Why do human B cells secrete granzyme B? Insights into a novel B-cell differentiation pathway

Non-cytotoxic antiviral activities of granzymes in the context of the immune antiviral state

(2015) Felipe Andrade   IMMUNOLOGICAL REVIEWS

B-Cell Cross-Presentation of Autologous Antigen Precipitates Diabetes

(2012) E. Marino et al.   DIABETES

Activated Mouse B Cells Lack Expression of Granzyme B

(2012) M. Hagn et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection

(2012) J Loebbermann et al.   Mucosal Immunology

IFN-  enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing

(2011) F. Spadaro et al.   BLOOD

A quarter century of granzymes

(2011) C L Ewen et al.   CELL DEATH AND DIFFERENTIATION

Human B cells differentiate into granzyme B-secreting cytotoxic B lymphocytes upon incomplete T-cell help

(2011) Magdalena Hagn et al.   IMMUNOLOGY AND CELL BIOLOGY

Granzyme B Regulates Antiviral CD8+ T Cell Responses

(2011) S. M. Salti et al.   JOURNAL OF IMMUNOLOGY

Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

(2011) Inna S. Afonina et al.   MOLECULAR CELL

CD5+ B cells from individuals with systemic lupus erythematosus express granzyme B

(2010) Magdalena Hagn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD20+ B Cells: The Other Tumor-Infiltrating Lymphocytes

(2010) B. H. Nelson   JOURNAL OF IMMUNOLOGY

Sepsis Alters the Megakaryocyte–Platelet Transcriptional Axis Resulting in Granzyme B–mediated Lymphotoxicity

(2009) Robert J. Freishtat et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Suppressive functions of activated B cells in autoimmune diseases reveal the dual roles of Toll-like receptors in immunity

(2009) Vicky Lampropoulou et al.   IMMUNOLOGICAL REVIEWS

Granzyme B is expressed in urothelial carcinoma and promotes cancer cell invasion

(2009) Donatella D'Eliseo et al.   INTERNATIONAL JOURNAL OF CANCER

Human B Cells Secrete Granzyme B When Recognizing Viral Antigens in the Context of the Acute Phase Cytokine IL-21

(2009) M. Hagn et al.   JOURNAL OF IMMUNOLOGY

The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals

(2009) K. Yanaba et al.   JOURNAL OF IMMUNOLOGY

Granule-associated serine proteases: granzymes might not just be killer proteases

(2009) Christopher J. Froelich et al.   TRENDS IN IMMUNOLOGY

Interleukin 21 as a target of intervention in autoimmune disease

(2008) R Ettinger et al.   ANNALS OF THE RHEUMATIC DISEASES

The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer

(2008) Rosanne Spolski et al.   CURRENT OPINION IN IMMUNOLOGY

Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response

(2008) Sunil S. Metkar et al.   IMMUNITY

A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory Responses

(2008) Koichi Yanaba et al.   IMMUNITY

The role of IL-21 in regulating B-cell function in health and disease

(2008) Rachel Ettinger et al.   IMMUNOLOGICAL REVIEWS

Regulatory B cells as inhibitors of immune responses and inflammation

(2008) Jean-David Bouaziz et al.   IMMUNOLOGICAL REVIEWS

Antihemostatic Activity of Human Granzyme B Mediated by Cleavage of von Willebrand Factor

(2008) Marguerite S. Buzza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin 21: a cytokine/cytokine receptor system that has come of age

(2008) Warren J. Leonard et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I

(2008) Tiziana Di Pucchio et al.   NATURE IMMUNOLOGY

Tumor-Infiltrating T Cells Correlate with NY-ESO-1-Specific Autoantibodies in Ovarian Cancer

(2008) Katy Milne et al.   PLoS One

Noncytotoxic Lytic Granule-Mediated CD8+ T Cell Inhibition of HSV-1 Reactivation from Neuronal Latency

(2008) J. E. Knickelbein et al.   SCIENCE

Non-apoptotic functions of granzymes

(2008) V. Romero et al.   TISSUE ANTIGENS

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

(2007) Rosanne Spolski et al.   Annual Review of Immunology