Review
Immunology
Guoxu Zheng, Lintao Jia, An-Gang Yang
Summary: HLA-G/KIR2DL4 plays an important role in breast cancer, serving as a key factor in drug resistance and immune evasion. Research on HLA-G is beneficial for identifying new biomarkers for breast cancer, improving the accuracy of diagnosis and prognostic assessment. Additionally, unraveling the mechanisms underlying HLA-G/KIR2DL4 regulation of the immune microenvironment in breast cancer provides a theoretical basis for combined HLA-G and immune checkpoint targeting.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Peilong Li, Nan Wang, Yi Zhang, Chuanxin Wang, Lutao Du
Summary: HLA-G, a non-classic MHC class I molecule, is widely expressed in tumor environment where it plays a key role in immune escape, potentially important for cancer diagnosis and prognosis. However, due to its multiple subtypes, evaluating HLA-G expression in tumors is challenging.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Pei-Yu Chen, Wen-Fei Wei, Hong-Zhen Wu, Liang-Sheng Fan, Wei Wang
Summary: CAFs are important and heterogeneous components of the tumor extracellular matrix, with different origins and biomarkers, playing a role in immune regulation of the tumor microenvironment and exerting immunosuppressive functions through various mechanisms. Inhibition of CAFs and targeted therapy against CAFs offer new adjuvant means for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Marco Fangazio, Erik Ladewig, Karen Gomez, Laura Garcia-Ibanez, Rahul Kumar, Julie Teruya-Feldstein, Davide Rossi, Ioan Filip, Qiang Pan-Hammarstrom, Giorgio Inghirami, Renzo Boldorini, German Ott, Annette M. Staiger, Bjorn Chapuy, Gianluca Gaidano, Govind Bhagat, Katia Basso, Raul Rabadan, Laura Pasqualucci, Riccardo Dalla-Favera
Summary: The loss of MHC-I in DLBCL is associated with somatic inactivation of HLA-I loci and has a significant impact on neoantigen and mutational burden. There is a multistep process of HLA-I loss in DLBCL development involving both germline and somatic events.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Simon Jasinski-Bergner, Markus Eckstein, Helge Taubert, Sven Wach, Christian Fiebig, Reiner Strick, Arndt Hartmann, Barbara Seliger
Summary: The non-classical human leukocyte antigen G (HLA-G) is a regulatory protein that plays a significant role in inducing immunological tolerance by inhibiting the functions of immune effector cells. HLA-G expression has been observed in urological cancers and is associated with tumor progression and poor patient outcomes. It protects tumor cells from anti-tumor immunity and modulates immune cell phenotype and function, allowing immune evasion.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alessandro Giammona, Enrica Crivaro, Barbara Stecca
Summary: Hedgehog-GLI signaling is important in embryogenesis and tissue homeostasis and its aberrant activation is involved in various cancers. Targeted inhibition of the pathway is a potential treatment strategy. Recent studies have also shown its role in tumor immune evasion and poor responses to cancer immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Nelson K. Y. Wong, Xin Dong, Yen-Yi Lin, Hui Xue, Rebecca Wu, Dong Lin, Colin Collins, Yuzhuo Wang
Summary: Androgen deprivation therapy is the standard treatment for advanced prostate cancer, but most patients eventually relapse. The study of the dormant phase of prostate cancer progression is hindered by limited clinical tissue and preclinical models. This study uses unique patient-derived xenograft models to investigate the immune evasion mechanisms of dormant prostate cancer cells, providing a framework for further research and immune-based therapies.
Review
Biochemistry & Molecular Biology
Nils Kosiol, Stefan Juranek, Peter Brossart, Annkristin Heine, Katrin Paeschke
Summary: The importance of G4 structures in malignant cell characterization has been demonstrated, potentially enabling stratified treatment of breast cancer. G4 structures serve as therapeutic targets, with the development of targeted chemical molecules to disrupt cancer cell function.
Review
Oncology
Zhou Chen, Xiaodong Wei, Shi Dong, Fangfang Han, Ru He, Wence Zhou
Summary: This narrative review summarizes the current evidence on the impact of platelets on pancreatic cancer, including their role in cancer promotion, drug resistance mechanisms, and potential therapeutic approaches. A refined understanding of the role of platelets provides the basis for identifying new treatment targets for pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Jose Manuel Martin-Villa, Christian Vaquero-Yuste, Marta Molina-Alejandre, Ignacio Juarez, Fabio Suarez-Trujillo, Adrian Lopez-Nares, Jose Palacio-Gruber, Luis Barrera-Gutierrez, Eduardo Fernandez-Cruz, Carmen Rodriguez-Sainz, Antonio Arnaiz-Villena
Summary: HLA-G is a non-classical HLA class I molecule with immunomodulatory properties that is involved in various processes such as organ transplantation, viral infections, cancer progression, and autoimmune diseases. Its immunosuppressive effect is exerted through interaction with its receptors on immune cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Simon Jasinski-Bergner, Dominik Schmiedel, Ofer Mandelboim, Barbara Seliger
Summary: This review provides a summary of the expression, regulation, function, and impact of HLA-G in the context of different viral infections, including virus-associated cancers. It emphasizes the potential use of HLA-G as a novel diagnostic and prognostic biomarker for viral infections, as well as a therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Baimei Zhuang, Jin Shang, Yuanqing Yao
Summary: HLA-G plays a crucial role in maternal-fetal immune tolerance, maintaining immune homeostasis and considered a key factor for successful pregnancies. Understanding the characteristics of HLA-G is important for treating pathological pregnancies and other immune-related diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemical Research Methods
Soyeon Kim, YuLong Bai, Zhenjiang Fan, Brenda Diergaarde, George C. Tseng, Hyun Jung Park
Summary: The study utilizes the PRIMATA-APA method to analyze TCGA breast cancer data, revealing that global APA events can alter the number of target sites for specific miRNAs enriched in cancer development and treatment. The knockdown of NUDT21 in HeLa cells shows that APA events can change the target sites of common tamoMiRNAs. The findings suggest that APA-induced tumorigenesis is attributed to changes in miRNA target sites rather than the APA events themselves.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Medicine, Research & Experimental
Yan Chen, Xiaozhen Zhang, Hanshen Yang, Tingbo Liang, Xueli Bai
Summary: Autophagy plays a role in maintaining cellular energy balance and protecting cells from stress by removing damaged components. In the tumor microenvironment, cancer-associated fibroblasts (CAFs) have a dual effect on tumor development, with autophagy inhibiting tumor growth in early stages but promoting it in advanced stages.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Jun Gan, Xing-Hong Di, Zi-Yi Yan, Yang-Fan Gao, Hui-Hui Xu
Summary: This study found that HLA-G 3'UTR polymorphisms may influence the peripheral sHLA-G plasma level in patients and play a key role in the susceptibility and prognosis of cervical cancer. sHLA-G may represent a novel plasma biomarker for the prognosis and potential therapeutic target of cervical cancer.
FRONTIERS IN IMMUNOLOGY
(2022)