Specific Disruption of Hippocampal Mossy Fiber Synapses in a Mouse Model of Familial Alzheimer's Disease

(2014) Scott A. Wilke et al.   PLoS One

Imaging ATUM ultrathin section libraries with WaferMapper: a multi-scale approach to EM reconstruction of neural circuits

(2014) Kenneth J. Hayworth et al.   Frontiers in Neural Circuits

ClearT: a detergent- and solvent-free clearing method for neuronal and non-neuronal tissue

(2013) T. Kuwajima et al.   DEVELOPMENT

Is EM dead?

(2013) G. Knott et al.   JOURNAL OF CELL SCIENCE

Brain mapping in high resolution

(2013) Vivien Marx   NATURE

Structural and molecular interrogation of intact biological systems

(2013) Kwanghun Chung et al.   NATURE

Mapping brain circuitry with a light microscope

(2013) Pavel Osten et al.   NATURE METHODS

CLARITY for mapping the nervous system

(2013) Kwanghun Chung et al.   NATURE METHODS

Cardiac Myocyte Diversity and a Fibroblast Network in the Junctional Region of the Zebrafish Heart Revealed by Transmission and Serial Block-Face Scanning Electron Microscopy

(2013) Pascal J. Lafontant et al.   PLoS One

Progressive sheet-to-tubule transformation is a general mechanism for endoplasmic reticulum partitioning in dividing mammalian cells

(2012) Maija Puhka et al.   MOLECULAR BIOLOGY OF THE CELL

Three-dimensional imaging of solvent-cleared organs using 3DISCO

(2012) Ali Ertürk et al.   Nature Protocols

Structural neurobiology: missing link to a mechanistic understanding of neural computation

(2012) Winfried Denk et al.   NATURE REVIEWS NEUROSCIENCE

NeuroD2 regulates the development of hippocampal mossy fiber synapses

(2012) Scott A Wilke et al.   Neural Development

Serial Section Scanning Electron Microscopy (S3EM) on Silicon Wafers for Ultra-Structural Volume Imaging of Cells and Tissues

(2012) Heinz Horstmann et al.   PLoS One

Charting Monosynaptic Connectivity Maps by Two-Color Light-Sheet Fluorescence Microscopy

(2012) Christian J. Niedworok et al.   Cell Reports

Light sheet microscopy of living or cleared specimens

(2011) Philipp J Keller et al.   CURRENT OPINION IN NEUROBIOLOGY

Volume electron microscopy for neuronal circuit reconstruction

(2011) Kevin L Briggman et al.   CURRENT OPINION IN NEUROBIOLOGY

Bulk electroporation and population calcium imaging in the adult mammalian retina

(2011) Kevin L. Briggman et al.   JOURNAL OF NEUROPHYSIOLOGY

Development of High-Throughput, High-Resolution 3D Reconstruction of Large-Volume Biological Tissue Using Automated Tape Collection Ultramicrotomy and Scanning Electron Microscopy

(2011) R Schalek et al.   MICROSCOPY AND MICROANALYSIS

Network anatomy and in vivo physiology of visual cortical neurons

(2011) Davi D. Bock et al.   NATURE

Wiring specificity in the direction-selectivity circuit of the retina

(2011) Kevin L. Briggman et al.   NATURE

Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain

(2011) Hiroshi Hama et al.   NATURE NEUROSCIENCE

High-accuracy neurite reconstruction for high-throughput neuroanatomy

(2011) Moritz Helmstaedter et al.   NATURE NEUROSCIENCE

Three-Dimensional Reconstruction of Brain-wide Wiring Networks in Drosophila at Single-Cell Resolution

(2010) Ann-Shyn Chiang et al.   CURRENT BIOLOGY

Tissue optical immersion clearing

(2010) Elina A Genina et al.   Expert Review of Medical Devices

Going deeper than microscopy: the optical imaging frontier in biology

(2010) Vasilis Ntziachristos   NATURE METHODS

Selective plane illumination microscopy techniques in developmental biology

(2009) J. Huisken et al.   DEVELOPMENT

Multifunctional Pattern-Generating Circuits

(2008) K.L. Briggman et al.   Annual Review of Neuroscience