Article
Biochemistry & Molecular Biology
Martina Derme, Maria Grazia Piccioni, Roberto Brunelli, Alba Crognale, Marika Denotti, Paola Ciolli, Debora Scomparin, Luigi Tarani, Roberto Paparella, Gianluca Terrin, Maria Di Chiara, Alessandro Mattia, Simona Nicotera, Alberto Salomone, Mauro Ceccanti, Marisa Patrizia Messina, Nunzia La Maida, Giampiero Ferraguti, Carla Petrella, Marco Fiore
Summary: Fetal alcohol spectrum disorder (FASD) is a set of conditions caused by prenatal alcohol exposure. It affects an estimated 2% to 5% of people in the United States and Western Europe. The exact mechanism of alcohol's impact on fetal development is unclear, but it involves decreased glutathione peroxidase action and increased production of reactive oxygen species (ROS), leading to oxidative stress. We report a case of a mother who abused alcohol, smoked cigarettes, and used cocaine during pregnancy, resulting in her newborn being diagnosed with FAS. The study highlights the importance of intensive hospital monitoring and controls for FASD cases.
Article
Multidisciplinary Sciences
Reyaz Ahmad Khan, Kangjam Rekha Devi, Manash Pratim Barman, Madhusmita Bhagawati, Rajeev Sarmah
Summary: Food habits and oral hygiene strongly influence the oral ecosystem. Consumption of intoxicating substances may affect the presence of pathogens and opportunistic pathogens in the oral cavity. Microbes were isolated from oral swabs of consumers and non-consumers, and the risk of occurrence of these organisms and health conditions were calculated. The study found a higher risk of oral cancer in individuals who chew tobacco.
Article
Biology
Ekaterina Efanova, Olga Bushueva, Roman Saranyuk, Anna Surovtseva, Mikhail Churnosov, Maria Solodilova, Alexey Polonikov
Summary: The aim of this pilot study was to investigate the association between single nucleotide polymorphisms (SNP) in the GCLC gene and the risk and clinical features of psoriasis. A total of 944 individuals, including patients with psoriasis and healthy controls, were recruited. The study found that certain SNPs in the GCLC gene were associated with susceptibility to psoriasis, earlier disease onset, specific skin lesion localizations, and other clinical features.
Review
Biochemistry & Molecular Biology
Ethan Read, Jiechun Zhu, Guangdong Yang
Summary: Hydrogen sulfide (H2S) as an antioxidant regulator in inflammatory diseases has sparked interest, with studies suggesting its potential role in preventing or reversing disease progression caused by smoking or alcohol use. There is an interrelationship between H2S signaling and smoking or alcohol consumption, and supplementation of H2S may be beneficial in treating or preventing diseases in addicted individuals.
Article
Medicine, General & Internal
Makedonka Atanasovska Velkovska, Katja Goricar, Tanja Blagus, Vita Dolzan, Barbara Cvenkel
Summary: The study found that GSTM1 gene deletion is associated with decreased risk of ocular hypertension, and genetic variability in IL1B and IL6 may be linked to glaucoma risk. Additionally, GPX and TNF genes may be associated with the glaucoma phenotype. This suggests potential new strategies and personalized treatment for glaucoma based on genetic factors.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ki-Heon Jeong, Su Kang Kim, Jong-Kil Seo, Min Kyung Shin, Mu-Hyoung Lee
Summary: Non-segmental vitiligo (NSV) is the most common type of vitiligo characterized by the loss of melanocytes. Genetic factors, specifically polymorphisms in the GZMB gene, have been found to be associated with autoimmune diseases and play a role in NSV susceptibility. Several SNPs in the GZMB gene showed significant association with NSV, suggesting a potential link between GZMB polymorphisms and NSV development.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Juan Pablo Meza-Espinoza, Valeria Peralta-Leal, Jorge Duran-Gonzalez, Nelly Macias-Gomez, Anabel Bocanegra-Alonso, Evelia Leal-Ugarte
Summary: The R399Q polymorphism of the XRCC1 gene is associated with colorectal cancer, while the R194W polymorphism does not show a significant association. However, further research is needed to verify the role of XRCC1 polymorphisms in the etiology of colorectal cancer.
Article
Pediatrics
Maristella Santi, Christa E. Fluck, Michael Hauschild, Beatrice Kuhlmann, Claudia E. Kuehni, Grit Sommer
Summary: Most women with Turner syndrome have a healthy lifestyle, such as not smoking and avoiding binge drinking, but only a minority engage in sufficient physical activity. Pediatricians should promote structured physical activity from early childhood to reduce future cardiovascular risks.
Review
Physiology
Sara Zieba, Mateusz Maciejczyk, Anna Zalewska
Summary: Alcohol abuse and smoking have been shown to have negative effects on the oral environment, including salivary gland dysfunction, DNA damage leading to precancerous lesions, and deterioration of periodontal health.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Zhongli Yang, Jiali Chen, Haijun Han, Yan Wang, Xiaoqiang Shi, Bin Zhang, Ying Mao, Andria N. Li, Wenji Yuan, Jianhua Yao, Ming D. Li
Summary: Through genome-wide sequencing analysis, a genetic variant in the ARVCF gene was found to be associated with nicotine dependence. Further experiments demonstrated that this variant regulates the expression of the ARVCF gene, and that ARVCF is a causal gene for nicotine dependence. Additionally, the deletion of the ARVCF gene was shown to impair learning and memory, and alleviate nicotine-induced memory deficits.
Article
Multidisciplinary Sciences
Mariah Jorda, Bradley J. Conant, Anne Sandstrom, Marilyn G. Klug, Jyoti Angal, Larry Burd
Summary: The risk of smoking and drinking during pregnancy can be prevented by factors such as living with someone, higher education levels, employment status, and mental well-being. These social factors play an important role in reducing substance use rates during pregnancy.
Article
Andrology
Hong-Yan Zhang, Yi Mu, Pan Chen, Dong-Dong Liu, Ke-Hang Chen, Qi Yu, Jun He, Fa Sun, Jun-Ping Xing, Kai-Fa Tang
Summary: This study explored the relationship between genetic polymorphisms of metabolic enzymes and idiopathic male infertility, and observed the efficacy of antioxidant therapy in these patients. The results showed that GSTM1 and GSTT1 gene deletions were more common in idiopathic male infertility, and these patients had lower sperm quality and higher oxidative damage levels. However, antioxidant therapy was not effective in male infertility patients with GSTM1 and GSTT1 gene deletions.
ASIAN JOURNAL OF ANDROLOGY
(2022)
Article
Cell Biology
Zhen Guo, Mei-Hua Bao, Yun-Xia Fan, Yan Zhang, Hai-Yan Liu, Xiao-Long Zhou, Ben Wu, Qing-Qing Lu, Bin-Sheng He, Xu-Ying Nan, Jiao-Yang Lu
Summary: The genetic polymorphisms of linc00312 may serve as potential biomarkers for NPC carcinogenesis and prognosis, as they can influence the expression and secondary structure of linc00312, thus affecting the sensitivity and survival of NPC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Mahdi Sheikh, Shama Virani, Hilary A. Robbins, Lenka Foretova, Ivana Holcatova, Vladimir Janout, Jolanta Lissowska, Marie Navratilova, Anush Mukeriya, Miodrag Ognjanovic, Beata Swiatkowska, David Zaridze, Paul Brennan
Summary: This study investigated the survival and prognostic factors of surgically-resected early-stage non-small cell lung cancer (NSCLC) in Central and Eastern Europe. The 5-year survival rate was 49.5%, and age, gender, weight loss, smoking, alcohol drinking, and tumor stage were associated with the risk of death. Smoking and alcohol drinking showed a dose-dependent association with cancer-specific mortality.
Article
Multidisciplinary Sciences
Maria Sabater Molina, Elisa Nicolas Rocamora, Asuncion Iborra Bendicho, Elisa Garcia Vazquez, Esther Zorio, Fernando Dominguez Rodriguez, Cristina Gil Ortuno, Ana Isabel Rodriguez, Antonio J. Sanchez-Lopez, Ruben Jara Rubio, Antonio Moreno-Docon, Pedro J. Marcos, Pablo Garcia Pavia, Roberto Barriales Villa, Juan R. Gimeno Blanes
Summary: This study found that several SNPs in the ACE2 gene are associated with the severity of COVID-19 in patients. Some SNPs show a protective effect, while others increase the risk of hospitalization and a more severe course of the disease. These findings suggest that genetic variations may play a significant role in the severity of COVID-19 infection.
Article
Medicine, Research & Experimental
Chung-Liang Li, Cheng-Che Wu, Jung-Yu Kan, Fang-Ming Chen, Ming-Feng Hou, Chieh-Han Chuang, Hsin- Huang, Fu Ou-Yang
Summary: This study examined the effectiveness of neoadjuvant chemotherapy in breast cancer patients of different age groups and found that elder patients had better survival outcomes after achieving pathological complete response (pCR), while younger patients had higher disease-free survival rates in non-pCR patients.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biology
Shi-Jer Lou, Ming-Feng Hou, Hong-Tai Chang, Hao-Hsien Lee, Chong-Chi Chiu, Shu-Chuan Jennifer Yeh, Hon-Yi Shi
Summary: This study analyzed machine-learning algorithms to predict 10-year survival after breast cancer surgery and found that preoperative physical and mental functioning assessments were the best predictors. The study compared the accuracy of five models and found that the deep neural network model performed the best.
Letter
Medicine, Research & Experimental
Chih-Ching Chin, Jun-Ping Shiau, Chi-Wen Luo, Ming-Feng Hou
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jun-Ping Shiau, Ya-Ting Chuang, Yuan-Bin Cheng, Jen-Yang Tang, Ming-Feng Hou, Ching-Yu Yen, Hsueh-Wei Chang
Summary: The critical factors for regulating cancer metabolism are oxidative stress and PI3K/AKT/mTOR. However, their effects on various metabolic mechanisms are complex. Natural product fucoidan has the potential to modulate oxidative stress and PI3K/AKT/mTOR and has anticancer properties. This review summarizes the roles of oxidative stress and PI3K/AKT/mTOR in metabolism and explores the potential application of fucoidan in metabolic regulation.
Article
Biochemistry & Molecular Biology
Ya-Ting Chuang, Jun-Ping Shiau, Ching-Yu Yen, Ming-Feng Hou, Jiiang-Huei Jeng, Jen-Yang Tang, Hsueh-Wei Chang
Summary: Combined treatment is a promising strategy for cancer therapy, but it may have adverse effects on normal cells. This study found that fucoidan (FN), a safe food ingredient derived from brown algae, has preferential antiproliferation effects on oral cancer cells. When combined with ultraviolet C (UVC) irradiation, FN effectively reduced the viability of oral cancer cells and induced higher levels of apoptosis, oxidative stress, and DNA damage compared to single treatments. This suggests that UVC/FN treatment has potential for targeted and synergistic antiproliferation in oral cancer therapy.
Article
Biochemistry & Molecular Biology
Jun-Ping Shiau, Ya-Ting Chuang, Jen-Yang Tang, Shu-Rong Chen, Ming-Feng Hou, Jiiang-Huei Jeng, Yuan-Bin Cheng, Hsueh-Wei Chang
Summary: This study aimed to evaluate the antiproliferative effects of methanol extract of T. swinhoei (METS) on oral cancer cells and compare its detailed responses to normal cells. The results showed that METS effectively inhibited the proliferation of oral cancer cells while not affecting normal cell viability, suggesting a preferential antiproliferative function. METS induced apoptosis, cellular and mitochondrial oxidative stress, and DNA damage in oral cancer cells, which could be reversed by an oxidative stress inhibitor. Additionally, METS activated both extrinsic and intrinsic caspases.
Review
Biochemistry & Molecular Biology
Jun-Ping Shiau, Ya-Ting Chuang, Jen-Yang Tang, Kun-Han Yang, Fang-Rong Chang, Ming-Feng Hou, Ching-Yu Yen, Hsueh-Wei Chang
Summary: Oxidative stress and AKT pathway play crucial roles in regulating various cell functions in cancer cells. Natural products have the potential to modulate oxidative stress and AKT for anticancer effects. However, the underlying mechanisms of how they regulate cell functions, particularly the contribution of AKT downstream effectors, are not well understood. This review discusses the roles of oxidative stress and AKT pathway in ten cell functions and highlights the potential of natural products in regulating these functions, with a focus on AKT effectors that have been rarely reported.
Review
Biochemistry & Molecular Biology
Meng-Chien Willie Hsieh, Wei-Ting Wang, Chuang-Yu Lin, Yur-Ren Kuo, Su-Shin Lee, Ming-Feng Hou, Yi-Chia Wu
Summary: This review summarizes the therapeutic benefits of using various types of stem cells, including embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, and adipose-derived stem cells, in diabetic wound healing. The focus is on autologous adipose-derived stem cells and laboratory expandable induced pluripotent stem cells. The study aims to shed more light on this attractive therapy in order to improve the efficacy of wound healing in diabetic patients.
Article
Biochemistry & Molecular Biology
Anupama Vadhan, Ming-Feng Hou, Priya Vijayaraghavan, Yi-Chia Wu, Stephen Chu-Sung Hu, Yun-Ming Wang, Tian-Lu Cheng, Yen-Yun Wang, Shyng-Shiou F. Yuan
Summary: CD44 plays a key role in breast cancer metastasis by downregulating nuclear FOXA2.
Article
Oncology
Huei-Yi Tsai, Tsung-Yu Tsai, Chia-Hui Wu, Wei-Shiuan Chung, Jo-Ching Wang, Jui-Sheng Hsu, Ming-Feng Hou, Ming-Chung Chou
Summary: This study explored the potential of a machine learning model integrating clinical and CT-based radiomics features to predict the pathologic complete response (pCR) to neoadjuvant systemic therapy (NST) in breast cancer patients. The results showed that integrating clinical data and radiomics features significantly improved model performance, achieving an accuracy of 0.87, compared to clinical (0.69) and radiomics (0.78) models. Furthermore, the use of more high-order textural features with high reproducibility further enhanced the model's performance. In conclusion, the integration of clinical and CT-based radiomics features was found to be helpful in predicting pCR to NST in breast cancer patients.
Review
Oncology
Ya-Ting Chuang, Jen-Yang Tang, Jun-Ping Shiau, Ching-Yu Yen, Fang-Rong Chang, Kun-Han Yang, Ming-Feng Hou, Ammad Ahmad Farooqi, Hsueh-Wei Chang
Summary: Cancer cells produce exosomes to regulate cell functions for tumor progression, and the modulation of exosome processing by natural products is not well understood. This review focuses on the organization of cancer-derived exosomal miRNAs and their processing and cell functions modulation by natural products. It provides a comprehensive understanding of the potential mechanisms and targets for exosome processing and cancer cell functions by natural products.
Article
Biochemistry & Molecular Biology
Chung-Yi Chen, Yan-Ning Chen, Jun-Ping Shiau, Jen-Yang Tang, Ming-Feng Hou, Hsueh-Wei Chang
Summary: This study found that 3HDT has an antiproliferative effect on triple-negative breast cancer cells, while having less impact on normal cells. Through various tests, it was found that 3HDT mainly acts on TNBC cells through oxidative stress and causes DNA damage. Therefore, 3HDT is an effective drug with selective antiproliferative and therapeutic effects on TNBC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tzu-Jung Yu, Jun-Ping Shiau, Jen-Yang Tang, Ammad Ahmad Farooqi, Yuan-Bin Cheng, Ming-Feng Hou, Chia-Hung Yen, Hsueh-Wei Chang
Summary: Physapruin A (PHA), a compound extracted from Physalis plants, can induce endoplasmic reticulum stress to regulate proliferation and apoptosis of breast cancer cells, which is associated with oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Jun-Ping Shiau, Ya-Ting Chuang, Ching-Yu Yen, Fang-Rong Chang, Kun-Han Yang, Ming-Feng Hou, Jen-Yang Tang, Hsueh-Wei Chang
Summary: This review aims to elucidate the relationship between natural products, miRNAs, and the AKT pathway in cancer cell development. By identifying the connections between miRNAs and the AKT pathway, as well as miRNAs and natural products, an miRNA/AKT/natural product axis was established to facilitate a better understanding of their anticancer mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Min-Yu Lee, Jun-Ping Shiau, Jen-Yang Tang, Ming-Feng Hou, Phoebe Sussana Primus, Chai-Lin Kao, Yeun-Mun Choo, Hsueh-Wei Chang
Summary: This study found that extracts from the traditional herb Boesenbergia plant in Southern Asia have anticancer effects on triple-negative breast cancer (TNBC) cells, and a new compound called StenB has been isolated. StenB suppresses the proliferation of TNBC cells by modulating oxidative stress and apoptosis signaling pathways, while showing little cytotoxicity to normal cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
