Energy Demands of Early Life Drive a Disease Tolerant Phenotype and Dictate Outcome in Neonatal Bacterial Sepsis

Why are preterm newborns at increased risk of infection?

(2018) Amélie Collins et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Endotype Transitions During the Acute Phase of Pediatric Septic Shock Reflect Changing Risk and Treatment Response

(2018) Hector R. Wong et al.   CRITICAL CARE MEDICINE

Dietary Fiber Confers Protection against Flu by Shaping Ly6c − Patrolling Monocyte Hematopoiesis and CD8 + T Cell Metabolism

(2018) Aurélien Trompette et al.   IMMUNITY

Targeting macrophage immunometabolism: Dawn in the darkness of sepsis

(2018) V. Kumar   INTERNATIONAL IMMUNOPHARMACOLOGY

Mechanisms and treatment of organ failure in sepsis

(2018) Christophe Lelubre et al.   Nature Reviews Nephrology

The global burden of paediatric and neonatal sepsis: a systematic review

(2018) Carolin Fleischmann-Struzek et al.   Lancet Respiratory Medicine

Outgrowing the Immaturity Myth: The Cost of Defending From Neonatal Infectious Disease

(2018) Danny Harbeson et al.   Frontiers in Immunology

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

(2017) Gökhan S. Hotamisligil   IMMUNITY

Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny

(2017) Tobias R. Kollmann et al.   IMMUNITY

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Metabolic regulation of inflammation

(2017) Timo Gaber et al.   Nature Reviews Rheumatology

Newborn susceptibility to infection vs. disease depends on complex in vivo interactions of host and pathogen

(2017) Byron Brook et al.   Seminars in Immunopathology

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study

(2017) Brendon P Scicluna et al.   Lancet Respiratory Medicine

Application of LC-MS-based metabolomics method in differentiating septic survivors from non-survivors

(2016) Zhicheng Liu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation

(2016) Andrew Wang et al.   CELL

Anti-inflammatory effects of omega 3 and omega 6 polyunsaturated fatty acids in cardiovascular disease and metabolic syndrome

(2016) Esther Tortosa-Caparrós et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Enterovirus infection in febrile neonates: A hospital-based prospective cohort study

(2016) Xiao-Qing Lv et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

β-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms

(2016) Lavanya B. Achanta et al.   NEUROCHEMICAL RESEARCH

Immunometabolic circuits in trained immunity

(2016) Rob J.W. Arts et al.   SEMINARS IN IMMUNOLOGY

Immunometabolic Pathways in BCG-Induced Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Reports

Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

(2016) Gianpaolo Rando et al.   eLife

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study

(2016) Emma E Davenport et al.   Lancet Respiratory Medicine

Human Monocytes Undergo Functional Re-programming during Sepsis Mediated by Hypoxia-Inducible Factor-1α

(2015) Irina N. Shalova et al.   IMMUNITY

Immunometabolism: Cellular Metabolism Turns Immune Regulator

(2015) Róisín M. Loftus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glucose metabolism and astrocyte–neuron interactions in the neonatal brain

(2015) Eva Brekke et al.   NEUROCHEMISTRY INTERNATIONAL

Population-based Incidence and Etiology of Community-acquired Neonatal Viral Infections in Bangladesh

(2015) Azadeh Farzin et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

The infant microbiome development: mom matters

(2015) Noel T. Mueller et al.   TRENDS IN MOLECULAR MEDICINE

The Human Neonatal Gut Microbiome: A Brief Review

(2015) Emily C. Gritz et al.   Frontiers in Pediatrics

Energy crisis: The role of oxidative phosphorylation in acute inflammation and sepsis

(2014) Icksoo Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Urinary 1H-NMR and GC-MS metabolomics predicts early and late onset neonatal sepsis

(2014) Vassilios Fanos et al.   EARLY HUMAN DEVELOPMENT

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Estimates of possible severe bacterial infection in neonates in sub-Saharan Africa, south Asia, and Latin America for 2012: a systematic review and meta-analysis

(2014) Anna C Seale et al.   LANCET INFECTIOUS DISEASES

Herpes simplex virus serotype and entry receptor availability alter CNS disease in a mouse model of neonatal HSV

(2014) Sarah J. Kopp et al.   PEDIATRIC RESEARCH

Myeloid Derived Suppressor Cells Are Present at High Frequency in Neonates and Suppress In Vitro T Cell Responses

(2014) Ana Gervassi et al.   PLoS One

Identification of a human neonatal immune-metabolic network associated with bacterial infection

(2014) Claire L. Smith et al.   Nature Communications

UNICEF Report: enormous progress in child survival but greater focus on newborns urgently needed

(2014) Tessa Wardlaw et al.   Reproductive Health

Oxygen therapy for sepsis patients in the emergency department

(2013) Renate Stolmeijer et al.   European Journal of Emergency Medicine

Inhibition of rotavirus replication by downregulation of fatty acid synthesis

(2013) E. R. Gaunt et al.   JOURNAL OF GENERAL VIROLOGY

The manner of the inflammation-boosting effect caused by acute hyperglycemia secondary to overfeeding and the effects of insulin therapy in a rat model of sepsis

(2013) Satoshi Yoneyama et al.   JOURNAL OF SURGICAL RESEARCH

Polymicrobial sepsis is associated with decreased hepatic oxidative phosphorylation and an altered metabolic profile

(2013) Sean P. Whelan et al.   JOURNAL OF SURGICAL RESEARCH

An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis

(2013) R. J. Langley et al.   Science Translational Medicine

Ketone bodies as signaling metabolites

(2013) John C. Newman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Energy expenditure of critically ill neonatal foals

(2012) E. JOSE-CUNILLERAS et al.   EQUINE VETERINARY JOURNAL

Variation in Fat, Lactose, and Protein Composition in Breast Milk over 24 Hours

(2012) Sadaf Khan et al.   JOURNAL OF HUMAN LACTATION

Targeted metabolomics for discrimination of systemic inflammatory disorders in critically ill patients

(2012) Diana Schmerler et al.   JOURNAL OF LIPID RESEARCH

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

AMP-Activated Kinase Restricts Rift Valley Fever Virus Infection by Inhibiting Fatty Acid Synthesis

(2012) Theresa S. Moser et al.   PLoS Pathogens

Quantitative Membrane Protein Expression at the Blood–Brain Barrier of Adult and Younger Cynomolgus Monkeys

(2011) Katsuaki Ito et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Challenges in infant immunity: implications for responses to infection and vaccines

(2011) Mercy PrabhuDas et al.   NATURE IMMUNOLOGY

Viral effects on metabolism: changes in glucose and glutamine utilization during human cytomegalovirus infection

(2011) Yongjun Yu et al.   TRENDS IN MICROBIOLOGY

The use of a neonatal mouse model to study respiratory syncytial virus infections

(2010) Stephania A Cormier et al.   Expert Review of Anti-Infective Therapy

Rest energy expenditure is decreased during the acute as compared to the recovery phase of sepsis in newborns

(2010) Rubens Feferbaum et al.   Nutrition & Metabolism

The Physiologic Response and Associated Clinical Benefits From Provision of Early Enteral Nutrition

(2009) Stephen A. McClave et al.   NUTRITION IN CLINICAL PRACTICE

Cellular energetic metabolism in sepsis: The need for a systems approach

(2008) Jane E. Carré et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists

(2008) J. L. Wynn et al.   BLOOD

Potential of immunomodulatory agents for prevention and treatment of neonatal sepsis

(2008) J L Wynn et al.   Journal of Perinatology

Hyper innate responses in neonates lead to increased morbidity and mortality after infection

(2008) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA