A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens

DNA vaccines against cancer come of age

(2010) Freda K Stevenson et al.   CURRENT OPINION IN IMMUNOLOGY

Prolonged Antigen Storage Endows Merocytic Dendritic Cells with Enhanced Capacity To Prime Anti-Tumor Responses in Tumor-Bearing Mice

(2010) R. A. Reboulet et al.   JOURNAL OF IMMUNOLOGY

Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell–licensed DCs

(2010) Verena Semmling et al.   NATURE IMMUNOLOGY

T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model

(2009) A. Di Stasi et al.   BLOOD

Cyclophosphamide Augments Antitumor Immunity: Studies in an Autochthonous Prostate Cancer Model

(2009) S. Wada et al.   CANCER RESEARCH

Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome

(2009) M. Gobert et al.   CANCER RESEARCH

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

(2009) Karl S. Peggs et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Analysis and Characterization of Antitumor T-cell Response After Administration of Dendritic Cells Loaded With Allogeneic Tumor Lysate to Metastatic Melanoma Patients

(2009) Nadege Bercovici et al.   JOURNAL OF IMMUNOTHERAPY

Mechanisms maintaining peripheral tolerance

(2009) Daniel L Mueller   NATURE IMMUNOLOGY

Toward the Discovery of Vaccine Adjuvants: Coupling In Silico Screening and In Vitro Analysis of Antagonist Binding to Human and Mouse CCR4 Receptors

(2009) Matthew N. Davies et al.   PLoS One

Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines

(2008) M. A. Morse et al.   BLOOD

The Wilms' Tumor Antigen Is a Novel Target for Human CD4+ Regulatory T Cells: Implications for Immunotherapy

(2008) C. Lehe et al.   CANCER RESEARCH

Genetic Regulation of the Response to Her-2 DNA Vaccination in Human Her-2 Transgenic Mice

(2008) O. Radkevich-Brown et al.   CANCER RESEARCH

Comparative methodologies of regulatory T cell depletion in a murine melanoma model

(2008) Norimasa Matsushita et al.   JOURNAL OF IMMUNOLOGICAL METHODS

In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination

(2008) J. Bayry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA