Article
Medical Laboratory Technology
Jin Cheng, Danni Mu, Danchen Wang, Ling Qiu, Xinqi Cheng
Summary: Automated immunoassays used for evaluating parathyroid function are prone to various types of interference, which can have an impact on clinical practices. This review provides a comprehensive overview of six main types of interference affecting parathyroid hormone (PTH) measurement: heterophilic antibodies, biotin, PTH fragments, oxidized PTH (oxPTH), phosphorylated PTH, and certain preanalytical factors. The prevalence of some of these conditions has been reported to be as high as 11.7%, indicating a potentially significant problem due to the importance of parathyroid function testing. Identification of potential interference typically requires additional laboratory tests, such as method comparison and polyethylene glycol precipitation.
CLINICA CHIMICA ACTA
(2023)
Article
Endocrinology & Metabolism
Shaohan Li, Wenxing Guo, Qi Meng, Mei Zhu, Hongyan Wei, Fengying Ji, Long Tan, Wanqi Zhang
Summary: This study found a correlation between TSH levels and thyroid diseases in Chinese adults, with low TSH levels associated with an increased risk of TN and GR, while high TSH levels were associated with thyroid antibody positivity. The research suggests that adults with TSH levels at upper or lower limits of the normal range should be regularly reviewed.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Carla Moran, Nadia Schoenmakers, David Halsall, Susan Oddy, Greta Lyons, Sjoerd van den Berg, Mark Gurnell, Krishna Chatterjee
Summary: This article describes a diagnostic approach to discordant thyroid function tests, focusing on factors causing elevated free thyroxine and/or free triiodothyronine measurements with nonsuppressed TSH levels. A structured approach combining clinical assessment with additional laboratory investigations can establish a correct diagnosis, potentially preventing unnecessary investigation or inappropriate therapy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Deborah J. W. Lee, Soon Kieng Phua, Yali Liang, Claire Chen, Tar-Choon Aw
Summary: We evaluated the performance of the Abbott thyroid-stimulating hormone receptor antibody chemiluminescent microparticle immunoassay (CMIA) on the Alinity i. The results showed that the Abbott CMIA met the requirements for precision, linearity, analytical measuring range, limit of blank, limit of detection, limit of quantitation and diagnostic cut offs for Graves' disease. Thus, it is suitable for clinical use.
Article
Dermatology
Melis Gonulal, Kenan Teker, Aylin Ozturk, Fatma Y. Yasar
Summary: The study aimed to investigate the relationship between rosacea and thyroid diseases by analyzing thyroid blood tests and ultrasound findings of patients diagnosed with rosacea. It found no significant difference in thyroid-related laboratory parameters between the study groups, but anti-TPO levels differed significantly with increasing disease severity. Rosacea patients tended to have larger thyroid nodules and more heterogeneous thyroid parenchymas on ultrasound compared to controls.
DERMATOLOGIC THERAPY
(2021)
Article
Endocrinology & Metabolism
Yu Meng, Jing Lin, Jianxia Fan
Summary: This study aimed to identify the pregnancy-specific cutoff values for TPOAb positivity and TSH concentration associated with preterm delivery and develop a nomogram for risk prediction. The results showed that factors such as maternal age, history of premature delivery, elevated TSH concentration, and TPOAb positivity were associated with an increased risk of preterm delivery. The nomogram showed moderate discrimination and good calibration, indicating its potential as a clinical decision-making tool for predicting premature delivery.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuji Shimizu, Shin-Ya Kawashiri, Yuko Noguchi, Yasuhiro Nagata, Takahiro Maeda, Naomi Hayashida
Summary: Anti-thyroid peroxidase antibody (TPO-Ab) is inversely associated with thyroid cysts, possibly indicating latent thyroid damage. The association between HbA1c and thyroid cysts showed an inverse correlation in participants with subclinical hypothyroidism.
Article
Endocrinology & Metabolism
Geng-Dong Chen, Ting-Ting Pang, Xia-Fen Lu, Peng-Sheng Li, Zi-Xing Zhou, Shao-Xin Ye, Jie Yang, Xiu-Yin Shen, Dong-Xin Lin, Da-Zhi Fan, De-Mei Lu, Zheng-Ping Liu
Summary: Maternal thyroid function, specifically TSH concentrations, are associated with the risk of low birth weight in newborns. TSH concentrations of 2.5-4.0 mIU/L combined with TPO Ab- were linked to a lower risk of LBW, while TSH concentrations >4.0 mIU/L increased the risk of LBW. Subclinical hypothyroidism was found to be associated with a higher risk of LBW.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medical Laboratory Technology
Yao Hu, Jiajin Ni, Yi Cen, Buyue Zhang, Wenqing Wu, Wei Cheng, Mingying Huang, Ming Guan
Summary: The TSI assay demonstrated excellent analytical performance and high positive predictive value for GD. There was a high correlation between the quantitative results of the two methods, with a cutoff value of 0.7 IU/L obtained through ROC analysis for the TSI assay.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Obstetrics & Gynecology
Zhuqing Li, Shiru Xu, Wei Luo, Jingmei Hu, Tao Zhang, Xue Jiao, Yingying Qin
Summary: To investigate the association between thyroid autoimmunity (TAI) and ovarian reserve decline in euthyroid women, a case-control study was conducted. The results showed that TAI was not associated with low ovarian reserve in the whole population of euthyroid women, but it was significantly associated with overt premature ovarian insufficiency (POI) in women with TSH > 2.5 mu IU/ml.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Endocrinology & Metabolism
Kaikun Huang, Shaofei Su, Xueran Wang, Minhui Hu, Rong Zhao, Shen Gao, Enjie Zhang, Jianhui Liu, Shuanghua Xie, Yingyi Luan, Yongqing Sun, Yue Zhang, Wentao Yue, Ruixia Liu, Chenghong Yin
Summary: This study aimed to investigate the relationship between thyroid function and gestational diabetes mellitus (GDM). High TSH might be associated with an increased risk of GDM, and subclinical hypothyroidism was found to be related to the occurrence of GDM. Free thyroxine or thyroid peroxidase antibody, however, did not show any association with GDM.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Tao Xu, Yanling Yang, Xing Huang, Jianhong Ren, Ting Xu, Wei Xie
Summary: Thyroid disease affects approximately 200 million people worldwide and is often associated with elevated blood lipid levels. A study on cynomolgus monkeys revealed that the changes in TSH and T3/T4 levels were correlated with lipid accumulation, with perturbations in numerous lipid species. The administration of SNA001 showed comparable effects on TSH, T3/T4 levels, and lipid profiles as the reference rhTSH (Thyrogen(R)), indicating a need for further exploration into the delayed responses observed in lipid levels after TSH stimulation.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Endocrinology & Metabolism
Junpei Sanada, Fuminori Tatsumi, Shinji Kamei, Yoshiro Fushimi, Masashi Shimoda, Kenji Kohara, Shuhei Nakanishi, Kohei Kaku, Tomoatsu Mune, Hideaki Kaneto
Summary: Pituitary adenoma producing both growth hormone (GH) and thyroid-stimulating hormone (TSH) is rare but possible. This case study presented a 27-year-old woman with symptoms of acromegaly and simultaneous production of both GH and TSH by the pituitary adenoma. Treatment included pituitary tumor resection, cyber knife therapy, somatostatin analog, GH receptor antagonist, and anti-thyroid drug thiamazole.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Maximilian Zoltek, Therese M-L Andersson, Erland Axelsson, Christel Hedman, Catharina Ihre Lundgren
Summary: This study investigated the relationship between health anxiety and TSH-suppression treatment in patients with differentiated thyroid cancer (DTC). The results showed that health anxiety appears to be slightly higher among DTC patients compared to the general population, but it is not clearly connected to the TSH-suppression treatment.
Article
Oncology
Donald S. A. McLeod, Sheryl A. Bedno, David S. Cooper, Susan M. Hutfless, Silvia Ippolito, Susan J. Jordan, Peter G. Matos, Rachel E. Neale, Elena Sabini, David C. Whiteman, Paul W. Ladenson, Patrizio Caturegli
Summary: This case-control study conducted within the US active-duty personnel cohort found an association between longstanding prior thyroid autoimmunity and the risk of papillary thyroid cancer. The association was not mediated by the diagnosis of thyroid autoimmunity and thyroid cancers were often diagnosed at an early stage when autoimmunity had been identified.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)