Article
Biochemistry & Molecular Biology
Maha K. Rahim, Trine Line H. Okholm, Kyle B. Jones, Elizabeth E. McCarthy, Candace C. Liu, Jacqueline L. Yee, Stanley J. Tamaki, Diana M. Marquez, Iliana Tenvooren, Katherine Wai, Alexander Cheung, Brittany R. Davidson, Vrinda Johri, Bushra Samad, William E. O'Gorman, Matthew F. Krummel, Annemieke van Zante, Alexis J. Combes, Michael Angelo, Lawrence Fong, Alain P. Algazi, Patrick Ha, Matthew H. Spitzer
Summary: CD8+ T cell responses in lymph nodes play a critical role in anti-tumor immunity in human head and neck squamous cell carcinomas. These responses are associated with specific T cells in circulation and provide important insights for immune-based therapies in cancer.
Article
Immunology
Lucia Biscari, Cintia Daniela Kaufman, Cecilia Farre, Victoria Huhn, Maria Florencia Pacini, Camila Bulfoni Balbi, Karina Andrea Gomez, Ana Rosa Perez, Andres Alloatti
Summary: This article presents a vaccination strategy based on dendritic cells (DCs) activated with LPS to enhance CD8(+) T cell responses against specific pathogens. The study found that this immunization scheme provides protection and reduces parasite burden in female mice, but not in male mice.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Daichi Kobayashi, Yuki Sugiura, Eiji Umemoto, Akira Takeda, Hisashi Ueta, Haruko Hayasaka, Shinsuke Matsuzaki, Tomoya Katakai, Makoto Suematsu, Itaru Hamachi, Gennady G. Yegutkin, Marko Salmi, Sirpa Jalkanen, Masayuki Miyasaka
Summary: The study found that eATP in uninflamed lymph node paracortex is produced by naive T cells responding to chemokines, inhibiting CCR7-mediated lymphocyte migration through the P2X7 receptor subtype. This demonstrates the fine-tuning role of eATP in regulating homeostatic cell migration within lymph nodes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Kwei-Yan Liu, Yajing Gao, Wenfeng Xiao, Jinrong Fu, Saihua Huang, Xiao Han, Shih-Hsien Hsu, Xiaojun Xiao, Shau-Ku Huang, Yufeng Zhou
Summary: The exposure to PM2.5 and PAHs affects Tfh cells and immune function, enhancing allergic reactions and pulmonary inflammation. The PM2.5 (IP)-AhR-c-Maf axis plays an important role in allergen sensitization and lung inflammation.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Immunology
Jose Mateus, Paola Nocua, Paola Lasso, Manuel Carlos Lopez, M. Carmen Thomas, Adriana Egui, Claudia Cuervo, John Mario Gonzalez, Concepcion J. Puerta, Adriana Cuellar
Summary: The study investigates the relationship between parasite control and immune T cell responses in Chagas disease by using distinct infection approaches in an animal model. Different infection outcomes were observed in single or mixed T. cruzi infection with different genotypes, leading to differential immune CD8(+) T cell responses. This suggests that the quality of the CD8(+) T cell response may dictate differences in infection outcomes during chronic T. cruzi infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Jasmin D. Haslbauer, Carl Zinner, Anna K. Stalder, Jan Schneeberger, Thomas Menter, Stefano Bassetti, Kirsten D. Mertz, Philip Went, Matthias S. Matter, Alexandar Tzankov
Summary: A study on pulmonary draining lymph nodes of COVID-19 cases revealed dysregulated immune responses, including accumulation of extrafollicular plasmablasts, T-cell dysregulation, macrophage activation, and microvascular dysfunction.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jose L. Saenz-Garcia, Beatriz S. Borges, Normanda Souza-Melo, Luiz V. Machado, Juliana S. Miranda, Lisandro Alfonso Pacheco-Lugo, Nilmar S. Moretti, Richard Wheleer, Lia C. Soares Medeiros, Wanderson D. DaRocha
Summary: The flagellum of Trypanosomatids contributes to multiple functions, and this study explores the role of Trypanin in T. cruzi. The deletion of Trypanin affects the growth and motility of T. cruzi epimastigotes, as well as their infection capacity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Xuejun Zhang, Chuan Yu, Jin-Qing Liu, Xue-Feng Bai
Summary: CD24 is a cell surface glycoprotein that functions as a co-stimulatory molecule. However, its role on antigen presenting cells during T cell responses is not well understood. This study shows that CD24 deficiency in hosts leads to inefficient expansion and accelerated cell death of adoptively transferred CD4(+) T cells in lymph nodes, resulting in inadequate T cell priming. Transgenic expression of CD24 on dendritic cells restores T cell accumulation and survival in draining lymph nodes, suggesting a novel role of CD24 in optimal T cell priming.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Hengcheng Zhang, Cecilia B. Cavazzoni, Manuel A. Podesta, Elsa D. Bechu, Garyfallia Ralli, Pragya Chandrakar, Jeong-Mi Lee, Ismail Sayin, Stefan G. Tullius, Reza Abdi, Anita S. Chong, Bruce R. Blazar, Peter T. Sage
Summary: This study found that a specific subset of effector Tfh cells was activated during allogeneic kidney transplantation, and these cells played a crucial role in transplant rejection by regulating the clonal dynamics of donor-specific germinal center B cells.
Article
Immunology
Sergio M. Borghi, Victor Fattori, Thacyana T. Carvalho, Vera L. H. Tatakihara, Tiago H. Zaninelli, Felipe A. Pinho-Ribeiro, Camila R. Ferraz, Larissa Staurengo-Ferrari, Rubia Casagrande, Wander R. Pavanelli, Fernando Q. Cunha, Thiago M. Cunha, Phileno Pinge-Filho, Waldiceu A. Verri
Summary: The study reveals the contribution of spinal cord and ganglia cellular and molecular events to pain in T. cruzi infection, providing a better understanding of CD pathology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Daniel Pardo-Rodriguez, Paola Lasso, Jose Mateus, John Mendez, Concepcion J. Puerta, Adriana Cuellar, Jorge Robles, Claudia Cuervo
Summary: This study evaluated the trypanocidal effect and cytokine production induction of extracts obtained from Clethra fimbriata, a plant traditionally used as a febrifuge, on Trypanosoma cruzi. The hexane extract showed the highest activity against the parasite and low cytotoxicity, and it also induced the production of cytokines IFN-γ and TNF.
Article
Chemistry, Multidisciplinary
Shuai Liu, Xu Wang, Xueliang Yu, Qiang Cheng, Lindsay T. Johnson, Sumanta Chatterjee, Di Zhang, Sang M. Lee, Yehui Sun, Ting-Chih Lin, John L. Liu, Daniel J. Siegwart
Summary: The study introduces a rational design and combinatorial synthesis of zwitterionic phospholipidated polymers (ZPPs) for efficient mRNA delivery to spleen and lymph nodes, with potential for substantial immunotherapeutic applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Immunology
Fatima Ferragut, Karen M. Cruz, Juan P. Gallardo, Marisa Fernandez, Yolanda Hernandez Vasquez, Karina A. Gomez
Summary: This study focuses on T-cell assays that define the parasite-specificity based on upregulation of TCR stimulation-induced surface markers. The results demonstrate the efficacy of activation-induced markers (AIM) assays in detecting T. cruzi-specific CD4(+) and CD8(+) T cells in chronic Chagas disease patients, using different combinations of surface markers. Additionally, this approach is also successful in identifying the phenotype of activated T lymphocytes based on the expression of CD45RA and CCR7.
Article
Immunology
Ana Carolina Leao, Laila Almeida Viana, Fernanda Fortes de Araujo, Rodrigo de Lourdes Almeida, Leandro Martins Freitas, Anderson Coqueiro-dos-Santos, Denise da Silveira-Lemos, Mariana Santos Cardoso, Joao Luis Reis-Cunha, Andrea Teixeira-Carvalho, Daniella C. Bartholomeu
Summary: Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits high genetic and phenotypic diversity. The MASP family, located on the surface of T. cruzi, is involved in host-parasite interaction. Recombinant MASP proteins were used to investigate their immunogenicity in mice infected with different strains of T. cruzi. Flow cytometry analysis showed changes in MASP recognition profile during infection.
MICROBES AND INFECTION
(2022)
Review
Biology
Oscar Hernan Rodriguez-Bejarano, Catalina Avendano, Manuel Alfonso Patarroyo
Summary: Chagas disease, caused by Trypanosoma cruzi parasite, is mainly transmitted by insect bites. The parasite's lifecycle includes an intracellular phase and infective forms, involving various signaling cascades and intracellular associations for recognition and internalization in host cells.
Article
Cell Biology
Daiane Cristina F. Golbert, Eliane Santana-Van-Vliet, Marcelo Ribeiro-Alves, Marbella Maria B. da Fonseca, Ailin Lepletier, Daniella Areas Mendes-da-Cruz, Guilherme Loss, Vinicius Cotta-de-Almeida, Ana Tereza R. Vasconcelos, Wilson Savino
CELL ADHESION & MIGRATION
(2018)
Article
Infectious Diseases
Danielle Silva-dos-Santos, Juliana Barreto-de-Albuquerque, Barbara Guerra, Otacilio C. Moreira, Luiz Ricardo Berbert, Mariana Tavares Ramos, Barbara Angelica S. Mascarenhas, Constanca Britto, Alexandre Morrot, Dea M. Serra Villa-Verde, Luciana Ribeiro Garzoni, Wilson Savino, Vinicius Cotta-de-Almeida, Juliana de Meis
PLOS NEGLECTED TROPICAL DISEASES
(2017)
Editorial Material
Immunology
Vinicius Cotta-de-Almeida, Loic Dupre, Wilson Savino
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Arildo Nerys-Junior, Luciene P. Braga-Dias, Paula Pezzuto, Vinicius Cotta-de-Almeida, Amilcar Tanuri
GENETICS AND MOLECULAR BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Julia P. Lemos, Salete Smaniotto, Carolina V. Messias, Otacilio C. Moreira, Vinicius Cotta-de-Almeida, Mireille Dardenne, Wilson Savino, Daniella A. Mendes-da-Cruz
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Review
Immunology
Arnon Dias Jurberg, Vinicius Cotta-de-Almeida, Jairo Ramos Temerozo, Wilson Savino, Dumith Chequer Bou-Habib, Ingo Riederer
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Endocrinology & Metabolism
Ednea Oliveira-de-Abreu, Danielle Silva-dos-Santos, Ailin Lepletier, Tiago D. P. Ramos, Rafaella Ferreira-Reis, Larissa Vasconcelos-Fontes, Mariana T. Ramos, Rafael C. Torres, Vinicius Cotta-de-Almeida, Vinicius de Frias Carvalho, Dea M. S. Villa-Verde
FRONTIERS IN ENDOCRINOLOGY
(2018)
Review
Immunology
Juliana Barreto de Albuquerque, Danielle Silva dos Santos, Jens V. Stein, Juliana de Meis
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Education, Scientific Disciplines
Thais Faggioni, Natiele Carla da Silva Ferreira, Renato Matos Lopes, Antonio Augusto Fidalgo-Neto, Vinicius Cotta-de-Almeida, Luiz Anastacio Alves
ADVANCES IN PHYSIOLOGY EDUCATION
(2019)
Article
Immunology
Monica Losada-Barragan, Adriana Umana-Perez, Jonathan Duraes, Sergio Cuervo-Escobar, Andres Rodriguez-Vega, Flavia L. Ribeiro-Gomes, Luiz R. Berbert, Fernanda Morgado, Renato Porrozzi, Daniella Areas Mendes-da-Cruz, Priscila Aquino, Paulo C. Carvalho, Wilson Savino, Myriam Sanchez-Gomez, Gabriel Padron, Patricia Cuervo
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Article
Immunology
Sujana Sivapatham, Xenia Ficht, Juliana Barreto de Albuquerque, Nicolas Page, Doron Merkler, Jens V. Stein
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Ana Alcaraz-Serna, Eugenio Bustos-Moran, Irene Fernandez-Delgado, Diego Calzada-Fraile, Daniel Torralba, Ester Marina-Zarate, Erika Lorenzo-Vivas, Enrique Vazquez, Juliana Barreto de Alburquerque, Nora Ruef, Manuel Jose Gomez, Fatima Sanchez-Cabo, Ana Dopazo, Jens Stein, Almudena Ramiro, Francisco Sanchez-Madrid
Summary: Researchers have discovered that dendritic cells switch their transcriptomic signature, epigenomic changes, and enhanced migratory capacity after forming productive immune synapses with T cells.
Review
Cell Biology
Juliana Barreto de Albuquerque, Christoph Mueller, Bilgi Gungor
Summary: Tissue-resident memory T (T-RM) cells play a crucial role in rapid immune protection and chronic inflammatory disorders, with potential for immunopathological reactions. Researchers focus on the role of T-RM cells in the intestine and discuss potential therapeutic strategies to interfere with diseases mediated by these cells.
Article
Immunology
Luiz Ricardo Berbert, Florencia Belen Gonzalez, Silvina Raquel Villar, Carlos Vigliano, Susana Lioi, Juan Beloscar, Oscar Adelmo Bottasso, Suse Dayse Silva-Barbosa, Wilson Savino, Ana Rosa Perez
Summary: Chronic Chagas disease patients with chronic chagasic myocarditis show increased expression of fibronectin, CXCL12, and TNF-alpha in heart tissue, as well as enhanced membrane expression of HLA-DR and VLA-4 on T lymphocytes. This suggests the presence of a cardiac inflammatory infiltrate vector in these patients that promotes the recruitment and accumulation of activated T cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Juliana Barreto de Albuquerque, Lukas M. Altenburger, Jun Abe, Diego von Werdt, Stefanie Wissmann, Jose Martinez Magdaleno, David Francisco, Geert van Geest, Xenia Ficht, Matteo Iannacone, Remy Bruggmann, Christoph Mueller, Jens Stein
Summary: The study identifies mandibular lymph nodes as sentinel lymphoid organs in intercepting ingested Listeria monocytogenes. Oral uptake of Lm leads to the activation and release of antigen-specific CD8(+) T cells, contributing to rapid clearance of the pathogen. Interestingly, CD8(+) T-EFF generated in the upper GI tract lack gut-seeking phenotype compared to those generated in the lower GI tract.
SCIENCE IMMUNOLOGY
(2022)