Combination therapy in pulmonary arterial hypertension: do we have the right strategy?

Systematic review of trials using vasodilators in pulmonary arterial hypertension: Why a new approach is needed

(2010) Alejandro Macchia et al.   AMERICAN HEART JOURNAL

Adrenergic Receptor Blockade Reverses Right Heart Remodeling and Dysfunction in Pulmonary Hypertensive Rats

(2010) Harm J. Bogaard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Imatinib in Pulmonary Arterial Hypertension Patients with Inadequate Response to Established Therapy

(2010) Hossein A. Ghofrani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Long-term Effects of Epoprostenol on the Pulmonary Vasculature in Idiopathic Pulmonary Arterial Hypertension

(2010) Stuart Rich et al.   CHEST

Basic Science of Pulmonary Arterial Hypertension for Clinicians

(2010) Stephen L. Archer et al.   CIRCULATION

Predicting Survival in Pulmonary Arterial Hypertension

(2010) Raymond L. Benza et al.   CIRCULATION

Survival in Patients With Idiopathic, Familial, and Anorexigen-Associated Pulmonary Arterial Hypertension in the Modern Management Era

(2010) Marc Humbert et al.   CIRCULATION

Assessment of endpoints in pulmonary arterial hypertension associated with connective tissue disease

(2010) J Gerry Coghlan et al.   CURRENT OPINION IN PULMONARY MEDICINE

Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study

(2010) H. A. Ghofrani et al.   EUROPEAN RESPIRATORY JOURNAL

Treating pulmonary arterial hypertension: is it worth it?

(2010) J. S. R. Gibbs   HEART

Pharmacologic and Pharmacokinetic Rationale for Combination Therapy in Pulmonary Arterial Hypertension

(2010) Roman Gokhman et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Cardiomyocyte PDGFR-β signaling is an essential component of the mouse cardiac response to load-induced stress

(2010) Vishnu Chintalgattu et al.   JOURNAL OF CLINICAL INVESTIGATION

Addition of Inhaled Treprostinil to Oral Therapy for Pulmonary Arterial Hypertension

(2010) Vallerie V. McLaughlin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Right ventricular pacing improves right heart function in experimental pulmonary arterial hypertension: a study in the isolated heart

(2009) M. Louis Handoko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Right Ventricle Under Pressure

(2009) Harm J. Bogaard et al.   CHEST

ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension

(2009) et al.   CIRCULATION

Tadalafil Therapy for Pulmonary Arterial Hypertension

(2009) Nazzareno Galiè et al.   CIRCULATION

A Dosing/Cross-Development Study of the Multikinase Inhibitor Sorafenib in Patients With Pulmonary Arterial Hypertension

(2009) M Gomberg-Maitland et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A meta-analysis of randomized controlled trials in pulmonary arterial hypertension

(2009) N. Galie et al.   EUROPEAN HEART JOURNAL

Survival in pulmonary arterial hypertension: a reappraisal of the NIH risk stratification equation

(2009) T. Thenappan et al.   EUROPEAN RESPIRATORY JOURNAL

First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension

(2009) F. Grimminger et al.   EUROPEAN RESPIRATORY JOURNAL

Guidelines for the diagnosis and treatment of pulmonary hypertension

(2009) et al.   EUROPEAN RESPIRATORY JOURNAL

Acute Hemodynamic Effects of Single-Dose Sildenafil When Added to Established Bosentan Therapy in Patients With Pulmonary Arterial Hypertension: Results of the COMPASS-1 Study

(2009) Ekkehard Gruenig et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Addition of Prostanoids in Pulmonary Hypertension Deteriorating on Oral Therapy

(2009) Wouter Jacobs et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Future Perspectives for the Treatment of Pulmonary Arterial Hypertension

(2009) Hossein A. Ghofrani et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Phosphodiesterase Type 5 Inhibitors for Pulmonary Arterial Hypertension

(2009) Stephen L. Archer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treprostinil-Based Therapy in the Treatment of Moderate-to-Severe Pulmonary Arterial Hypertension*: Long-term Efficacy and Combination With Bosentan

(2008) Raymond L. Benza et al.   CHEST

Uncertainties in the Diagnosis and Treatment of Pulmonary Arterial Hypertension

(2008) Hossein A. Ghofrani et al.   CIRCULATION

Combined Tyrosine and Serine/Threonine Kinase Inhibition by Sorafenib Prevents Progression of Experimental Pulmonary Hypertension and Myocardial Remodeling

(2008) Martina Klein et al.   CIRCULATION

Ambrisentan for the Treatment of Pulmonary Arterial Hypertension

(2008) Nazzareno Galiè et al.   CIRCULATION

Additional Effects of Bosentan in Patients With Idiopathic Pulmonary Arterial Hypertension Already Treated With High-Dose Epoprostenol

(2008) Satoshi Akagi et al.   CIRCULATION JOURNAL

Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: does selectivity matter?

(2008) Christian F. Opitz et al.   EUROPEAN HEART JOURNAL

Prostacyclin therapies for the treatment of pulmonary arterial hypertension

(2008) M. Gomberg-Maitland et al.   EUROPEAN RESPIRATORY JOURNAL

Pulmonary Arterial Hypertension

(2008) Kelly M. Chin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial

(2008) N Galiè et al.   LANCET

Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension

(2008) Robert Voswinckel et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS