Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma
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Title
Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma
Authors
Keywords
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Journal
OncoImmunology
Volume 2, Issue 12, Pages e27090
Publisher
Informa UK Limited
Online
2014-01-25
DOI
10.4161/onci.27090
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- Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells
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