Review
Plant Sciences
Zubair Ahmed Ratan, Soo Hyun Youn, Yi-Seong Kwak, Chang-Kyun Han, Mohammad Faisal Haidere, Jin Kyeong Kim, Hyeyoung Min, You-Jung Jung, Hassan Hosseinzadeh, Sun Hee Hyun, Jae Youl Cho
Summary: Traditional medicinal practices have utilized natural products such as Panax ginseng to treat various diseases, with numerous studies indicating its potential in modulating the immune system. Further research is needed to explore the full scope of ginseng's effectiveness in disease prevention and treatment.
JOURNAL OF GINSENG RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Jacqueline Alves Leite, Luiz Henrique Agra Cavalcante-Silva, Martina Raissa Ribeiro, Geovanni de Morais Lima, Cristoforo Scavone, Sandra Rodrigues-Mascarenhas
Summary: This review examines the potential regulatory role of the cardiac steroid ouabain in neutrophilic neuroinflammation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Iwona T. Myszor, Gudmundur Hrafn Gudmundsson
Summary: The innate immune system of the airway epithelium consists of multiple components that work together to protect the host from invading pathogens. Modulating innate immune responses in the airway epithelium to boost host defenses and enhance immune responses is an alternative approach to standard antibiotics. This review discusses the possibilities of such modulation for host-directed therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Elisa Jentho, Cristian Ruiz-Moreno, Boris Novakovic, Ioannis Kourtzelis, Wout L. Megchelenbrink, Rui Martins, Triantafyllos Chavakis, Miguel P. Soares, Lydia Kalafati, Joel Guerra, Franziska Roestel, Peter Bohm, Maren Godmann, Tatyana Grinenko, Anne Eugster, Martina Beretta, Leo A. B. Joosten, Mihai G. Netea, Michael Bauer, Hendrik G. Stunnenberg, Sebastian Weis
Summary: Trained immunity refers to long-lasting adaptations of innate immunity, and labile heme has been identified as a previously unrecognized inducer of trained immunity. Unlike other inducers that rely on pathogen-associated molecular patterns, heme training activates a unique signaling pathway and is associated with the expansion of self-renewing hematopoetic stem cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Masaaki Higashiyama, Soichiro Miura, Ryota Hokari
Summary: Luminal factors such as antigens, nutrients, and metabolites from bacteria, as well as neuropeptides, influence immune cell function and migration in the intestine. Innate lymphoid cells in the gut, including macrophages, neutrophils, dendritic cells, mast cells, and innate lymphoid cells, play a crucial role in maintaining intestinal homeostasis by responding to pathogens in the gut. Dysregulation of these immune cells caused by luminal factors can lead to intestinal disorders like IBD, IBS, and intestinal allergy. Luminal and neural factors not only regulate immune responses in the gut but also modulate the migration of immune cells through the lymphatic system.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Aminata P. Coulibaly
Summary: Behavior and cognition are influenced by genetics, synaptic plasticity, and neuronal connectivity. Peripheral inflammation and immune cells have been shown to play important roles in the preservation and deterioration of behavior and cognition. This review summarizes the current knowledge on the effects of immune cell activation on various behaviors and cognitive processes.
IMMUNOLOGICAL REVIEWS
(2022)
Review
Biotechnology & Applied Microbiology
Chung-Nga Ko, Shaohong Zang, Yingtang Zhou, Zhangfeng Zhong, Chao Yang
Summary: This article provides an up-to-date overview of the strategies and applications of nanocarrier-assisted innate immune modulation for the management of infections and their associated complications. It discusses the importance of innate immunity in defending against pathogens and the role of immunomodulators in treating infectious diseases. The use of nanocarriers as a promising tool to overcome challenges in immunomodulator therapy is also explored.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Immunology
Holly J. Hulsebus, Kevin M. Najarro, Rachel H. McMahan, Devin M. Boe, David J. Orlicky, Elizabeth J. Kovacs
Summary: Alcohol consumption increases the risk of infections, particularly pneumococcal pneumonia. Pneumonia patients with alcohol use require more intensive treatment and longer hospital stays. Alcohol consumption affects the immune response in the respiratory tract.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuo Geng, RuiCi Lin, Yajun Wu, Jing Wang, Liwu Li
Summary: Innate immune cells adopt distinct memory states during the pathogenesis of acute and chronic inflammatory diseases, with reactive oxygen species (ROS) playing key roles in their programming dynamics. ROS modulate the adaptation of innate leukocytes to inflammatory signals and facilitate fundamental processes such as priming, tolerance, and exhaustion. They can be generated at different subcellular compartments and may differentially facilitate innate memory dynamics.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Medicine, General & Internal
Marwan Bouras, Karim Asehnoune, Antoine Roquilly
Summary: Traumatic brain injury (TBI) triggers an immediate immune response in brain tissue, followed by a systemic inflammatory response. This response aims to limit excessive systemic inflammation and promote healing, involving the regulation of the autonomic nervous system, hormonal systems, and immune cells. However, it also leads to immunosuppression and tolerance, which increases the risk of secondary infections.
FRONTIERS IN MEDICINE
(2022)
Editorial Material
Immunology
Xinxin Wang, Yuping Lai
Summary: In this study, the authors investigate the mechanism by which pattern recognition receptors NOD1 and NOD2 sense bacterial muropeptides to induce inflammation in keratinocytes. They demonstrate that solute carrier 46A2 (SLC46A2) transports DAP-muropeptides into the cytosol, leading to NOD1 activation and subsequent skin inflammation during psoriasis.
Article
Nutrition & Dietetics
Banafsheh Hosseini, Bronwyn S. Berthon, Megan E. Jensen, Rebecca F. McLoughlin, Peter A. B. Wark, Kristy Nichol, Evan J. Williams, Katherine J. Baines, Adam Collison, Malcolm R. Starkey, Joerg Mattes, Lisa G. Wood
Summary: This study found that a high F&V diet can reduce the risk of acute exacerbations in children with asthma and improve their cytokine production. Improving diet quality by increasing fruit and vegetable intake may be an effective non-pharmacological strategy for preventing asthma-related illness.
Article
Cell Biology
Lisa Wohlgemuth, Alexander Elias Paul Stratmann, Frederik Muennich, Stefan Bernhard, Bertram Dietrich Thomass, Finn Munnich, Adam Omar Khalaf Mohamed, Marco Mannes, Christoph Quirin Schmidt, Kristina Nilsson Ekdahl, Bo Nilsson, Michael Fauler, Karl Josef Fohr, Markus Huber-Lang, David Alexander Christian Messerer
Summary: The early interactions between neutrophil granulocytes and complement cleavage products play a crucial role in neutrophil activity. While C3a and C4a have no significant effects, C5a and C5a des-Arg stimulate neutrophil activity and alter the expression of various receptors and activation markers.
Review
Cell Biology
Huihai Yang, Lulu Wang, Jing Zhang
Summary: Cancer immunotherapy is an effective strategy for treating cancer, and herbal medicines and natural products play an important role in modulating tumor immunosurveillance.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Chemistry, Organic
Rachid Naitaleb, Agnes Denys, Fabrice Allain, Jerome Ausseil, Sylvestre Toumieux, Jose Kovensky
Summary: The study designed and synthesized sulfated compounds capable of crossing the blood-brain barrier, which were tested on HEK-TLR4 cells, demonstrating the potential of small oligosaccharides to modulate TLR4 activity with the 6-sulfate groups playing a key role in triggering TLR4 signalization.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)