Article
Biochemistry & Molecular Biology
Sven Kuspiel, Dominik Wiemuth, Stefan Gruender
Summary: Research shows that the neuropeptide nocistatin does not directly activate ASIC1a channels, but rather indirectly activates them by acidifying the bath solution. This indicates the complexity of the regulatory mechanism of acid-sensing ion channels.
Article
Multidisciplinary Sciences
Ben Cristofori-Armstrong, Elena Budusan, Lachlan D. Rash
Summary: The study compared the potency and mechanism of action of mambalgins on rat and human ASIC1 variants, revealing that mambalgin-3 weakly inhibits human ASIC1b under severe acidosis, but potentiates currents under mild/moderate acidosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Shao-hua Luan, Yu-qing Yang, Man-ping Ye, Hui Liu, Qiu-fan Rao, Jin-ling Kong, Fan-rong Wu
Summary: Activation of hepatic stellate cells (HSCs) is a key cause of liver fibrosis. Acid-sensing ion channel 1a (ASIC1a) has been found to play an important role in the development of inflammatory diseases and may also contribute to liver fibrosis. Our study reveals that ASIC1a affects HSC activation through the exosomal miR-301a-3p/BTG1 axis. Inhibiting ASIC1a could potentially be a promising treatment strategy for liver fibrosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Neurosciences
Miguel Salinas, Pascal Kessler, Dominique Douguet, Daad Sarraf, Nicolo Tonali, Robert Thai, Denis Servent, Eric Lingueglia
Summary: This study elucidated the inhibition mechanism of the snake venom toxin Mamb-1 on the acid-sensing ion channel ASIC1a through structure-activity relationship, molecular dynamics simulation, and experimental research. It provides important insights for further improvement and optimization of ASIC blockers.
Review
Neurosciences
Victoria S. Foster, Lachlan D. Rash, Glenn F. King, Michelle M. Rank
Summary: This review discusses the expression of ASICs in peripheral and CNS-resident immune cells, and how their activation during pathological tissue acidosis can affect immune cell function, modulating inflammatory pathology in the CNS. It also highlights the importance of understanding the contribution of ASICs to immune cell function in neuropathology for potential therapeutic benefits.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biology
Yi Liu, Jichun Ma, Renee L. DesJarlais, Rebecca Hagan, Jason Rech, David Lin, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael Maher
Summary: Liu et al's study reveals that small molecules can allosterically inhibit ASIC1 channel activation and desensitization by binding at the acidic pocket and stabilizing the closed state of the channel.
COMMUNICATIONS BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Stefan Kopf, Varun Kumar, Zoltan Kender, Zhe Han, Thomas Fleming, Stephan Herzig, Peter P. Nawroth
Summary: Patients with diabetes have a higher risk of developing idiopathic pulmonary fibrosis, and recent studies have shown that diabetes can cause pulmonary fibrosis by triggering DNA damage, senescence, and inflammation. Replacing the term idiopathic pulmonary fibrosis with diabetes-induced pulmonary fibrosis may provide a more accurate diagnosis. Further research is needed to determine how patients with diabetes respond to established therapies compared to non-diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Wei Wang, Mengyun Xu, Jiayin Yue, Qilun Zhang, Xiaomin Nie, Yan Jin, Zhi Zhang
Summary: ASIC1a in the PVN may serve as a potential new target for the therapeutic intervention of metabolic disorders.
Article
Cell Biology
Kangcheng Zhao, Ran An, Qian Xiang, Gaocai Li, Kun Wang, Yu Song, Zhiwei Liao, Shuai Li, Wenbin Hua, Xiaobo Feng, Xinghuo Wu, Yukun Zhang, Abhirup Das, Cao Yang
Summary: Extracellular lactate regulates intercellular reactive oxygen species (ROS) levels through ASIC1 and ASIC3, activating the NF-kappa B signaling pathway to promote NLRP3 inflammasome activation and IL-1 beta release, ultimately contributing to NP degeneration.
CELL PROLIFERATION
(2021)
Article
Chemistry, Physical
Prabha Soundharraja, Durgalakshmi Dhinasekarana, Ajay Rakkesh Rajendran
Summary: This study reports a new material for detecting NADH, which exhibits good sensitivity and has been validated in human blood plasma samples. The sustainable composite material could be a suitable material for diagnosing diabetes at an early stage in clinical applications.
SURFACES AND INTERFACES
(2023)
Article
Multidisciplinary Sciences
Xuzhong Yang, Chao Lin, Xudong Chen, Shouqin Li, Xueming Li, Bailong Xiao
Summary: This study reveals the structures and mechanisms of PIEZO1 channels in lipid membranes through observations of reconstituted PIEZO1 channels in liposome vesicles. It is found that PIEZO1 channels undergo substantial deformation in lipid membranes and the gating of the ion-conducting pathway is achieved through membrane tension-induced structural rearrangement. These findings provide important insights into the mechanosensitivity and curvature-based gating mechanism of PIEZO1 channels.
Review
Medicine, General & Internal
Fernanda Iafusco, Giovanna Maione, Francesco Maria Rosanio, Enza Mozzillo, Adriana Franzese, Nadia Tinto
Summary: Cystic fibrosis, caused by mutations in the CFTR gene, is the most common autosomal recessive disease in the Caucasian population. Cystic fibrosis-related diabetes (CFRD) is a common nonpulmonary complication, with a prevalence that increases with age and is influenced by various factors. Genetic factors, including CFTR genotype, play a role in the development of CFRD.
Article
Biology
Eva Kaulich, Trae Carroll, Brian D. Ackley, Yi-Quan Tang, Iris Hardege, Keith Nehrke, William R. Schafer, Denise S. Walker
Summary: Biological clocks are essential for an organism's health, regulating the periodicity of behavior and metabolism. This study identifies two acid-sensing ion channels with different proton sensing properties and explores their role in the defecation motor program (DMP) of the nematode Caenorhabditis elegans. The findings demonstrate the importance of these channels in pH regulation, calcium signaling, and the generation of an ultradian oscillator.
Article
Neurosciences
Qing-Rui Qin, Zhong-Qing Xu, Ting-Ting Liu, Xue-Mei Li, Chun-Yu Qiu, Wang-Ping Hu
Summary: The activation of CCK-8/CCK2R enhances ASIC-mediated electrophysiological activity in DRG neurons and nociception in rats, suggesting that CCK-8/CCK2R could be an important therapeutic target for ASIC-mediated pain.
Review
Immunology
Yayun Xu, Feihu Chen
Summary: ASIC1a is implicated in the pathogenesis of rheumatoid arthritis by promoting inflammation and joint damage. Blocking ASIC1a may offer a potential therapeutic approach to improve RA symptoms by regulating the biological processes of articular cartilage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Toxicology
Yinghong Wang, Yancai Sun, Longquan Zuo, Yanan Wang, Yan Huang
TOXICOLOGY LETTERS
(2019)
Article
Cell Biology
Longquan Zuo, Yueqin Zhu, Lili Hu, Yanyi Liu, Yinghong Wang, Yamin Hu, Huan Wang, Xuesheng Pan, Kuayue Li, Na Du, Yan Huang
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Yueqin Zhu, Xuesheng Pan, Na Du, Kuayue Li, Yamin Hu, Lili Wang, Jin Zhang, Yanyi Liu, Longquan Zuo, Xiaoming Meng, Chengmu Hu, Xian Wu, Juan Jin, Wenyong Wu, Xiangtao Chen, Fanrong Wu, Yan Huang
Article
Pharmacology & Pharmacy
Xuesheng Pan, Yueqin Zhu, Xian Wu, Lan Liu, Ruixue Ying, Lili Wang, Na Du, Jin Zhang, Juan Jin, Xiaoming Meng, Fang Dai, Yan Huang
Summary: The study demonstrates that insulin deficiency is a key factor in causing diabetes-related brain complications, involving the interaction between ASIC1a and ERS. Silencing CHOP and ASIC1a can alleviate the pro-apoptotic effect of insulin deficiency on nerve cells. Insulin deficiency leads to increased ERS, promoting neuronal apoptosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yinghong Wang, Jin Zhang, Peng Jiang, Kai Li, Yancai Sun, Yan Huang
Summary: Hepatocellular carcinoma (HCC) is highly metastatic and its development is closely related to the acidic microenvironment, where Acid-sensing ion Channel la (ASIC1a) plays a significant role in promoting tumor cell migration and invasion. Additionally, autophagy may be a mechanism for tumor cells to adapt to the acidic microenvironment. Inhibition of ASIC1a can reduce autophagy flux and potentially affect HCC cell migration and invasion.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Na Du, Kun Wu, Jin Zhang, Lili Wang, Xuesheng Pan, Yueqin Zhu, Xian Wu, Jinghao Liu, Yun Chen, Ying Ye, Yuanyuan Wang, Wenyong Wu, Wenming Cheng, Yan Huang
Summary: In this study, it was found that the tetracyclic triterpenoid inonotsuoxide B (IB) extract can regulate macrophage polarization by increasing the level of M2 macrophages and decreasing inflammatory response. The mechanism may involve the SIRT1/ERS signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Li Wu, Fu-Rong Yang, Mu-Lan Xing, Sheng-Feng Lu, Hong-Lin Chen, Qiao-Wei Yang, Yu-Ting Zhang, Yin Lu, Yan Huang
Summary: This study investigates the effects of Dahuang Zhechong pill (DHZCP) on hepatocellular carcinoma (HCC) by regulating Treg/Th1 balance. The findings suggest that DHZCP inhibits the differentiation of Tregs, reverses the balance of Treg/Th1, and improves tumor immunity. Furthermore, the study reveals the multi-target mechanism and material basis of DHZCP.
Article
Pharmacology & Pharmacy
Yinghong Wang, Xiaojie Hu, Yancai Sun, Yan Huang
Summary: This review focuses on the role of ASIC1a in several inflammatory immune diseases, providing new perspectives for clinical treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Yinghong Wang, Hong Zhou, Yancai Sun, Yan Huang
Summary: This review summarizes the role and mechanism of acid-sensing ion channel 1 (ASIC1) in tumors and finds that ASIC1 is involved in the occurrence and development of various related tumors, providing new perspectives for tumor therapeutic targets.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Yangyang Li, Anqi Zhang, Kuayue Li, Dahai Zhao, Feng Li, Songyan Liao, Yunting Zhang, Yan Huang
Summary: In this study, the researchers investigated the promoting effect of ASIC1a on LPS-induced ALI and its mechanisms. They found that ASIC1a induces apoptotic response in ALI through mitochondrial apoptosis. Pretreatment with the ASIC1a specific blocker PcTx-1 inhibited both the pathological changes of ALI and lung dysfunction. PcTx-1 also reduced the expression of apoptosis-related proteins and reversed the changes in mitochondrial membrane potential and calcium influx.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Wenfang Zhu, Yiwen Zhang, Yinghong Wang
Summary: Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating disease caused by various factors, with no effective treatment currently available. The main pathological feature is inflammation storm, with immune cells and their secreted cytokines playing a critical role in the pathogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Xiaojie Hu, Qinglin Ge, Yunting Zhang, Bowen Li, Erli Cheng, Yinghong Wang, Yan Huang
Summary: Hepatic fibrosis is a common pathological process characterized by inflammation and excessive accumulation of extracellular matrix in the liver. Recent studies have shown the significant role of exosomes in the pathogenesis of hepatic fibrosis. This review systematically analyzes and summarizes the potential role of exosomes in promoting, inhibiting, and treating hepatic fibrosis, providing a clinical reference for their diagnostic and therapeutic use.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)