Review
Immunology
Jamie A. Sugrue, Nollaig M. Bourke, Cliona O'Farrelly
Summary: Type I interferons and their receptor are crucial components of the innate immune system, with roles in protection against infection and shaping disease pathogenesis. The study of IFN-I has often been oversimplified into a beneficial or pathogenic dichotomy, neglecting more nuanced interpretations. Genetic associations and shared transcriptomic signatures suggest a complex relationship between IFN-I, viral resistance, and susceptibility to autoimmunity, particularly in females.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Rheumatology
Ana Carolina Londe, Ruth Fernandez-Ruiz, Paulo Rogerio Julio, Simone Appenzeller, Timothy B. Niewold
Summary: This article reviews the role and potential drivers of IFN-I dysregulation in five prototypic autoimmune diseases and discusses current therapeutic strategies targeting the IFN-I system.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Immunology
Jonathan Lopez, Marine Mommert, William Mouton, Andres Pizzorno, Karen Brengel-Pesce, Mehdi Mezidi, Marine Villard, Bruno Lina, Jean-Christophe Richard, Jean-Baptiste Fassier, Valerie Cheynet, Blandine Padey, Victoria Duliere, Thomas Julien, Stephane Paul, Paul Bastard, Alexandre Belot, Antonin Bal, Jean-Laurent Casanova, Manuel Rosa-Calatrava, Florence Morfin, Thierry Walzer, Sophie Trouillet-Assant
Summary: The nasal IFN-I/III signature in mildly symptomatic COVID-19 patients correlates with serum IFN-a(2) levels, while critically ill patients with autoantibodies against IFN-I showed low nasal IFN-I/III scores despite high viral loads. Functional assays confirmed the role of autoantibodies in compromising the antiviral effects of IFN-I at the early stages of SARS-CoV-2 infection.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Shane T. Killarney, Rachel Washart, Ryan S. Soderquist, Jacob P. Hoj, Jamie Lebhar, Kevin H. Lin, Kris C. Wood
Summary: During apoptosis, the release of mitochondrial RNA into the cytosol can be prevented by casp3/7, which inhibits inflammatory signaling. Inhibition of casp3/7 promotes a cytosolic mtRNA-driven Type I interferon response, increasing the immunogenicity of chemotherapy-induced apoptosis.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Ka Lung Cheung, Anbalagan Jaganathan, Yuan Hu, Feihong Xu, Alannah Lejeune, Rajal Sharma, Cristina I. Caescu, Jamel Meslamani, Adam Vincek, Fan Zhang, Kyung Lee, Nilesh Zaware, Amina Abdul Qayum, Chunyan Ren, Mark H. Kaplan, John Cijiang He, Huabao Xiong, Ming-Ming Zhou
Summary: This study uncovers a previously unrecognized mechanism of self-directed cell type-specific regulation of the master transcription factor Stat3 through its own transcriptional target Hipk2 in Th17 cell differentiation. These findings provide insights into the regulation of Th17 cell immune functions and suggest a therapeutic strategy for developing targeted therapies for Th17-associated inflammatory disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Huan Hu, Yaxiu Feng, Ming-Liang He
Summary: Zika virus (ZIKV) infection causes neurological disorders and elicits a wide range of immune response. Type I interferons (IFNs) and its signaling cascade play a crucial role in innate immunity against ZIKV infection, but ZIKV can antagonize them. Toll-like receptors 3 (TLR3), TLR7/8 and RIG-I-like receptor 1 (RIG-1) recognize the ZIKV genome and induce the expression of Type I IFNs and interferon-stimulated genes (ISGs). ISGs exert antiviral activity at different stages of the ZIKV life cycle. The NS proteins of ZIKV directly interact with factors in the pathways to evade innate immunity, while structural proteins and antibody-binding of BDCA2 or inflammasome activation enhance ZIKV replication. In this review, recent findings about the interaction between ZIKV infection and type I IFNs pathways are summarized, and potential strategies for antiviral drug development are suggested.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Cell Biology
Qiuqin Ma, Shihui Long, Zhending Gan, Gianluca Tettamanti, Kang Li, Ling Tian
Summary: Autophagy, a widely conserved process in eukaryotes, is regulated by nutrient deprivation, energy stress, and other unfavorable conditions through multiple pathways. It is primarily governed at the RNA and protein levels in a synergistic manner.
Article
Cell Biology
Jodi L. Karnell, Yanping Wu, Nanette Mittereder, Michael A. Smith, Michele Gunsior, Li Yan, Kerry A. Casey, Jill Henault, Jeffrey M. Riggs, Simone M. Nicholson, Miguel A. Sanjuan, Katherine A. Vousden, Victoria P. Werth, Jorn Drappa, Gabor G. Illei, William A. Rees, John N. Ratchford
Summary: Plasmacytoid dendritic cells (pDCs) are specialized in producing IFN and regulating immune responses, with persistent activation in autoimmune diseases. VIB7734, a monoclonal antibody, effectively depletes pDCs, reduces IFN activity, and improves clinical disease activity in animal models and patients. Biomarker analysis suggests that VIB7734 may be more effective in individuals with high baseline IFN activity, supporting further development in IFN-associated diseases.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Emilie Bourdonnay, Thomas Henry
Summary: Gasdermins (GSDM) are a family of proteins that play important roles in cell death, immune response, disease susceptibility, and treatment response. The expression of GSDM genes is influenced by various factors and has been associated with diseases such as asthma, inflammatory bowel disease, and cancer.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Immunology
Chengbo Zhu, Jingrui Li, Chaonan Tian, Mengmeng Qin, Zhenni Wang, Bingjun Shi, Guanggang Qu, Chunyan Wu, Yuchen Nan
Summary: The study identified potential ISGylation protein targets by capturing ISG15-conjugated proteins from IFN-stimulated porcine cell lysates using a novel monoclonal antibody and analyzing them with proteomics-based tools. The results indicated a moderate bias towards specific upstream amino acid residues in confirmed ISGylation sites and suggested that ISG15-conjugated substrate proteins are associated with host metabolism, especially nucleotide metabolic pathways, potentially participating in cellular antiviral defenses. Additionally, several ISGs were identified as putative ISGylation substrates, indicating a regulatory loop involving ISGylation of ISGs themselves.
Review
Pharmacology & Pharmacy
Sebastian Bruera, Thandiwe Chavula, Riya Madan, Sandeep. K. K. Agarwal
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with diverse clinical manifestations. Recent studies have highlighted the important role of the type I interferon (IFN) pathway in SLE pathogenesis. Therapeutic strategies targeting type I IFN and related pathways are being developed for the treatment of SLE. This review discusses the role of type I IFN in SLE pathogenesis and its potential as a biomarker and therapeutic target for SLE patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Akaash Mundra, Aram Yegiazaryan, Haig Karsian, Dijla Alsaigh, Victor Bonavida, Mitchell Frame, Nicole May, Areg Gargaloyan, Arbi Abnousian, Vishwanath Venketaraman
Summary: Tuberculosis (TB) is a leading cause of mortality, and its rates have increased during the emergence of COVID-19. This review explores the detrimental effects of high levels of type I interferons (IFNs) on the host fighting TB infection. The findings suggest that increased type I IFNs can affect immune cell functions, promote inflammation, and inhibit production of protective substances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Pascal Lapierre, Fernando Alvarez
Summary: There are two types of autoimmune hepatitis (AIH): AIH-1, characterized by anti-nuclear and/or anti-smooth muscle autoantibodies, and AIH-2, associated with anti-Liver kidney microsome and/or anti-Liver Cytosol antibodies. The autoantigens targeted by AIH-2 autoantibodies are specific to liver cells. AIH-2 has distinct clinical features, such as younger age at diagnosis, fulminant hepatitis in very young patients, higher prevalence in children, and association with extrahepatic T cell-mediated autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agronomy
Hongli Li, Gangshuai Liu, Daqi Fu
Summary: Tomato is a model plant for studying fruit ripening and quality formation. The ripening of tomato fruit is regulated by transcription factors, such as RIN, NOR, and CNR. Understanding the transcriptional network and regulatory patterns of ripening-related target genes in tomato has important biological significance.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yanna Shi, Bai-Jun Li, Guanqing Su, Mengxue Zhang, Donald Grierson, Kun-Song Chen
Summary: Fleshy fruit texture is an important quality characteristic of ripe fruit, and softening is an irreversible process mainly caused by changes in cell wall, starch degradation, and flavonoid levels. Lignification of certain fruits negatively affects eating quality, and excessive softening can lead to physical damage and infection. Transcription factors play a crucial role in regulating fruit texture by controlling genes related to cell wall and starch metabolism. This review focuses on the transcriptional regulatory mechanisms governing fruit textural change and discusses potential targets for breeding and future research directions.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)