Potential Therapeutic Use of the Ketogenic Diet in Autism Spectrum Disorders

Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice

(2014) Johanne H. Ellenbroek et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dysregulation of the IGF-I/PI3K/AKT/mTOR signaling pathway in autism spectrum disorders

(2014) Jianling Chen et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Ketone body metabolism and its defects

(2014) Toshiyuki Fukao et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Ketogenic diets, mitochondria, and neurological diseases

(2014) Lindsey B. Gano et al.   JOURNAL OF LIPID RESEARCH

The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells

(2014) Sean David Hughes et al.   JOURNAL OF NEUROCHEMISTRY

Dietary treatment of epilepsy: rebirth of an ancient treatment

(2014) Sergiusz Jóźwiak et al.   Neurologia i Neurochirurgia Polska

Deficits in Bioenergetics and Impaired Immune Response in Granulocytes From Children With Autism

(2014) E. Napoli et al.   PEDIATRICS

Autism and Dietary Therapy

(2013) Martha R. Herbert et al.   JOURNAL OF CHILD NEUROLOGY

Galantamine efficacy and tolerability as an augmentative therapy in autistic children: A randomized, double-blind, placebo-controlled trial

(2013) Ali Ghaleiha et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Strong Genetic Influences on the Stability of Autistic Traits in Childhood

(2013) Karla Holmboe et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Acetylcholine Elevation Relieves Cognitive Rigidity and Social Deficiency in a Mouse Model of Autism

(2013) Golan Karvat et al.   NEUROPSYCHOPHARMACOLOGY

Ketogenic Diet Improves Core Symptoms of Autism in BTBR Mice

(2013) David N. Ruskin et al.   PLoS One

Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism

(2013) Eleonora Napoli et al.   Molecular Autism

Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder

(2013) R E Frye et al.   Translational Psychiatry

Alterations in mitochondrial DNA copy number and the activities of electron transport chain complexes and pyruvate dehydrogenase in the frontal cortex from subjects with autism

(2013) F Gu et al.   Translational Psychiatry

Dietary Therapies for Epilepsy

(2013) EricH Kossoff et al.   Biomedical Journal

Medium-chain Triglyceride Ketogenic Diet, An Effective Treatment for Drug-resistant Epilepsy and A Comparison with Other Ketogenic Diets

(2013) Yeou-meiChristiana Liu et al.   Biomedical Journal

Mammalian Target of Rapamycin (mTOR) Pathways in Neurological Diseases

(2013) Michael Wong   Biomedical Journal

Impairment of cortical GABAergic synaptic transmission in an environmental rat model of autism

(2012) Anwesha Banerjee et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Case Report of Pyruvate Dehydrogenase Deficiency With Unusual Increase of Fats During Ketogenic Diet Treatment

(2012) Veronica Di Pisa et al.   JOURNAL OF CHILD NEUROLOGY

Multiple Roles for Mammalian Target of Rapamycin Signaling in Both Glutamatergic and GABAergic Synaptic Transmission

(2012) M. C. Weston et al.   JOURNAL OF NEUROSCIENCE

Autistic-like behaviour in Scn1a +/− mice and rescue by enhanced GABA-mediated neurotransmission

(2012) Sung Han et al.   NATURE

Autism-related deficits via dysregulated eIF4E-dependent translational control

(2012) Christos G. Gkogkas et al.   NATURE

Mitochondrial Dysfunction in Pten Haplo-Insufficient Mice with Social Deficits and Repetitive Behavior: Interplay between Pten and p53

(2012) Eleonora Napoli et al.   PLoS One

Different Subtypes of GABA-A Receptors Are Expressed in Human, Mouse and Rat T Lymphocytes

(2012) Suresh K. Mendu et al.   PLoS One

A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism

(2012) P. B. S. Celestino-Soper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epilepsy in mitochondrial disorders

(2012) Josef Finsterer et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders

(2012) Carl E. Stafstrom et al.   Frontiers in Pharmacology

GABAergic Circuit Dysfunctions in Neurodevelopmental Disorders

(2012) Bidisha Chattopadhyaya et al.   Frontiers in Psychiatry

Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism

(2011) Joachim Hallmayer   ARCHIVES OF GENERAL PSYCHIATRY

Pyruvate dehydrogenase deficiency and epilepsy

(2011) Chitra Prasad et al.   BRAIN & DEVELOPMENT

Various indications for a modified Atkins diet in intractable childhood epilepsy

(2011) Yoon Mi Kim et al.   BRAIN & DEVELOPMENT

Epilepsy in autism: features and correlates

(2011) Patrick F. Bolton et al.   BRITISH JOURNAL OF PSYCHIATRY

The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway

(2011) Sharon S. McDaniel et al.   EPILEPSIA

Autism in Dravet syndrome: Prevalence, features, and relationship to the clinical characteristics of epilepsy and mental retardation

(2011) Bing-Mei Li et al.   EPILEPSY & BEHAVIOR

Modulation of oxidative stress and mitochondrial function by the ketogenic diet

(2011) Julie Milder et al.   EPILEPSY RESEARCH

A ketogenic diet impairs energy and glucose homeostasis by the attenuation of hypothalamic leptin signaling and hepatic insulin signaling in a rat model of non-obese type 2 diabetes

(2011) Sunmin Park et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures

(2011) D A Rossignol et al.   MOLECULAR PSYCHIATRY

Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

(2011) D A Rossignol et al.   MOLECULAR PSYCHIATRY

Dysregulation of mTOR Signaling in Neuropsychiatric Disorders: Therapeutic Implications

(2011) Kirsty Sawicka et al.   NEUROPSYCHOPHARMACOLOGY

Autophagy in health and disease. 5. Mitophagy as a way of life

(2010) Roberta A. Gottlieb et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial fatty acid oxidation and oxidative stress: Lack of reverse electron transfer-associated production of reactive oxygen species

(2010) Peter Schönfeld et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Autism and epilepsy: Historical perspective

(2010) Roberto Tuchman et al.   BRAIN & DEVELOPMENT

Cholinergic Abnormalities in Autism

(2010) Stephen I. Deutsch et al.   CLINICAL NEUROPHARMACOLOGY

Ketogenic diet slows down mitochondrial myopathy progression in mice

(2010) Sofia Ahola-Erkkilä et al.   HUMAN MOLECULAR GENETICS

Mitochondrial Dysfunction in Autism

(2010) Cecilia Giulivi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Ketones prevent synaptic dysfunction induced by mitochondrial respiratory complex inhibitors

(2010) Do Young Kim et al.   JOURNAL OF NEUROCHEMISTRY

Distinct Retinal Deficits in a Zebrafish Pyruvate Dehydrogenase-Deficient Mutant

(2010) C. M. Maurer et al.   JOURNAL OF NEUROSCIENCE

Follow-up of a child with pyruvate dehydrogenase deficiency on a less restrictive ketogenic diet

(2010) Areeg H. El-Gharbawy et al.   MOLECULAR GENETICS AND METABOLISM

Acute oxidative stress and systemic Nrf2 activation by the ketogenic diet

(2010) Julie B. Milder et al.   NEUROBIOLOGY OF DISEASE

Glucose transporter type 1 deficiency: Ketogenic diet in three patients with atypical phenotype

(2009) Pierangelo Veggiotti et al.   BRAIN & DEVELOPMENT

Neurometabolic disorders and dysfunction in autism spectrum disorders

(2009) Nassim Zecavati et al.   Current Neurology and Neuroscience Reports

A modern approach to the treatment of mitochondrial disease

(2009) Sumit Parikh et al.   Current Treatment Options in Neurology

Pyruvate dehydrogenase complex deficiency: four neurological phenotypes with differing pathogenesis

(2009) CHRISTINE BARNERIAS et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Improvement in motor and exploratory behavior in Rett syndrome mice with restricted ketogenic and standard diets

(2009) John G. Mantis et al.   EPILEPSY & BEHAVIOR

Ketogenic diet for the treatment of catastrophic epileptic encephalopathies in childhood

(2009) Giangennaro Coppola et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism

(2009) S. Jill James et al.   FASEB JOURNAL

Ketogenic Diets: An Update for Child Neurologists

(2009) Eric H. Kossoff et al.   JOURNAL OF CHILD NEUROLOGY

Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders

(2009) Y Zhao et al.   MOLECULAR PSYCHIATRY

Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism

(2008) S Jill James et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The Autistic Neuron: Troubled Translation?

(2008) Raymond J. Kelleher et al.   CELL

The ketogenic diet: Uses in epilepsy and other neurologic illnesses

(2008) Kristin W. Barañano et al.   Current Treatment Options in Neurology

Ketogenic diet: Stoking energy stores and still posing questions

(2008) Ina Knerr et al.   EXPERIMENTAL NEUROLOGY

Management and Risk Factors for Dyslipidemia With the Ketogenic Diet

(2008) Junaid Nizamuddin et al.   JOURNAL OF CHILD NEUROLOGY

The ketogenic diet increases mitochondrial glutathione levels

(2008) Stuart G. Jarrett et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial Disease in Autism Spectrum Disorder Patients: A Cohort Analysis

(2008) Jacqueline R. Weissman et al.   PLoS One

Modified Atkins diet to children and adolescents with medical intractable epilepsy

(2008) Susanne Weber et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

A ketogenic diet rescues the murine succinic semialdehyde dehydrogenase deficient phenotype

(2007) Kirk Nylen et al.   EXPERIMENTAL NEUROLOGY