Article
Oncology
Dan Li, Yanan Cao, Juan Wang, Haiyan Yang, Weina Liu, Jinfeng Cui, Wenxin Wu
Summary: High expression of HMGA2 in colorectal cancer tissues compared with adjacent normal tissues suggests its potential involvement in the carcinogenesis of sporadic colorectal tubular adenoma, possibly through synergistic interaction with the Wnt/beta-catenin signaling pathway. Experimental results also indicate coordinated regulation between HMGA2 and Wnt/beta-catenin signaling pathway in carcinogenesis of sporadic colorectal tubular adenoma.
Article
Mathematical & Computational Biology
Peter Mendik, Mark Kerestely, Sebestyen Kamp, David Deritei, Nina Kunsi, Zsolt Vassy, Peter Csermely, Daniel V. Veres
Summary: Regulation of translocating proteins is crucial in defining cellular behavior. This study used a compartmentalized Boolean network model to simulate the functions of translocating proteins in EMT and discovered organelle-specific functions of these proteins. The results also predicted the role of key factors in the regulation of EMT.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Sarah Koushyar, Valerie S. Meniel, Toby J. Phesse, Helen B. Pearson
Summary: Aberrant activation of the Wnt pathway is closely related to tumor formation, progression, and therapeutic resistance in prostate cancer. Targeting the Wnt pathway for prostate cancer treatment has shown potential efficacy. However, the functional consequences of activating the Wnt pathway during different stages of prostate cancer progression are still unclear. Preclinical research on targeting Wnt signaling in the treatment of prostate cancer is crucial for identifying effective treatment strategies and improving patient care.
Article
Multidisciplinary Sciences
Pratyusha Bala, Jonathan P. Rennhack, Daulet Aitymbayev, Clare Morris, Sydney M. Moyer, Gina N. Duronio, Paul Doan, Zhixin Li, Xiaoyan Liang, Jason L. Hornick, Matthew B. Yurgelun, William C. Hahn, Nilay S. Sethi
Summary: Cell state plasticity is regulated in adult epithelia to prevent cancer, but its expansion in neoplasia is poorly understood. Mouse models and patient samples revealed that impaired differentiation precedes cancer development, with aberrant transcriptional state marked by Ly6a and reactivation of fetal genes. Genetic inactivation of Sox9 prevents adenoma formation and restores multilineage differentiation. These findings indicate that unabated regenerative activity and developmental reprogramming contribute to the aberrant cell state plasticity preceding cancer development.
Article
Oncology
Teresa Catalano, Emira D'Amico, Carmelo Moscatello, Maria Carmela Di Marcantonio, Alessio Ferrone, Giuseppina Bologna, Federico Selvaggi, Paola Lanuti, Roberto Cotellese, Maria Cristina Curia, Rossano Lattanzio, Gitana Maria Aceto
Summary: The dysregulation of Wnt pathways in colorectal cancer is influenced by oxidative stress, leading to modulation of APC and beta-Catenin proteins. This study sheds light on the potential impact of oxidative distress on Wnt signaling functions in CRC and suggests avenues for developing personalized therapeutic approaches.
Article
Genetics & Heredity
Winston R. Becker, Stephanie A. Nevins, Derek C. Chen, Roxanne Chiu, Aaron M. Horning, Tuhin K. Guha, Rozelle Laquindanum, Meredith Mills, Hassan Chaib, Uri Ladabaum, Teri Longacre, Jeanne Shen, Edward D. Esplin, Anshul Kundaje, James M. Ford, Christina Curtis, Michael P. Snyder, William J. Greenleaf
Summary: Single-cell ATAC-seq and RNA-seq profiling were used to study the transformation process from healthy colon to precancerous adenomas to colorectal cancer. Most of the polyp and CRC cells exhibited a stem-like phenotype. The study identified a continuum of epigenetic and transcriptional changes that occur in stem-like cells as they progress from homeostasis to CRC. The results also revealed the presence of T cell exhaustion and specific fibroblast subtypes in advanced polyps and cancerous states. Additionally, DNA methylation changes were found to be negatively correlated with accessibility changes, providing potential regulatory markers for polyp staging.
Article
Biochemistry & Molecular Biology
Pathirennehelage Chandrasekera, Mark Perfetto, Congyu Lu, Minghui Zhuo, Harinath Bahudhanapati, Jiejing Li, Wei-Chih Chen, Pallavi Kulkarni, Laura Christian, Jun Liu, Yvette Y. Yien, Chundong Yu, Shuo Wei
Summary: This study demonstrates that ADAM9 in mammals can cleave ephrin-B1 and ephrin-B2, promoting neural crest induction. The study also found that ADAM9 expression is elevated in colorectal cancer (CRC) tissues and knocking down ADAM9 inhibits the migration and invasion of CRC cells, mediated by reducing Akt kinase activity. Additionally, the study reveals differential effects of ADAM9 knockdown on Wnt signaling and mTOR signaling in different CRC cell lines.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Lingling Li, Yulu Hu, Yunshan Xu, Sanyi Tang
Summary: Cumulative mutations in driver genes are the essential cause of cancer, including colorectal cancer. This study explores the mutation orders of the driver genes KRAS, APC, and TP53 in colorectal cancer patients and identifies the pathways that best fit the incidence rate of colorectal cancer at different ages. The findings provide guidelines for the treatment strategy of colorectal cancer.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Oncology
Jiri Svec, Monika Stastna, Lucie Janeckova, Dusan Hrckulak, Martina Vojtechova, Jakub Onhajzer, Vitezslav Kriz, Katerina Galuskova, Eva Sloncova, Jan Kubovciak, Lucie Pfeiferova, Jan Hrudka, Radoslav Matej, Petr Waldauf, Lukas Havluj, Michal Kolar, Vladimir Korinek
Summary: TROP2 is overexpressed in colorectal cancer and is associated with negative prognostic factors such as lymph node metastases and poor tumor differentiation. Its expression is regulated by the Wnt/β-catenin signaling pathway and YAP.
Article
Gastroenterology & Hepatology
Nianshuang Li, Xinbo Xu, Yuan Zhan, Xiao Fei, Yaobin Ouyang, Pan Zheng, Yanan Zhou, Cong He, Chuan Xie, Yi Hu, Junbo Hong, Nonghua Lu, Zhongming Ge, Yin Zhu
Summary: This study investigates the crosstalk between the Yes-associated protein 1 (YAP) and beta-catenin pathways in H. pylori-associated gastric tumorigenesis. The findings suggest that YAP and beta-catenin synergistically promote H. pylori-induced gastric carcinogenesis through their physical interaction, and identify CDX2, LGR5, and RUVBL1 as downstream genes shared by both pathways.
Article
Oncology
Kathleen A. O'Leary, Debra E. Rugowski, Michael P. Shea, Ruth Sullivan, Amy R. Moser, Linda A. Schuler
Summary: Prolactin (PRL) collaborates with Apc(Min/+) to increase tumor incidence and modulate cancer stem cell activity through Notch-driven signals, shedding light on mechanisms whereby PRL elevates risk of breast cancer.
Article
Oncology
Anna S. Nikonova, Alexander Y. Deneka, Flaviane N. Silva, Shabnam Pirestani, Rossella Tricarico, Anna A. Kiseleva, Yan Zhou, Emmanuelle Nicolas, Douglas B. Flieder, Sergei I. Grivennikov, Erica A. Golemis
Summary: Colorectal cancer (CRC) is a common cancer with high incidence and mortality rates. Autosomal dominant polycystic kidney disease (ADPKD) caused by PKD1 gene mutations may have a protective effect against CRC. Loss of Pkd1 reduces CRC incidence and tumor growth in mouse models, although it enhances pro-oncogenic signaling pathways. Furthermore, Pkd1 loss improves colon barrier function and reduces inflammation, potentially influencing the development and treatment of CRC.
Article
Biochemistry & Molecular Biology
Wei Li, Xi Yang, Xiaowei Liu, Hao Deng, Xiaohui He, Wenbin Zhang, Yisong Shen, Xiang Li, Qiwang Peng, Debing Liu
Summary: This study reveals that SETDB1 is highly expressed in colorectal cancer and is associated with poor prognosis. SETDB1 promotes invasion and metastasis of colorectal cancer through direct methylation of beta-catenin in the Wnt/beta-catenin pathway. The activation of the Wnt/beta-catenin pathway can decrease the metastatic ability mediated by SETDB1.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2023)
Review
Oncology
Kuang He, Wen-Juan Gan
Summary: The Wnt/beta-catenin signaling pathway is closely associated with the carcinogenesis and progression of colorectal cancer (CRC), playing a crucial role in cancer-related processes. Hyperactivation of the pathway is observed in almost all CRC cases and contributes to cancer stem cell propagation, angiogenesis, epithelial-mesenchymal transition (EMT), chemoresistance, and metastasis. This review will discuss the involvement of the Wnt/beta-catenin signaling pathway in CRC and potential therapeutic approaches.
CANCER MANAGEMENT AND RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Qiyun Xiao, Johannes Werner, Nachiyappan Venkatachalam, Kim E. Boonekamp, Matthias P. Ebert, Tianzuo Zhan
Summary: Targeting cancer hallmarks is crucial for improving anti-cancer treatment, but cross-talk between signaling pathways often leads to resistance. This article provides an overview of the molecular interactions between the p53 and Wnt pathways in cancer, including complex feedback loops and reciprocal transactivation, as well as the mutational landscape of genes associated with these pathways.
Article
Physiology
U. Rajamani, D. Joseph, S. Roux, M. F. Essop
Article
Plant Sciences
S. Williams, S. Roux, T. Koekemoer, M. van de Venter, G. Dealtry
JOURNAL OF ETHNOPHARMACOLOGY
(2013)
Article
Nutrition & Dietetics
Cheryl Stevenson, Renee Blaauw, Ernst Fredericks, Janicke Visser, Saartjie Roux
Article
Chemistry, Medicinal
Janine MacKenzie, Trevor C. Koekemoer, Saartjie Roux, Maryna van deVenter, Gill B. Dealtry
PHYTOTHERAPY RESEARCH
(2012)
Article
Plant Sciences
O. Ibraheem, C. E. J. Botha, G. Bradley, G. Dealtry, S. Roux
Article
Pharmacology & Pharmacy
Olusola B. Adewale, Hajierah Davids, Lynn Cairncross, Saartjie Roux
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2019)
Article
Toxicology
M. C. Pereira, O. B. Adewale, S. Roux, L. Cairncross, H. Davids
Summary: The study investigated the neurotoxic impact of peptide-targeted gold nanoparticles in a rat model and found that PEG-coated AuNP-peptide conjugates showed potential safety for colorectal cancer diagnosis. On the other hand, exposure to citrate-capped AuNPs could induce delayed neuro-inflammation, warranting further investigation.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Sendibitiyosi Gandidzanwa, Natasha Beukes, Sinelizwi Joseph, Arno Janse Van Vuuren, Philani Mashazi, Jonathan Britton, Gareth Kilian, Saartjie Roux, Tebello Nyokong, Michael E. Lee, Carminita L. Frost, Zenixole R. Tshentu
Summary: Folate receptor-targeted therapy shows promise in breast cancer treatment. Folate-conjugated palladium-based nanoparticles with non-toxic concentrations were utilized to specifically target breast cancer cells with overexpressed folate receptors. The nanoparticles were found to selectively accumulate in cancer cells relative to normal cells, as demonstrated by qualitative and quantitative analysis using transmission electron microscopy and inductively coupled plasma-optical emission spectroscopy. These findings support the potential use of folate-conjugated palladium nanoparticles in targeting breast cancer cells for radiopharmaceutical applications.
Article
Nutrition & Dietetics
Cheryl Stevenson, Renee Blaauw, Ernst Fredericks, Janicke Visser, Saartjie Roux
Summary: This study investigated the effects of probiotics on gut microbiota and symptoms of irritable bowel syndrome (IBS), finding that the probiotic had no significant impact on symptoms and microbiota profiles. Certain nutrients were strongly correlated with specific bacterial profiles, suggesting that nutrients may play a significant role in influencing gastrointestinal microbiota composition.
SOUTH AFRICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Infectious Diseases
Trusha Nana, Chanelle Moore, Tom Boyles, Adrian J. Brink, Joy Cleghorn, Lesley M. Devenish, Briette du Toit, Ernst S. Fredericks, Molebogeng R. Lekalakala-Mokaba, Caroline Maluleka, Muhammad N. Rajabally, Gary Reubenson, Liliwe Shuping, Karin Swart, Khine Swe Swe Han, Jeannette Wadula, Justyna Wojno, Warren Lowman
SOUTHERN AFRICAN JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Plant Sciences
Omodele Ibraheem, Gill Dealtry, Saartjie Roux, Graeme Bradley
Article
Nutrition & Dietetics
C. Stevenson, R. Blaauw, E. Fredericks, S. Roux
SOUTH AFRICAN JOURNAL OF CLINICAL NUTRITION
(2014)