Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy

Protein Replacement Therapy and Gene Transfer in Canine Models of Hemophilia A, Hemophilia B, von Willebrand Disease, and Factor VII Deficiency

(2013) T. C. Nichols et al.   ILAR JOURNAL

Recombinant canine B-domain-deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

(2009) D. E. Sabatino et al.   BLOOD

Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy

(2009) B. Peng et al.   BLOOD

In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance

(2009) A. Annoni et al.   BLOOD

Risk factors for inhibitor formation in haemophilia: a prevalent case-control study

(2009) M. V. RAGNI et al.   HAEMOPHILIA

Co-morbidity in the ageing haemophilia patient: the down side of increased life expectancy

(2009) E. P. MAUSER-BUNSCHOTEN et al.   HAEMOPHILIA

The molecular mechanisms of immunomodulation and tolerance induction to factor VIII

(2009) B. WATERS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Intensive peri-operative use of factor VIII and the Arg593→Cys mutation are risk factors for inhibitor development in mild/moderate hemophilia A

(2009) C.L. ECKHARDT et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Inhibitors of Factor VIII in Black Patients with Hemophilia

(2009) Kevin R. Viel et al.   NEW ENGLAND JOURNAL OF MEDICINE

A novel monoclonal antibody specific for canine CD25 (P4A10): Selection and evaluation of canine Tregs

(2009) V. Kraig Abrams et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Successful treatment of canine hemophilia by continuous expression of canine FVIIa

(2008) P. Margaritis et al.   BLOOD

Treatment of Leber Congenital Amaurosis Due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

(2008) William W. Hauswirth et al.   HUMAN GENE THERAPY

Neutralizing antibodies to therapeutic enzymes: considerations for testing, prevention and treatment

(2008) Jinhai Wang et al.   NATURE BIOTECHNOLOGY

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

(2008) Albert M. Maguire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis

(2008) James W.B. Bainbridge et al.   NEW ENGLAND JOURNAL OF MEDICINE