Review
Oncology
Mahshid Deldar Abad Paskeh, Maliheh Entezari, Sepideh Mirzaei, Amirhossein Zabolian, Hossein Saleki, Mohamad Javad Naghdi, Sina Sabet, Mohammad Amin Khoshbakht, Mehrdad Hashemi, Kiavash Hushmandi, Gautam Sethi, Ali Zarrabi, Alan Prem Kumar, Shing Cheng Tan, Marios Papadakis, Athanasios Alexiou, Md Asiful Islam, Ebrahim Mostafavi, Milad Ashrafizadeh
Summary: This review discusses the role of exosomes in cancer progression, therapy, and regulation of the tumor microenvironment. The study found that exosomes can influence cancer cell proliferation and migration rates by modulating components of the tumor microenvironment. Depending on their cargo, exosomes can promote or suppress tumor cell progression and enhance or reduce the response to radiotherapy and chemotherapy. Additionally, exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by transferring RNA and modulating molecular signaling pathways. Moreover, exosomes can serve as carriers of anti-tumor agents and genetic tools to control cancer progression. Finally, exosomes are valuable diagnostic and prognostic tools in the treatment of cancer patients.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Bing-Jie Tang, Bao Sun, Lei Chen, Jie Xiao, Shu-Ting Huang, Ping Xu
Summary: This review outlines the important role of exosomal non-coding RNAs in leukemia and discusses their potential as therapeutic targets and biomarkers. The prospects and challenges for exosomal non-coding RNAs in research and clinical applications are also analyzed.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Maoye Wang, Jianmei Gu, Xu Zhang, Jianping Yang, Xiaoxin Zhang, Xinjian Fang
Summary: DANCR, a cancer-associated lncRNA, is abnormally expressed in various cancers and affects cancer cell proliferation, migration, and chemoresistance through multiple mechanisms. It can be detected in body fluids and has potential as a diagnostic and prognostic biomarker and therapeutic target for cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Yuanyuan Yang, Lintao Miao, Yuchao Lu, Yi Sun, Shaogang Wang
Summary: Exosomes play important roles in the development, diagnosis, and drug delivery of bladder cancer. Engineering exosomes can enhance their potential for bladder cancer treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Oncology
Shenqi Han, Yongqiang Qi, Yiming Luo, Xiaoping Chen, Huifang Liang
Summary: Exosomal lncRNAs, derived from both cancer cells and stromal cells, play a crucial role in promoting cancer progression by regulating gene expression and mediating the formation of pre-metastatic niches. Understanding the functions of exosomal lncRNAs in cancer development will provide valuable insights for cancer treatment strategies.
FRONTIERS IN ONCOLOGY
(2021)
Review
Genetics & Heredity
Liqiao Chen, Jingyu Deng
Summary: Noncoding RNAs play important roles in regulating the immune microenvironment of gastric cancer, with potential implications for improving patient prognosis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Cardiac & Cardiovascular Systems
Yuyan Tang, Huaping Li, Chen Chen
Summary: Atherosclerosis is a chronic inflammatory disease that is the main cause of disability and mortality worldwide. Non-coding RNAs have been found to play a crucial role in its development and regulation of cellular processes. They have the potential to be therapeutic targets and have been used in designing new drugs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Mu Liu, Xiaofang Zhou, Jie Tang
Summary: sEVs-ncRNAs play important roles in the development and treatment of ovarian cancer, serving as biomarkers for diagnosis and prognosis by regulating cell signaling and revealing the status of parental cells. Studying the biological roles of sEVs-ncRNAs contributes to the discovery of new therapeutic targets and innovative treatment strategies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cell Biology
Nasrin Ahangar Davoodi, Sajad Najafi, Zari Naderi Ghale-Noie, Ashkan Piranviseh, Samaneh Mollazadeh, Sahar Ahmadi Asouri, Zatollah Asemi, Mohammadamin Morshedi, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Amirhossein Sheida, Hamed Mirzaei
Summary: Retinoblastoma (RB) is a rare aggressive intraocular malignancy of childhood that can have severe consequences. Non-coding RNAs (ncRNAs) play important roles in the pathogenesis and development of RB, with different ncRNAs acting as either tumor promoters or suppressors. Understanding the regulatory mechanisms of ncRNAs provides new opportunities for RB therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Hui-Jin Li, Xue Gong, Zheng-Kun Li, Wei Qin, Chun-Xia He, Lu Xing, Xin Zhou, Dong Zhao, Hui-Ling Cao
Summary: Bladder cancer is characterized by dysregulated lncRNAs, which play key roles in tumorigenesis, progression, and prognosis. These lncRNAs can serve as potential diagnostic and prognostic biomarkers for bladder cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xiaoqi Yang, Tao Ye, Haoran Liu, Peng Lv, Chen Duan, Xiaoliang Wu, Kehua Jiang, Hongyan Lu, Ding Xia, Ejun Peng, Zhiqiang Chen, Kun Tang, Zhangqun Ye
Summary: circRNAs play crucial regulatory roles in BCa by modulating various biological behaviors through miRNA sponging mechanisms. The expression levels of circRNAs are significantly associated with clinicopathologic characteristics and can be used to predict patient survival parameters. Due to their abundance, conservation, stability, specificity, and detectability, circRNAs are considered potential diagnostic and prognostic biomarkers for BCa.
Review
Oncology
Moritz Reese, Sameer A. Dhayat
Summary: Pancreatic cancer has a poor prognosis due to its aggressive nature, late diagnosis, and resistance to treatment. Non-coding RNAs distributed through sEVs in the tumor microenvironment play a crucial role in intercellular communication and can serve as potential biomarkers and delivery vehicles for cancer therapy.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Hongxu Li, Jie Gao, Long Liu, Shuijun Zhang
Summary: LINC00958, a long non-coding RNA highly expressed in various malignancies, plays a role in enhancing tumor cells' resistance to radiotherapy and chemotherapy, inducing lymphangiogenesis, and facilitating tumor glycolytic metabolism. Additionally, LINC00958 acts as a ceRNA and regulates the malignant behavior of tumor cells through the miRNA-mRNA axis, showcasing potential as a novel biomarker and therapeutic target in cancer diagnosis and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Hao Gengna, Qingchen Zhouna, Wenhao Guo, Ling Lu, Liangkuan Bi, Yi Wang, Jie Min, Dexin Yu, Zhaofeng Liang
Summary: Exosomes are nanometer-sized vesicles containing various biologically active components, which have great potential as biomarkers for bladder cancer (BC) due to their high abundance and stability in body fluids.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Review
Oncology
Sajad Najafi, Seyyed Hossein Khatami, Marjan Khorsand, Zeinab Jamali, Zahra Shabaninejad, Mostafa Moazamfard, Jamal Majidpoor, Seyed Mohsen Aghaei Zarch, Ahmad Movahedpour
Summary: New research has shown that long non-coding RNAs (lncRNAs) play crucial roles in various biological processes, including the development of complex human diseases like cancer. Although the specific regulation mechanisms of many lncRNAs in cancer are still unknown, a few have been identified. This study provides a summary of recent advances in understanding the mechanisms and functions of lncRNAs in cancer, with a focus on their roles as oncogenes and tumor suppressors, as well as their potential use as biomarkers for cancer diagnosis and prognosis.
EXPERIMENTAL CELL RESEARCH
(2022)