Journal
COATINGS
Volume 8, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/coatings8090294
Keywords
topography; nanochannels; osteoblast; macrophage; osteoclast
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Funding
- Romanian Ministry of National Education, CNCS-UEFISCDI [PED 97/2017]
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Based on previously reported findings showing reduced foreign body reactions on nanochannelar topography formed on TiZr alloy, this study explores the in vitro effects of such a nanostructured surface on cells relevant for implant osseointegration, namely osteoblasts and osteoclasts. We show that such nanochannelar surfaces sustain adhesion and proliferation of mouse pre-osteoblast MC3T3-E1 cells and enhance their osteogenic differentiation. Moreover, this specific nanotopography inhibits nuclear factor kappa-B ligand (RANKL)-mediated osteoclastogenesis. The nanochannels' dual mode of action on the bone-derived cells could contribute to an enhanced bone formation around the bone implants. Therefore, these results warrant further investigation for nanochannels' use as surface coatings of medical implant materials.
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