Article
Genetics & Heredity
Ranjan Kumar Maji, Beate Czepukojc, Michael Scherer, Sascha Tierling, Cristina Cadenas, Kathrin Gianmoena, Nina Gasparoni, Karl Nordstroem, Gilles Gasparoni, Stephan Laggai, Xinyi Yang, Anupam Sinha, Peter Ebert, Maren Falk-Paulsen, Sarah Kinkley, Jessica Hoppstaedter, Ho-Ryun Chung, Philip Rosenstiel, Jan G. Hengstler, Joern Walter, Marcel H. Schulz, Sonja M. Kessler, Alexandra K. Kiemer
Summary: In this study, the effects of a high-fat and alcohol-containing diet on epigenetic aging in mouse hepatocytes were investigated using a multi-omics approach. Four gene network clusters associated with steatosis were identified, and specific transcription factors that may modulate these clusters were predicted. Additionally, four CpG loci linked to aging-related differential methylation were discovered, which showed minimal overlap with altered methylation in steatosis.
EPIGENETICS & CHROMATIN
(2023)
Article
Multidisciplinary Sciences
Jincheng Long, James Walker, Wenjing She, Billy Aldridge, Hongbo Gao, Samuel Deans, Martin Vickers, Xiaoqi Feng
Summary: The study reveals the molecular mechanism of DNA methylation reprogramming in plant male germline. Small interfering RNAs (siRNAs) synthesized by meiocyte nurse cells establish genic methylation and safeguard genome integrity through tapetal siRNAs.
Article
Dermatology
Qiuming Yao, Charles B. Epstein, Samridhi Banskota, Robbyn Issner, Yuhree Kim, Bradley E. Bernstein, Luca Pinello, Maryam M. Asgari
Summary: The study identified unique and shared epigenetic alterations in histone modifications in BCC and SCC, with specific biological pathways enriched in each subtype. Furthermore, transcription factors including SMAD, JDP2, and FOXP1 were found to play significant roles in the pathogenesis of BCC and SCC.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sarah S. Wang, Jihao Xu, Keely Y. Ji, Chang-Il Hwang
Summary: Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDA), is a significant cause of cancer-related deaths in the United States. While genetic mutations driving PDA initiation and progression have been identified, the mechanisms underlying PDA metastasis remain elusive. It is suggested that epigenetic fluctuations may play a critical role in driving PDA metastasis.
Article
Multidisciplinary Sciences
M. Ali Al-Radhawi, Shubham Tripathi, Yun Zhang, Eduardo D. Sontag, Herbert Levine
Summary: In this paper, the authors investigate the complex interactions between epigenetic marks, external signals, and gene-regulatory elements that lead to the emergence and transitions between distinct phenotypes in isogenic cells. They propose a mathematical modeling framework that considers both local and global competition effects between antagonistic epigenetic regulators, as well as the influence of local transcription factors. Applying this approach to experimental findings on the epithelial-mesenchymal transition, they are able to explain the observed data and provide verifiable predictions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Emily Catherine Cheung, Matthew Wyatt Kay, Kathryn Jaques Schunke
Summary: Pediatric obstructive sleep apnea has negative impacts on health and behavior in childhood, as well as increasing the risk for chronic adult diseases. There is growing evidence that epigenetic mechanisms may play a significant role in the development of adult diseases originating from early life insults.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Paul Cheng, Robert C. Wirka, Lee Shoa Clarke, Quanyi Zhao, Ramendra Kundu, Trieu Nguyen, Surag Nair, Disha Sharma, Hyun-jung Kim, Huitong Shi, Themistocles Assimes, Juyong Brian Kim, Anshul Kundaje, Thomas Quertermous
Summary: This study identifies ZEB2 as a new CAD genome-wide association study gene that affects features of plaque vulnerability through direct effects on the epigenome, providing a new therapeutic approach to target vascular disease.
Review
Pharmacology & Pharmacy
Erina Sugita, Kaori Hayashi, Akihito Hishikawa, Hiroshi Itoh
Summary: Epigenetic alterations in podocytes are associated with chronic kidney disease, including diabetic nephropathy. Detection of these changes may serve as a promising strategy for estimating kidney damage and prognosis. Targeting epigenetic podocyte changes and associated DNA damage could be a novel therapeutic approach for preventing progression to end-stage renal disease in diabetic nephropathy patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Min Huang, Qiang Wu, Zhi-Hong Jiang
Summary: This article reviews recent studies on the effects of oxidative stress on DNA and histone modifications in stem cells, and suggests that epigenetic alterations and oxidative stress may influence each other in stem cells.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Multidisciplinary Sciences
Matthew Naish, Michael Alonge, Piotr Wlodzimierz, Andrew J. Tock, Bradley W. Abramson, Anna Schmuecker, Terezie Mandakova, Bhagyshree Jamge, Christophe Lambing, Pallas Kuo, Natasha Yelina, Nolan Hartwick, Kelly Colt, Lisa M. Smith, Jurriaan Ton, Tetsuji Kakutani, Robert A. Martienssen, Korbinian Schneeberger, Martin A. Lysak, Frederic Berger, Alexandros Bousios, Todd P. Michael, Michael C. Schatz, Ian R. Henderson
Summary: The study used long-read sequencing to assemble the Arabidopsis genome and resolve all five centromeres. It found that centromeres consist of megabase-scale tandemly repeated satellite arrays and are invaded by retrotransposons. The centromeres are evolving through cycles of satellite homogenization and retrotransposon-driven diversification.
Article
Medicine, Research & Experimental
Elina Alaterre, Sara Ovejero, Laurie Herviou, Hugues de Boussac, Giorgio Papadopoulos, Marta Kulis, Stephanie Boireau, Nicolas Robert, Guilhem Requirand, Angelique Bruyer, Guillaume Cartron, Laure Vincent, Anne Marie Martinez, Jose Ignacio Martin-Subero, Giacomo Cavalli, Jerome Moreaux
Summary: This study explores the epigenetic landscape of multiple myeloma (MM) cells through analyzing histone modifications. The findings reveal links between histone modifications and cytogenetic abnormalities or recurrent mutations, and identify super-enhancers and promoters associated with MM biology and potential tumor suppressor functions. Additionally, regions involved in drug resistance are identified through analysis of H3K4me3 marks. The study also proposes risk scores and epigenetic biomarkers as new tools for precision medicine in MM.
Article
Biochemistry & Molecular Biology
Akihiko Sakashita, Masatoshi Ooga, Kai Otsuka, So Maezawa, Chikara Takeuchi, Sayaka Wakayama, Teruhiko Wakayama, Satoshi H. Namekawa
Summary: Sperm chromatin retains small amounts of histones, and chromatin states of sperm mirror gene expression programs of the next generation. In this study, researchers developed a mouse model where the deposition of Polycomb repressive complex 2 (PRC2)-mediated H3K27me3 is attenuated in the paternal germline and found that SCML2 is required for the establishment of the sperm epigenome. Dysregulated gene expression in the male germline and preimplantation embryos of mutant-derived wild-type F1 was observed. These findings provide functional evidence for the role of Polycomb in paternal epigenetic inheritance through sperm chromatin.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Developmental Biology
Nicoletta Tarozzi, Marco Nadalini, Giovanni Coticchio, Carlotta Zaca, Cristina Lagalla, Andrea Borini
Summary: Sperm is crucial for reconstitution of embryonic diploidy and specialized developmental functions. It triggers activation through PLC-zeta after gamete fusion, impacting fertilization and chromosome segregation. Sperm-specific epigenetic factors also contribute to embryonic development and have implications for assisted reproduction treatments.
MOLECULAR HUMAN REPRODUCTION
(2021)
Review
Multidisciplinary Sciences
Ipek Selcen, Emily Prentice, Patrizia Casaccia
Summary: This passage focuses on the epigenetic landscape of oligodendrocyte lineage cells, which refers to the cell-specific modifications of DNA, chromatin, and RNA that define a unique gene expression pattern of functionally specialized cells. It discusses the epigenetic changes occurring as progenitors differentiate into myelin-forming cells and respond to the local environment, including modifications of DNA, RNA, nucleosomal histones, chromatin organization, and local remodeling. The passage also explores the relationship between epigenetic modulators and RNA processing, as well as the reciprocal relationship between the epigenome and cell nucleus mechanical properties.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Review
Developmental Biology
Nicoletta Tarozzi, Marco Nadalini, Giovanni Coticchio, Carlotta Zaca, Cristina Lagalla, Andrea Borini
Summary: Sperm is essential for embryonic development, playing roles in activation, development, chromosome segregation, and more. Sperm's contribution to development goes beyond just fertilization, with implications for embryo health and assisted reproduction treatments.
MOLECULAR HUMAN REPRODUCTION
(2021)
