Article
Medical Laboratory Technology
Xinqi Cheng, Xiuzhi Guo, Xiaofeng Chai, Yingying Hu, Xiaolan Lian, Guojun Zhang
Summary: In this study, a case of interference in TSH measurements by heterophilic antibodies in a patient with thyroid papillary carcinoma after thyroidectomy was reported. By utilizing different assay platforms and pretreatment methods, it was confirmed that the presence of heterophilic antibodies can interfere with TSH measurements.
CLINICA CHIMICA ACTA
(2021)
Article
Endocrinology & Metabolism
Carla Moran, Nadia Schoenmakers, David Halsall, Susan Oddy, Greta Lyons, Sjoerd van den Berg, Mark Gurnell, Krishna Chatterjee
Summary: This article describes a diagnostic approach to discordant thyroid function tests, focusing on factors causing elevated free thyroxine and/or free triiodothyronine measurements with nonsuppressed TSH levels. A structured approach combining clinical assessment with additional laboratory investigations can establish a correct diagnosis, potentially preventing unnecessary investigation or inappropriate therapy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Tao Xu, Yanling Yang, Xing Huang, Jianhong Ren, Ting Xu, Wei Xie
Summary: Thyroid disease affects approximately 200 million people worldwide and is often associated with elevated blood lipid levels. A study on cynomolgus monkeys revealed that the changes in TSH and T3/T4 levels were correlated with lipid accumulation, with perturbations in numerous lipid species. The administration of SNA001 showed comparable effects on TSH, T3/T4 levels, and lipid profiles as the reference rhTSH (Thyrogen(R)), indicating a need for further exploration into the delayed responses observed in lipid levels after TSH stimulation.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Multidisciplinary Sciences
Yuji Shimizu, Shin-Ya Kawashiri, Yuko Noguchi, Yasuhiro Nagata, Takahiro Maeda, Naomi Hayashida
Summary: Anti-thyroid peroxidase antibody (TPO-Ab) is inversely associated with thyroid cysts, possibly indicating latent thyroid damage. The association between HbA1c and thyroid cysts showed an inverse correlation in participants with subclinical hypothyroidism.
Review
Biochemistry & Molecular Biology
Mirjana Babic Leko, Iva Juresko, Iva Rozic, Nikolina Pleic, Ivana Gunjaca, Tatijana Zemunik
Summary: Vitamin D is important for the normal functioning of organs, including the thyroid. Vitamin D deficiency is considered a risk factor for thyroid disorders, but the interaction between vitamin D and thyroid function is not fully understood. Studies comparing vitamin D status with thyroid function and the effect of vitamin D supplementation show inconsistent results, making it difficult to draw a definite conclusion. Additional studies with larger sample sizes are needed to fully understand the effect of vitamin D on thyroid function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Jingrong Liu, Chunxiao Yu, Luodan Han, Yiping Shen, Yao Fang, Yaokun Xia, Xu Yao, Fang Wu, Chunyan Li, Jinghua Chen, Xi Zhang, Jianming Lan
Summary: A wash-free biological aptasensor based on UCNPs and TAMRA was developed for high sensitive detection of TSH. The sensor achieved detection by changing the distance between UCNPs and TAMRA, and effectively eliminated background interference. With its high sensitivity and operational convenience, it is a promising method for clinical TSH determination.
Article
Endocrinology & Metabolism
Weibin Wang, Xingyun Su, Yongfeng Ding, Weina Fan, Weibin Zhou, Junwei Su, Zhendong Chen, Hong Zhao, Kaijin Xu, Qin Ni, Xiaowei Xu, Yunqing Qiu, Lisong Teng
Summary: Thyroid function abnormalities are common in COVID-19 patients, especially in severe cases. This might be partially explained by nonthyroidal illness syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Shaohan Li, Wenxing Guo, Qi Meng, Mei Zhu, Hongyan Wei, Fengying Ji, Long Tan, Wanqi Zhang
Summary: This study found a correlation between TSH levels and thyroid diseases in Chinese adults, with low TSH levels associated with an increased risk of TN and GR, while high TSH levels were associated with thyroid antibody positivity. The research suggests that adults with TSH levels at upper or lower limits of the normal range should be regularly reviewed.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Maximilian Zoltek, Therese M-L Andersson, Erland Axelsson, Christel Hedman, Catharina Ihre Lundgren
Summary: This study investigated the relationship between health anxiety and TSH-suppression treatment in patients with differentiated thyroid cancer (DTC). The results showed that health anxiety appears to be slightly higher among DTC patients compared to the general population, but it is not clearly connected to the TSH-suppression treatment.
Article
Cell Biology
Dong Lin, Ruijie Qin, Lixin Guo
Summary: DR is a common complication of diabetes, with high TSH levels being associated with an increased prevalence; TSH may regulate glucose-induced PCs loss through mitochondrial apoptosis involving TSHR.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Environmental Sciences
Liqin Hu, Hong Mei, Xiaonan Cai, Xijiang Hu, Zhengrong Duan, Jiuying Liu, Yafei Tan, Pan Yang, Han Xiao, Aifen Zhou
Summary: Thyroid hormones are crucial for fetal growth and neurodevelopment. The potential of paraben exposure to disrupt the endocrine system has caused concerns. However, the impact of maternal paraben exposure on newborn thyroid hormone levels is still largely unknown.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Endocrinology & Metabolism
Junpei Sanada, Fuminori Tatsumi, Shinji Kamei, Yoshiro Fushimi, Masashi Shimoda, Kenji Kohara, Shuhei Nakanishi, Kohei Kaku, Tomoatsu Mune, Hideaki Kaneto
Summary: Pituitary adenoma producing both growth hormone (GH) and thyroid-stimulating hormone (TSH) is rare but possible. This case study presented a 27-year-old woman with symptoms of acromegaly and simultaneous production of both GH and TSH by the pituitary adenoma. Treatment included pituitary tumor resection, cyber knife therapy, somatostatin analog, GH receptor antagonist, and anti-thyroid drug thiamazole.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Chao Hu, Yeqing Xu, Mingmin Wang, Shixuan Cui, Hangjun Zhang, Liping Lu
Summary: This study evaluated the disruption of thyroid endocrine by bisphenol analogues in mice, and found that these compounds can lead to thyroid dysfunction and glandular structural damage, further affecting the synthesis of thyroid hormones and physiological processes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Tongdao Xu, Ping Zhou, Huihua Li, Qun Ding, Fei Hua
Summary: The study found that TSHR was downregulated in bone marrow mesenchymal stem cells and its overexpression could accelerate osteogenic differentiation. MiR-577 was validated to target TSHR and inhibit BMSC osteogenic differentiation.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Marina Gabriela Birck, Bianca de Almeida-Pititto, Carolina C. P. S. Janovsky, Alessandra Carvalho Goulart, Itamar S. Santos, Patricia de Fatima dos Santos Teixeira, Jose A. Sgarbi, Sandhi M. Barreto, Bruce B. Duncan, Maria Ines Schmidt, Paulo A. Lotufo, Isabela M. Bensenor
Summary: This study investigated the relationship between thyroid function and the risk of developing diabetes. The results suggest that fT4 and fT3 levels, as well as their conversion ratio, may be associated with incident diabetes, especially in the presence of overweight or obesity. However, further studies are needed to confirm these findings.