Understanding MHC Class I Presentation of Viral Antigens by Human Dendritic Cells as a Basis for Rational Design of Therapeutic Vaccines

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses

(2013) G. Nizzoli et al.   BLOOD

Sensing of cell death by myeloid C-type lectin receptors

(2013) David Sancho et al.   CURRENT OPINION IN IMMUNOLOGY

Complement opsonization of HIV-1 results in a different intracellular processing pattern and enhanced MHC class I presentation by dendritic cells

(2013) Veronica Tjomsland et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD8+T-cell effector function and transcriptional regulation during HIV pathogenesis

(2013) Korey R. Demers et al.   IMMUNOLOGICAL REVIEWS

Mobilizing monocytes to cross-present circulating viral antigen in chronic infection

(2013) Adam J. Gehring et al.   JOURNAL OF CLINICAL INVESTIGATION

Similar antigen cross-presentation capacity and phagocytic functions in all freshly isolated human lymphoid organ–resident dendritic cells

(2013) Elodie Segura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+dendritic cells at cross presentation

(2013) Lillian Cohn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting Uptake Receptors on Human Plasmacytoid Dendritic Cells Triggers Antigen Cross-Presentation and Robust Type I IFN Secretion

(2013) J. Tel et al.   JOURNAL OF IMMUNOLOGY

Priming of CD8+ T Cells against Cytomegalovirus-Encoded Antigens Is Dominated by Cross-Presentation

(2013) A. Busche et al.   JOURNAL OF IMMUNOLOGY

Binding of DC-SIGN to the Hemagglutinin of Influenza A Viruses Supports Virus Replication in DC-SIGN Expressing Cells

(2013) Marine L. B. Hillaire et al.   PLoS One

Differential response of BDCA-1+ and BDCA-3+ myeloid dendritic cells to respiratory syncytial virus infection

(2013) Meera R Gupta et al.   RESPIRATORY RESEARCH

The Aryl Hydrocarbon Receptor Antagonist StemRegenin 1 Promotes Human Plasmacytoid and Myeloid Dendritic Cell Development from CD34+ Hematopoietic Progenitor Cells

(2013) Soley Thordardottir et al.   STEM CELLS AND DEVELOPMENT

Type I Interferons as Stimulators of DC-Mediated Cross-Priming: Impact on Anti-Tumor Response

(2013) Giovanna Schiavoni et al.   Frontiers in Immunology

Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy

(2012) L. van de Laar et al.   BLOOD

The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells

(2012) G. Schreibelt et al.   BLOOD

Human plasmacytoid dendritic cells efficiently cross-present exogenous Ags to CD8+ T cells despite lower Ag uptake than myeloid dendritic cell subsets

(2012) J. Tel et al.   BLOOD

Fc  receptor antigen targeting potentiates cross-presentation by human blood and lymphoid tissue BDCA-3+ dendritic cells

(2012) T. W. H. Flinsenberg et al.   BLOOD

Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells

(2012) B. Chatterjee et al.   BLOOD

Harnessing human plasmacytoid dendritic cells as professional APCs

(2012) Jurjen Tel et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

(2012) Muzlifah Haniffa et al.   IMMUNITY

F-Actin Is an Evolutionarily Conserved Damage-Associated Molecular Pattern Recognized by DNGR-1, a Receptor for Dead Cells

(2012) Susan Ahrens et al.   IMMUNITY

The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice

(2012) Santiago Zelenay et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of resident and migratory dendritic cells in human lymph nodes

(2012) Elodie Segura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

(2012) Christian K Holm et al.   NATURE IMMUNOLOGY

Immunoglobulin-like transcript receptors on human dermal CD14+ dendritic cells act as a CD8-antagonist to control cytotoxic T cell priming

(2012) J. Banchereau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons

(2012) Corine St Gelais et al.   Retrovirology

Influenza A Virus Infection of Human Primary Dendritic Cells Impairs Their Ability to Cross-Present Antigen to CD8 T Cells

(2012) Anna Smed-Sörensen et al.   PLoS Pathogens

Antigen Processing and Remodeling of the Endosomal Pathway: Requirements for Antigen Cross-Presentation

(2012) Ewoud Bernardus Compeer et al.   Frontiers in Immunology

Into the Intracellular Logistics of Cross-Presentation

(2012) Jacques Neefjes et al.   Frontiers in Immunology

The Role of Heat Shock Proteins in Antigen Cross Presentation

(2012) Ayesha Murshid et al.   Frontiers in Immunology

The Role of XCR1 and its Ligand XCL1 in Antigen Cross-Presentation by Murine and Human Dendritic Cells

(2012) Richard A. Kroczek et al.   Frontiers in Immunology

Expression of XCR1 Characterizes the Batf3-Dependent Lineage of Dendritic Cells Capable of Antigen Cross-Presentation

(2012) Annabell Bachem et al.   Frontiers in Immunology

Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation

(2011) P. J. Tacken et al.   BLOOD

IFN-  enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing

(2011) F. Spadaro et al.   BLOOD

DEC-205 mediates antigen uptake and presentation by both resting and activated human plasmacytoid dendritic cells

(2011) Jurjen Tel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4+ T cells but are incapable of cross-presentation

(2011) Michiel van der Vlist et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Dendritic Cell Subsets from Spleen and Blood Are Similar in Phenotype and Function but Modified by Donor Health Status

(2011) D. Mittag et al.   JOURNAL OF IMMUNOLOGY

Hepatitis B Virus Lacks Immune Activating Capacity, but Actively Inhibits Plasmacytoid Dendritic Cell Function

(2011) Andrea M. Woltman et al.   PLoS One

Mannose receptor polyubiquitination regulates endosomal recruitment of p97 and cytosolic antigen translocation for cross-presentation

(2011) M. Zehner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Modular and Combinatorial View of the Antigen Cross-Presentation Pathway in Dendritic Cells

(2011) Elodie Segura et al.   TRAFFIC

Immunotherapy for persistent viral infections and associated disease

(2011) Sjoerd H. van der Burg et al.   TRENDS IN IMMUNOLOGY

Desirable cell death during anticancer chemotherapy

(2010) Clara Locher et al.   Annals of the New York Academy of Sciences

Evidence of dysregulation of dendritic cells in primary HIV infection

(2010) R. L. Sabado et al.   BLOOD

Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR

(2010) E. Klechevsky et al.   BLOOD

‘Dressed for success’ C-type lectin receptors for the delivery of glyco-vaccines to dendritic cells

(2010) Wendy WJ Unger et al.   CURRENT OPINION IN IMMUNOLOGY

The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8α+dendritic cells

(2010) Karine Crozat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+cells as homologues of mouse CD8+dendritic cells

(2010) Annabell Bachem et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mouse CD8α+DCs and human BDCA3+DCs are major producers of IFN-λ in response to poly IC

(2010) Henning Lauterbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines

(2010) Adam J. Gehring et al.   JOURNAL OF HEPATOLOGY

A look behind closed doors: interaction of persistent viruses with dendritic cells

(2010) Mélanie Lambotin et al.   NATURE REVIEWS MICROBIOLOGY

Cross-Presentation of a Spread-Defective MCMV Is Sufficient to Prime the Majority of Virus-Specific CD8+ T Cells

(2010) Christopher M. Snyder et al.   PLoS One

Transduction of Human T Cells with a Novel T-Cell Receptor Confers Anti-HCV Reactivity

(2010) Yi Zhang et al.   PLoS Pathogens

Long-lasting cross-presentation of tumor antigen in human DC

(2009) Florence Faure et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic cells in chronic viral hepatitis B and C: victims or guardian angels?

(2009) A M Woltman et al.   GUT

The Small GTPase Rac2 Controls Phagosomal Alkalinization and Antigen Crosspresentation Selectively in CD8+ Dendritic Cells

(2009) Ariel Savina et al.   IMMUNITY

MHC Class I/Peptide Transfer between Dendritic Cells Overcomes Poor Cross-Presentation by Monocyte-Derived APCs That Engulf Dying Cells

(2009) C. Qu et al.   JOURNAL OF IMMUNOLOGY

Influenza Virus and Poly(I:C) Inhibit MHC Class I-Restricted Presentation of Cell-Associated Antigens Derived from Infected Dead Cells Captured by Human Dendritic Cells

(2009) D. Frleta et al.   JOURNAL OF IMMUNOLOGY

Presentation of human T cell leukemia virus type 1 (HTLV-1) Tax protein by dendritic cells: the underlying mechanism of HTLV-1-associated neuroinflammatory disease

(2009) Sharrón L. Manuel et al.   JOURNAL OF LEUKOCYTE BIOLOGY

DC-SIGN Mediates Cell-Free Infection and Transmission of Human T-Cell Lymphotropic Virus Type 1 by Dendritic Cells

(2009) P. Jain et al.   JOURNAL OF VIROLOGY

Plasmacytoid Dendritic Cells Capture and Cross-Present Viral Antigens from Influenza-Virus Exposed Cells

(2009) Gabrielle Lui et al.   PLoS One

Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity

(2009) N. van Montfoort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells

(2009) Marjoleine L. Op den Brouw et al.   VIROLOGY

Cellular distribution of the C-type II lectin dendritic cell immunoreceptor (DCIR) and its expression in the rheumatic joint: identification of a subpopulation of DCIR+ T cells

(2008) C Eklow et al.   ANNALS OF THE RHEUMATIC DISEASES

The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis-infection pathways

(2008) A. A. Lambert et al.   BLOOD

Endocytosis mechanisms and the cell biology of antigen presentation

(2008) Sven Burgdorf et al.   CURRENT OPINION IN IMMUNOLOGY

Hepatitis C virus–infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells

(2008) Takashi Ebihara et al.   HEPATOLOGY

Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells

(2008) Eynav Klechevsky et al.   IMMUNITY

Inflammatory signals in dendritic cell activation and the induction of adaptive immunity

(2008) Olivier Joffre et al.   IMMUNOLOGICAL REVIEWS

CLEC9A Is a Novel Activation C-type Lectin-like Receptor Expressed on BDCA3+Dendritic Cells and a Subset of Monocytes

(2008) Cristal Huysamen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dendritic cells mediate herpes simplex virus infection and transmission through the C-type lectin DC-SIGN

(2008) M. A. W. P. de Jong et al.   JOURNAL OF GENERAL VIROLOGY

Modulation of dendritic cell function by persistent viruses

(2008) B. Liu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Scavenger Receptor Class B Is Required for Hepatitis C Virus Uptake and Cross-Presentation by Human Dendritic Cells

(2008) H. Barth et al.   JOURNAL OF VIROLOGY

Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I

(2008) Tiziana Di Pucchio et al.   NATURE IMMUNOLOGY

Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation

(2008) Sven Burgdorf et al.   NATURE IMMUNOLOGY

Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4+ T cells

(2008) Kathryn S Jones et al.   NATURE MEDICINE

Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling

(2008) Scott H Robbins et al.   GENOME BIOLOGY

Binding of human papilloma virus L1 virus-like particles to dendritic cells is mediated through heparan sulfates and induces immune activation

(2007) Lot de Witte et al.   IMMUNOBIOLOGY