ConstitutionalNRASmutations are rare among patients with Noonan syndrome or juvenile myelomonocytic leukemia

Noonan syndrome and clinically related disorders

(2011) Marco Tartaglia et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner

(2011) J. Wang et al.   BLOOD

Clinical manifestations of mutations in RAS and related intracellular signal transduction factors

(2011) Martin Zenker   CURRENT OPINION IN PEDIATRICS

Noonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defects

(2011) V. Runtuwene et al.   Disease Models & Mechanisms

Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus

(2010) Q. Li et al.   BLOOD

Genetic typing of CBL, ASXL1, RUNX1, TET2 and JAK2 in juvenile myelomonocytic leukaemia reveals a genetic profile distinct from chronic myelomonocytic leukaemia

(2010) Benoîte Pérez et al.   BRITISH JOURNAL OF HAEMATOLOGY

RAS Mutations Contribute to Evolution of Chronic Myelomonocytic Leukemia to the Proliferative Variant

(2010) C. Ricci et al.   CLINICAL CANCER RESEARCH

Molecular and clinical analysis ofRAF1in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation

(2010) Tomoko Kobayashi et al.   HUMAN MUTATION

Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent Alterations in TET2, CBL, RAS, and RUNX1

(2010) Alexander Kohlmann et al.   JOURNAL OF CLINICAL ONCOLOGY

Noonan Syndrome: Clinical Features, Diagnosis, and Management Guidelines

(2010) A. A. Romano et al.   PEDIATRICS

Germ-line mutation of theNRASgene may be responsible for the development of juvenile myelomonocytic leukaemia

(2009) Paola De Filippi et al.   BRITISH JOURNAL OF HAEMATOLOGY

GermlineBRAFmutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: Molecular diversity and associated phenotypic spectrum

(2009) Anna Sarkozy et al.   HUMAN MUTATION

Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair

(2009) Viviana Cordeddu et al.   NATURE GENETICS

A restricted spectrum of NRAS mutations causes Noonan syndrome

(2009) Ion C Cirstea et al.   NATURE GENETICS

High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients

(2008) J. W. Tyner et al.   BLOOD

Clinical manifestations in patients with SOS1 mutations range from Noonan syndrome to CFC syndrome

(2008) Yoko Narumi et al.   JOURNAL OF HUMAN GENETICS

Lack of Cytoplasmic ERK Activation Is an Independent Adverse Prognostic Factor in Primary Cutaneous Melanoma

(2008) Braslav Jovanovic et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY