Article
Chemistry, Physical
Michele Brun, Elisa Sogne, Andrea Falqui, Federico Scaglione, Paola Rizzi, Francesco Delogu, Giorgio Pia
Summary: Nanoporous Au was characterized in three dimensions through serial block face-scanning electron microscopy (SBF-SEM). The corresponding sections were digitized and used to evaluate the mechanical properties. The study found that the sample was homogeneous and isotropic, and the estimated effective Young's modulus matched well with literature values.
Article
Nutrition & Dietetics
Frank Piva, Philippe Gervois, Youness Karrout, Famara Sane, Marie-Benedicte Romond
Summary: This study investigates the protective potential of Bifidobacterium longum cell wall lipoproteins (Lpps) in rheumatoid arthritis (RA) and finds that they can modulate the gut microbiota and alleviate arthritis symptoms. The dosage of Lpps is critical for preventing arthritis progression and appropriately modulating the microbiome. The results also suggest that Lpps may trigger the immune system.
Article
Cell Biology
Shaojian Chen, Zhihuan Luo, Xiaguang Chen
Summary: Research shows that Hsa_circ_0044235 is downregulated in rheumatoid arthritis patients and regulates NLRP3-mediated pyroptosis through the miR-135b-5p-SIRT1 axis to affect the development of RA.
Article
Engineering, Biomedical
Behrad Mahmoodi, Patricia Goggin, Christabel Fowler, Richard B. Cook
Summary: The study evaluated the impact of NovaMin and stannous fluoride (SnF2) on dentine tubule occlusion using serial block-face SEM (SBF-SEM). Results showed that NovaMin achieved better occlusion than SnF2, leading to increased mineral density and dentine mineralization. SBF-SEM demonstrates potential for high-resolution analysis of bone-like materials for research and development of new biomaterials.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Renpeng Zhou, Yong Chen, Shufang Li, Xin Wei, Weirong Hu, Suan Tang, Jie Ding, Wanjin Fu, Hailin Zhang, Fan Chen, Wenjuan Hao, Yi Lin, Rendi Zhu, Ke Wang, Lei Dong, Yingjie Zhao, Xiaowen Feng, Feihu Chen, Changhai Ding, Wei Hu
Summary: This study identified the role of TRPM7 channel-mediated chondrocyte ferroptosis in the destruction of articular cartilage associated with rheumatoid arthritis (RA). The findings suggest that TRPM7-mediated chondrocyte ferroptosis is a promising target for the prevention and treatment of RA through the PKC alpha-NOX4 axis.
Article
Biochemistry & Molecular Biology
Jianwei Xiao, Xu Cai, Rongsheng Wang, Weijian Zhou, Zhizhong Ye
Summary: This study analyzed the specific mechanism of NLRP3 in rheumatoid arthritis (RA). It was found that NLRP3 levels were increased in synovial tissues and fibroblast-like synoviocytes (FLS) of RA patients. Silencing NLRP3 suppressed FLS proliferation and inflammatory factor levels. Additionally, it was discovered that ALKBH5 binds with NLRP3 and its silencing also suppressed FLS proliferation and inflammatory factor levels, while NLRP3 overexpression neutralized the role of ALKBH5 in FLS. Furthermore, m6A modification induced by ALKBH5 suppressed NLRP3 mRNA level through YTHDC2 in RA, and NLRP3 was identified as a key factor in RA progression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yayun Xu, Zhuoyan Zai, Zheng Lu, Tao Zhang, Longfei Wang, Xuewen Qian, Jingjing Tao, Xiaoqing Peng, Yihao Zhang, Feihu Chen
Summary: The circCDKN2B-AS_006/miR-1258/RUNX1 axis plays a crucial role in promoting the tumor-like growth and metastasis of RASFs in rheumatoid arthritis. Inhibition of circCDKN2B-AS_006 expression alleviates arthritis severity and inhibits aggressive behaviors of RASFs in a mouse model. This study highlights the importance of circRNAs in the pathogenesis of RA and provides a potential therapeutic target for its treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Pedro Santos-Moreno, Gabriel-Santiago Rodriguez-Vargas, Rosangela Casanova, Jaime-Andres Rubio-Rubio, Josefina Chavez-Chavez, Diana Patricia Rivera-Triana, Ruth Alexandra Castiblanco-Montanez, Sandra Milena Hernandez-Zambrano, Laura Villareal, Adriana Rojas-Villarraga
Summary: This study evaluated a non-face-to-face-multidisciplinary consultation model in a population with rheumatoid arthritis (RA) during the COVID-19 pandemic. The results showed that there were no significant differences in disease stability between the telemedicine model and the usual face-to-face care or mixed model for RA patients. However, patients in the usual care group and the transition model group had decreased therapeutic adherence and increased self-care ability.
Article
Anesthesiology
Ahmed M. Elsaman, Ahmed Hamed, Ahmed R. Radwan
Summary: The study showed that DNB is effective in controlling local disease in active RA joints, with significant improvement in clinical and ultrasound scores at 2 and 8 weeks. Treatment effects were more pronounced in the dominant hand, with maximum improvement observed at 2 weeks in the injected PIPs, particularly in the second PIP. Early intervention led to better outcomes.
CLINICAL JOURNAL OF PAIN
(2021)
Review
Materials Science, Biomaterials
Andrea G. Marshall, Kit Neikirk, Dominique C. Stephens, Larry Vang, Zer Vue, Heather K. Beasley, Amber Crabtree, Estevao Scudese, Edgar Garza Lopez, Bryanna Shao, Evan Krystofiak, Sharifa Rutledge, Jaimaine Davis, Sandra A. Murray, Steven M. Damo, Prasanna Katti, Antentor Hinton
Summary: Serial block face scanning electron microscopy (SBF-SEM) is an advanced imaging technique that provides larger x- and y-axis ranges for three-dimensional visualization compared to other volumetric EM techniques. It was developed by Denk and Horstmann in 2004 as a method to resolve the 3D architecture of neuronal networks with nanometer resolution. This article provides an accessible overview of the advantages, challenges, applications, and potential future clinical use of SBF-SEM, as well as alternative AI-based segmentation methods.
Review
Immunology
Xiaoyu Xu, Miao Wang, Zikang Wang, Qian Chen, Xixuan Chen, Yingyue Xu, Min Dai, Bin Wu, Yanping Li
Summary: Gut microbiota dysbiosis may exacerbate rheumatoid arthritis (RA) through the gut-joint axis, but the specific regulatory mechanisms are still unclear.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Fatemeh Moadab, Hossein Khorramdelazad, Mitra Abbasifard
Summary: The CCL2/CCR2 axis plays a crucial role in the pathogenesis of rheumatoid arthritis, triggering various immunological events such as inflammation and being involved in multiple processes of RA development. Targeting the CCL2/CCR2 axis offers potential opportunities for immunotherapy in RA treatment.
Article
Genetics & Heredity
B. Liv Gansmo, A. Benedicte Lie, Marthe T. Maehlen, Lars Vatten, Pal Romundstad, Kristian Hveem, Per E. Lonning, Stian Knappskog
Summary: The study found a potential association between the MDM2 del1518 variant and the risk of rheumatoid arthritis, as well as indications that combinational genotypes and haplotypes in the MDM2 locus may be related to rheumatoid arthritis.
Article
Multidisciplinary Sciences
Malgorzata A. Sliwinska, Anna Caly, Jedrzej Szymanski, Kasia Radwanska
Summary: 3D electron microscopy offers nanoscale resolution for analyzing morphological parameters of dendritic spines, with features such as spine volume and PSD only observable with this technique. SBEM provides easier and more reproducible 3D EM data, while also reducing the number of animals needed for experimentation.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Biotechnology & Applied Microbiology
Qiang Fu, Mei-Jie Song, Jing Fang
Summary: This study reveals that the expression level of LncRNA OSER1-AS1 is significantly decreased in rheumatoid arthritis (RA) patients and may serve as a potential diagnostic marker. The overexpression of OSER1-AS1 inhibits the inflammatory response in RA through its interaction with miR-1298-5p and E2F1.
Article
Neurosciences
Shouta Sugio, Koujiro Tohyama, Shinichiro Oku, Kanehiro Fujiyoshi, Takeshi Yoshimura, Keigo Hikishima, Ryutaro Yano, Takahiro Fukuda, Masaya Nakamura, Hideyuki Okano, Masahiko Watanabe, Masaki Fukata, Kazuhiro Ikenaka, Kenji F. Tanaka
Article
Multidisciplinary Sciences
Fumio Yoshikawa, Yumi Sato, Koujiro Tohyama, Takumi Akagi, Tamio Furuse, Tetsushi Sadakata, Mika Tanaka, Yo Shinoda, Tsutomu Hashikawa, Shigeyoshi Itohara, Yoshitake Sano, M. Said Ghandour, Shigeharu Wakana, Teiichi Furuichi
Article
Neurosciences
Takahiro Shimizu, Wilaiwan Wisessmith, Jiayi Li, Manabu Abe, Kenji Sakimura, Banthit Chetsawang, Yoshinori Sahara, Koujiro Tohyama, Kenji F. Tanaka, Kazuhiro Ikenaka
Article
Biology
Eleni Kougioumtzidou, Takahiro Shimizu, Nicola B. Hamilton, Koujiro Tohyama, Rolf Sprengel, Hannah Monyer, David Attwell, William D. Richardson
Article
Biology
I. Lorena Arancibia-Carcamo, Marc C. Ford, Lee Cossell, Kinji Ishida, Koujiro Tohyama, David Attwell
Article
Neurosciences
Takamitsu Sano, Ayako Kohyama-Koganeya, Masami O. Kinoshita, Tetsuya Tatsukawa, Chika Shimizu, Eriko Oshima, Kazuyuki Yamada, Tung Dinh Le, Takumi Akagi, Koujiro Tohyama, Soichi Nagao, Yoshio Hirabayashi
NEUROSCIENCE RESEARCH
(2018)
Article
Multidisciplinary Sciences
Naomi Matsumoto, Mizuki Sekiya, Koujiro Tohyama, Eri Ishiyama-Matsuura, Ge-Hong Sun-Wada, Yoh Wada, Masamitsu Futai, Mayumi Nakanishi-Matsui
SCIENTIFIC REPORTS
(2018)
Article
Microbiology
Hong Zhao, Taiki Aoshi, Satoru Kawai, Yuki Mori, Aki Konishi, Muge Ozkan, Yukiko Fujita, Yasunari Haseda, Mikiko Shimizu, Masako Kohyama, Kouji Kobiyama, Kei Eto, Junichi Nabekura, Toshihiro Horii, Tomoko Ishino, Masao Yuda, Hiroaki Hemmi, Tsuneyasu Kaisho, Shizuo Akira, Manabu Kinoshita, Koujiro Tohyama, Yoshichika Yoshioka, Ken J. Ishii, Cevayir Coban
CELL HOST & MICROBE
(2014)
Article
Pathology
H. Fukuoka, J. Sasaki, H. Kamishina, R. Sato, J. Yasuda, M. Katayama, K. Tohyama, M. Ohshida, M. Goryo
JOURNAL OF COMPARATIVE PATHOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Wilaiwan Wisessmith Durose, Takahiro Shimizu, JiaYi Li, Manabu Abe, Kenji Sakimura, Banthit Chetsawang, Kenji F. Tanaka, Akio Suzumura, Koujiro Tohyama, Kazuhiro Ikenaka
JOURNAL OF NEUROCHEMISTRY
(2019)
Article
Neurosciences
Kaylene M. Young, Konstantina Psachoulia, Richa B. Tripathi, Sara-Jane Dunn, Lee Cossell, David Attwell, Koujiro Tohyama, William D. Richardson
Article
Multidisciplinary Sciences
Ian A. McKenzie, David Ohayon, Huiliang Li, Joana Paes de Faria, Ben Emery, Koujiro Tohyama, William D. Richardson
Article
Hematology
Shugo Kowata, Sumio Isogai, Kazunori Murai, Shigeki Ito, Koujiro Tohyama, Masatsugu Ema, Jiro Hitomi, Yoji Ishida
THROMBOSIS AND HAEMOSTASIS
(2014)
Article
Biochemistry & Molecular Biology
Takaoki Kasahara, Mie Kubota-Sakashita, Yasuko Nagatsuka, Yoshio Hirabayashi, Tomohito Hanasaka, Koujiro Tohyama, Tadafumi Kato
