Juvenile Myelomonocytic Leukemia: Molecular Pathogenesis Informs Current Approaches to Therapy and Hematopoietic Cell Transplantation

Fludarabine and Exposure-Targeted Busulfan Compares Favorably with Busulfan/Cyclophosphamide-Based Regimens in Pediatric Hematopoietic Cell Transplantation: Maintaining Efficacy with Less Toxicity

(2013) I.H. Bartelink et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Analysis of risk factors influencing outcomes after cord blood transplantation in children with juvenile myelomonocytic leukemia: a EUROCORD, EBMT, EWOG-MDS, CIBMTR study

(2013) F. Locatelli et al.   BLOOD

Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia

(2013) S. Gandre-Babbe et al.   BLOOD

Inhibition of SRC Corrects GM-CSF Hypersensitivity That Underlies Juvenile Myelomonocytic Leukemia

(2013) S. Bunda et al.   CANCER RESEARCH

Cytosine Arabinoside and Mitoxantrone Followed by Second Allogeneic Transplant for the Treatment of Children With Refractory Juvenile Myelomonocytic Leukemia

(2013) Sachit A. Patel et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia

(2013) Hirotoshi Sakaguchi et al.   NATURE GENETICS

Increased risk of gastrointestinal acute GVHD following the addition of melphalan to busulfan/cyclophosphamide conditioning

(2013) T. Mårtensson et al.   PEDIATRIC TRANSPLANTATION

Validation of flow cytometric phospho-STAT5 as a diagnostic tool for juvenile myelomonocytic leukemia

(2013) D Hasegawa et al.   Blood Cancer Journal

ConstitutionalNRASmutations are rare among patients with Noonan syndrome or juvenile myelomonocytic leukemia

(2012) Lilia Kraoua et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia

(2012) S. Doisaki et al.   BLOOD

Effects of spleen status on early outcomes after hematopoietic cell transplantation

(2012) G Akpek et al.   BONE MARROW TRANSPLANTATION

Short- and long-term risks of splenectomy for benign haematological disorders: should we revisit the indications?

(2012) Francesco Rodeghiero et al.   BRITISH JOURNAL OF HAEMATOLOGY

Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice

(2012) Tiffany Chang et al.   JOURNAL OF CLINICAL INVESTIGATION

Wiskott-Aldrich syndrome presenting with a clinical picture mimicking juvenile myelomonocytic leukaemia

(2012) Ayami Yoshimi et al.   PEDIATRIC BLOOD & CANCER

Outcomes of immunological interventions for mixed chimerism following allogeneic stem cell transplantation in children with juvenile myelomonocytic leukemia

(2012) Jiro Inagaki et al.   PEDIATRIC BLOOD & CANCER

Gene mutations in the Ras pathway and the prognostic implication in Korean patients with juvenile myelomonocytic leukemia

(2011) Hyung-Doo Park et al.   ANNALS OF HEMATOLOGY

Aberrant DNA methylation characterizes juvenile myelomonocytic leukemia with poor outcome

(2011) C. Olk-Batz et al.   BLOOD

Preemptive immunotherapy in childhood acute myeloid leukemia for patients showing evidence of mixed chimerism after allogeneic stem cell transplantation

(2011) E. Rettinger et al.   BLOOD

Chronic graft-versus-host disease: long-term results from a randomized trial on graft-versus-host disease prophylaxis with or without anti-T-cell globulin ATG-Fresenius

(2011) G. Socie et al.   BLOOD

A MEK Inhibitor Abrogates Myeloproliferative Disease in Kras Mutant Mice

(2011) N. Lyubynska et al.   Science Translational Medicine

Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus

(2010) Q. Li et al.   BLOOD

Spectrum of molecular defects in juvenile myelomonocytic leukaemia includesASXL1mutations

(2010) Yuka Sugimoto et al.   BRITISH JOURNAL OF HAEMATOLOGY

Myeloid Leukemia Development in c-Cbl RING Finger Mutant Mice Is Dependent on FLT3 Signaling

(2010) Chozhavendan Rathinam et al.   CANCER CELL

Gene Expression–Based Classification As an Independent Predictor of Clinical Outcome in Juvenile Myelomonocytic Leukemia

(2010) Silvia Bresolin et al.   JOURNAL OF CLINICAL ONCOLOGY

Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia

(2010) Charlotte M Niemeyer et al.   NATURE GENETICS

Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells

(2010) M. Naramura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intriguing response to azacitidine in a patient with juvenile myelomonocytic leukemia and monosomy 7

(2009) I. Furlan et al.   BLOOD

Mutations in CBL occur frequently in juvenile myelomonocytic leukemia

(2009) M. L. Loh et al.   BLOOD

Malignant Diseases in Noonan Syndrome and Related Disorders

(2009) Henrik Hasle   HORMONE RESEARCH

Standard graft-versus-host disease prophylaxis with or without anti-T-cell globulin in haematopoietic cell transplantation from matched unrelated donors: a randomised, open-label, multicentre phase 3 trial

(2009) Jürgen Finke et al.   LANCET ONCOLOGY

Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras

(2009) Jennifer O. Lauchle et al.   NATURE

Cytomegalovirus infection mimicking juvenile myelomonocytic leukemia showing hypersensitivity to granulocyte-macrophage colony stimulating factor

(2009) Hiroshi Moritake et al.   PEDIATRIC BLOOD & CANCER

Correlation of Clinical Features With the Mutational Status of GM-CSF Signaling Pathway-Related Genes in Juvenile Myelomonocytic Leukemia

(2009) Nao Yoshida et al.   PEDIATRIC RESEARCH

Twenty Years of Unrelated Donor Bone Marrow Transplantation for Pediatric Acute Leukemia Facilitated by the National Marrow Donor Program

(2008) Margaret L. MacMillan et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Once Daily i.v. Busulfan and Fludarabine (i.v. Bu-Flu) Compares Favorably with i.v. Busulfan and Cyclophosphamide (i.v. BuCy2) as Pretransplant Conditioning Therapy in AML/MDS

(2008) Borje S. Andersson et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Single-Cell Profiling Identifies Aberrant STAT5 Activation in Myeloid Malignancies with Specific Clinical and Biologic Correlates

(2008) Nikesh Kotecha et al.   CANCER CELL

Targeting Ras in Myeloid Leukemias

(2008) B. S. Braun et al.   CLINICAL CANCER RESEARCH

PTEN deficiency is a common defect in juvenile myelomonocytic leukemia

(2008) Yunying Lucy Liu et al.   LEUKEMIA RESEARCH

Juvenile myelomonocytic leukemia: A report from the 2nd International JMML Symposium

(2008) Rebecca J. Chan et al.   LEUKEMIA RESEARCH

Juvenile myelomonocytic leukemia with less aggressive clinical course and KRAS mutation

(2008) Masaru Imamura et al.   PEDIATRIC BLOOD & CANCER

A conditioning regimen of busulfan, fludarabine, and melphalan for allogeneic stem cell transplantation in children with juvenile myelomonocytic leukemia

(2008) Miharu Yabe et al.   PEDIATRIC TRANSPLANTATION