Review
Biochemistry & Molecular Biology
Atsuki Suzuki, Yasuomi Urano, Tomohisa Ishida, Noriko Noguchi
Summary: 24S-OHC and 25OHC induced the same type of cell death in each of the cell types examined, and the inhibitory effect varied depending on the type of cell death for alpha-Toc and alpha-Toc3.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Plant Sciences
Jing Zhao, Kaixin Ding, Manting Hou, Yuanhua Li, Xiaorong Hou, Wenzhang Dai, Zhiyong Li, Jun Zhao, Wenlong Liu, Zhaofang Bai
Summary: This study demonstrated that Schisandra chinensis essential oil has protective effects against acetaminophen-induced liver injury in mice, suggesting its potential as a therapeutic option for liver diseases.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Plant Sciences
Yunfeng Zhou, Chunli Wang, Jiejian Kou, Minghui Wang, Xuli Rong, Xiaohui Pu, Xinmei Xie, Guang Han, Xiaobin Pang
Summary: This study demonstrated that Bianliang ziyu flower ethanol extract protected rats from APAP-induced liver injury through antioxidant and anti-apoptotic pathways, suggesting its potential as a liver-protecting agent. Network pharmacology predicted potential pathways of BZE, showing its liver-protective effect was associated with antioxidant and anti-apoptotic efficacy.
PHARMACEUTICAL BIOLOGY
(2021)
Review
Neurosciences
Genea Edwards, Caroline G. Olson, Carlyn P. Euritt, Peter Koulen
Summary: The eye is sensitive to oxidative stress, and vitamin E plays a crucial role in protecting against degenerative diseases. Vitamin E has diverse antioxidant activity and can promote neuroprotective effects through several signaling pathways. Further research is needed to fully understand its clinical implications.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Meng Li, Qiong Luo, Yanyan Tao, Xin Sun, Chenghai Liu
Summary: This article reviews the accumulated literature on drug-induced liver injury (DILI) with evidence-based medicine researches and discusses the limitations of clinical studies and the prospective development for DILI therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sabine Weber, Alexander L. Gerbes
Summary: Drug-induced liver injury (DILI) is a rare but potentially severe adverse drug event, which poses a major challenge for diagnosis in clinical practice and pharmacovigilance. Efforts have been made to establish diagnostic testing methods and biomarkers for safe diagnosis and differentiation from other liver diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Gastroenterology & Hepatology
Steven Trinh, Nicholas Batt, Rohit Sawhney, Amanda Nicoll
Summary: Drug-induced liver injury (DILI) is a rare cause of acute liver injury. Bjornsson et al. establish a European DILI registry to assess the clinical features and outcomes of DILI in several European countries. The authors highlight the need for reporting potential outcomes from pharmacotherapy to determine the role of medical therapy for DILI, as this information is currently lacking.
LIVER INTERNATIONAL
(2023)
Article
Food Science & Technology
Aleksander Siger, Pawel Gornas
Summary: The tocopherol and tocotrienol profiles were studied in 418 plant oil samples, representing 31 families, 82 species, and 5 cross-species. Tocotrienols dominated in 15 species, while tocopherols dominated in 67 species. Gamma-T accounted for almost half (49.3%) of the total tocochromanol content, while alpha-T constituted one quarter (25.0%), and other tocochromanols were minor constituents. The presence of characteristic tocochromanol profiles in oils was related to the taxonomic plant origin. This study also demonstrated that both monocotyledonous and dicotyledonous families can be rich in tocotrienols. The usefulness of statistical tools such as PCA and HCA for differentiating plant samples based on their tocochromanol profile was shown.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Zhimin Wu, Yazhi Li, Huajiao Qiu, Songhua Long, Xinlin Zhao, Yufu Wang, Xinbo Guo, Aliya Baitelenova, Caisheng Qiu
Summary: This study aimed to investigate the relationship between different flaxseed varieties, their agronomic traits, and seed quality. The study found that fiber flax variety had the highest lignan content, while oil flax variety had the highest levels of vitamins and carotenoids. The study also observed correlations between seed yield, seed type, plant height, and fiber content with seed quality.
Article
Pharmacology & Pharmacy
Mohd Saufi Harun, Tin Wui Wong, Chee Wai Fong
Summary: The study investigated a combination of nanocarrier and microwave system for delivering alpha-tocopherol and gamma-tocotrienol against dermatitis without the thinning effect of steroids. By formulating vitamin E into water-rich/water-poor nanoemulsions and pre-treating the skin with precision microwave, the research found that the approach promoted therapeutic accumulation in the skin epidermis, leading to an alleviation of dermatitis without the skin thinning effect. The combination of microwave and nanotechnology offers a promising strategy for enhancing vitamin delivery and improving dermatitis treatment outcomes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Gastroenterology & Hepatology
Katerina Roma, Salman Mohammed, Blake Sieck, Katrina Naik, Shahid Wahid
Summary: Alternative medicine supplements, such as kratoms, have become a significant cause of liver injury in the US. Reports of adverse events linked to kratom use are increasing, including liver injury, organ dysfunction, and even death. The need for increased regulation and public awareness of the risks associated with kratom is emphasized.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yi-Shin Huang, Ting-Tsung Chang, Cheng-Yuan Peng, Gin-Ho Lo, Chao-Wei Hsu, Chi-Tan Hu, Yi-Hsiang Huang
Summary: The study found that herbal and dietary supplements accounted for more than one-fifth of drug-induced liver injuries in Taiwan, and patients with HILI were more severe and had a higher mortality rate compared to those with CILI. Hepatitis B carriers, individuals with elevated baseline liver tests, and users of crude herbs may face a higher risk of HILI-related mortality. Prudent use of HDS is recommended for these high-risk individuals.
HEPATOLOGY INTERNATIONAL
(2021)
Review
Pharmacology & Pharmacy
Xinghui Li, Jiaqi Ni, Li Chen
Summary: This review focuses on the diagnosis, screening, and management of Acetaminophen (APAP)-induced liver injury (AILI), which is a significant cause of drug-induced liver injury and acute liver failure. It summarizes recent research progress, highlights current issues, and provides recommendations for future research.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Estanislao Burgos, Maria Belen De Luca, Isidore Diouf, Luis A. de Haro, Elise Albert, Christopher Sauvage, Zhao J. Tao, Luisa Bermudez, Ramon Asis, Adriano N. Nesi, Michel Matringe, Claire Brehelin, Thomas Guiraud, Carine Ferrand, Isabelle Atienza, Joana Jorly, Jean P. Mauxion, Pierre Baldet, Alisdair R. Fernie, Leandro Quadrana, Christophe Rothan, Mathilde Causse, Fernando Carrari
Summary: By studying the genetic determinants of tocochromanol accumulation in tomato fruits and genetically engineering their biosynthetic pathway, a total of 25 quantitative trait loci were identified across the genome. By bypassing specific pathway points, the engineered tomatoes showed increased tocopherols and tocotrienols content, indicating a trade-off between VTE and natural variation in chorismate metabolism.
Article
Toxicology
Guillermo Quintas, Teresa Martinez-Sena, Isabel Conde, Eugenia Pareja Ibars, Jos Kleinjans, Jose Castell
Summary: DILI, an adverse toxic reaction associated with drug administration, is currently classified based on ALT and ALP values, but lacks accuracy. By integrating metabolomic information, a more accurate evaluation of DILI phenotypes can be achieved.
ARCHIVES OF TOXICOLOGY
(2021)