Review
Biochemistry & Molecular Biology
Felicity J. Emerson, Siu Sylvia Lee
Summary: This review discusses the current state of research on chromatin and aging, with a focus on chromatin factors related to longevity that have been discovered in model organisms. High-resolution genomics tools have allowed researchers to study the chromatin environment and its impact on lifespan with greater precision.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biology
Gabriel A. Guerrero, Maxime J. Derisbourg, Felix A. M. C. Mayr, Laura E. Wester, Marco Giorda, J. Eike Dinort, Matias D. Hartman, Klara Schilling, Maria Jose Alonso-De Gennaro, Ryan J. Lu, Berenice A. Benayoun, Martin S. Denzel
Summary: The study found that osm-3 mutants exhibit strong resistance to tunicamycin-induced ER stress, which is not dependent on the longevity factor DAF-16/FOXO. In addition, osm-3 mutants also show protection against bacterial pathogens, and the expression of xenobiotic detoxification genes is significantly elevated in these mutants.
Article
Geriatrics & Gerontology
Mohamad D. Bairakdar, Ambuj Tewari, Matthias C. Truttmann
Summary: This study conducted a systematic meta-analysis of over 1200 transcriptomic datasets related to aging in C. elegans, identifying potential pro-longevity genes using both differential expression analyses and machine learning approaches. However, the study also found that inter-lab experimental variance poses a challenge to the application of machine learning algorithms, indicating the need for more sophisticated batch correction strategies or standardized input data.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Cell Biology
Sangsoon Park, Murat Artan, Dae-Eun Jeong, Hae-Eun H. Park, Heehwa G. Son, Sieun S. Kim, Yoonji Jung, Yunji Choi, Jin I. Lee, Kyuhyung Kim, Seung-Jae V. Lee
Summary: This study identified food-derived chemical signals, such as diacetyl and the odor of lactic acid bacteria, that can influence the lifespan of Caenorhabditis elegans by reducing the activity of DAF-16/FOXO, a life-extending transcription factor. The findings suggest that food-derived odorants may play a role in shortening lifespan through binding to unidentified receptors.
Article
Multidisciplinary Sciences
Phillip A. Frankino, Talha F. Siddiqi, Theodore Bolas, Raz Bar-Ziv, Holly K. Gildea, Hanlin Zhang, Ryo Higuchi-Sanabria, Andrew Dillin
Summary: The transcription factor SKN-1/NRF2 can sense and respond to changes in metabolic state. Knockdown of the amidohydrolase T12A2.1/amdh-1 activates a unique subset of SKN-1 regulated genes, independent of P38-MAPK signaling components. Histidine catabolism genes are required for this activation, possibly through accumulation of a specific catabolite. Activating SKN-1 results in increased oxidative stress resistance but decreased survival to heat stress.
Article
Cell Biology
Hadi Tabarraei, Brandon M. Waddell, Kelly Raymond, Sydney M. Murray, Ying Wang, Keith P. Choe, Cheng-Wei Wu
Summary: CCR4-NOT is a versatile eukaryotic protein complex that regulates gene expression at multiple steps. This study shows that a subunit of CCR4-NOT, ccf-1, is required for the transcriptional response to cadmium and acrylamide stress in C. elegans. Knockdown of ccf-1 attenuates the activation of stress-protective genes, leading to decreased stress resistance and lifespan in C. elegans.
Article
Cell Biology
Rola S. Zeidan, Sung Min Han, Christiaan Leeuwenburgh, Rui Xiao
Summary: Iron plays crucial roles in physiological processes and its homeostasis involves a complex network of regulators at systemic, cellular, and molecular levels. Dysregulation of iron homeostasis is often linked to age-related pathologies, highlighting the importance of understanding the interplay between iron balance and aging in order to develop therapeutic strategies for age-related diseases.
AGEING RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Yizhou Jiang, Uma Gaur, Zhibai Cao, Sheng-Tao Hou, Wenhua Zheng
Summary: This study found that quetiapine shortened the lifespan of C. elegans by acting on dopamine D2 receptors and the mTOR signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Tatsuya Shioda, Ittetsu Takahashi, Kensuke Ikenaka, Naonobu Fujita, Tomotake Kanki, Toshihiko Oka, Hideki Mochizuki, Adam Antebi, Tamotsu Yoshimori, Shuhei Nakamura
Summary: Accumulating evidence suggests that the molecular network involving neuronal MML-1 function is crucial for regulating systemic aging. This study demonstrates that MML-1 and its heterodimer partners play a primary role in neurons to extend longevity in germlineless animals, acting via downstream cascades that are distinct from HLH-30. The MML-1-GLT-5 axis in neurons is critical for maintaining proteostasis and reducing oxidative stress in long-lived animals through autophagy and peroxidase MLT-7, respectively.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Stuart Maudsley, Deborah Walter, Claudia Schrauwen, Nore Van Loon, Irem Harputluoglu, Julia Lenaerts, Patricia McDonald
Summary: G protein-coupled receptors (GPCRs) are a diverse class of transmembrane proteins that are involved in almost every physiological process. They are also important targets for therapeutic drugs. GPCRs may play a central role in the development of various human diseases through their control of the molecular aging process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Katerina K. Yamamoto, Cathy Savage-Dunn
Summary: This article summarizes the roles of transforming growth factor-beta (TGF-beta) signaling in aging and immunity, highlighting the significance of using Caenorhabditis elegans as a research model.
FRONTIERS IN GENETICS
(2023)
Article
Cell Biology
Runshuai Zhang, Jinan Fang, Ting Qi, Shihao Zhu, Luxia Yao, Guicun Fang, Yunsheng Li, Xiao Zang, Weina Xu, Wanyu Hao, Shouye Liu, Dan Yang, Di Chen, Jian Yang, Xianjue Ma, Lianfeng Wu
Summary: Maternal age at childbearing has a conserved effect on offspring adult traits, as revealed in humans, Drosophila, and Caenorhabditis elegans. Using C. elegans, we found that aging mothers transmit abnormal mitochondria to offspring, but these mitochondria are rejuvenated in early life through an AMPK-dependent mechanism. Furthermore, we showed that mitochondrial dysfunction activates AMPK, which in turn activates TGF-β signaling to increase offspring adult size.
Article
Biology
Meng Huang, Minjie Hong, Xinhao Hou, Chengming Zhu, Di Chen, Xiangyang Chen, Shouhong Guang, Xuezhu Feng
Summary: The study identified a class of putative histone 3 lysine 9 mono/dimethyltransferase genes mutations that induce synergistic lifespan extension in Caenorhabditis elegans, increasing resistance to oxidative and heat stress, depending on the transcription factor DAF-16. Treatment with a specific inhibitor also resulted in similar effects.
Article
Genetics & Heredity
Nikolaos Tataridas-Pallas, Maximillian A. Thompson, Alexander Howard, Ian Brown, Marina Ezcurra, Ziyun Wu, Isabel Goncalves Silva, Christopher D. Saunter, Timo Kuerten, David Weinkove, T. Keith Blackwell, Jennifer M. A. Tullet
Summary: Feeling hunger or fullness is regulated by the integration of the sensory nervous system with physiological and metabolic cues, maintaining homeostasis and preventing disease. SKN-1B, identified as a central food-responsive node in C. elegans, controls satiety and metabolic homeostasis by modulating endocrine signaling pathways and promoting a robust mitochondrial network. This study suggests a new role for mammalian Nrf proteins in food sensing and satiety.
Article
Chemistry, Medicinal
Jing-Shan Wu, Chun-Guo Lin, Chang-Long Jin, Yan-Xia Zhou, Ying-Xiu Li
Summary: The marine bacterium Planococcus maritimu ML1206 was found to have antioxidant properties and could enhance the ability of nematodes to resist oxidative stress and extend their lifespan. These findings suggest that ML1206 has potential anti-aging and antioxidant functions and could be used in aquaculture and as a dietary supplement.