3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models

Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules

(2012) T. K. Kelly et al.   GENOME RESEARCH

Gene Reactivation by 5-Aza-2′-Deoxycytidine–Induced Demethylation Requires SRCAP–Mediated H2A.Z Insertion to Establish Nucleosome Depleted Regions

(2012) Xiaojing Yang et al.   PLoS Genetics

Cancer Chemoprevention by Targeting the Epigenome

(2011) Joseph Huang et al.   CURRENT DRUG TARGETS

Chromatin higher-order structures and gene regulation

(2011) Guohong Li et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells

(2011) María J. Ruiz-Magaña et al.   INTERNATIONAL JOURNAL OF CANCER

DNA Methyltransferase Inhibitor, Zebularine, Delays Tumor Growth and Induces Apoptosis in a Genetically Engineered Mouse Model of Breast Cancer

(2011) M. Chen et al.   MOLECULAR CANCER THERAPEUTICS

Azacytidine and Decitabine Induce Gene-Specific and Non-Random DNA Demethylation in Human Cancer Cell Lines

(2011) Sabine Hagemann et al.   PLoS One

GSTP1 DNA Methylation and Expression Status Is Indicative of 5-aza-2′-Deoxycytidine Efficacy in Human Prostate Cancer Cells

(2011) Karen Chiam et al.   PLoS One

DNA methylation topology: potential of a chromatin landmark for epigenetic drug toxicology

(2011) Jian Tajbakhsh   Epigenomics

5-Aza-2′-deoxycytidine stress response and apoptosis in prostate cancer

(2011) Aditi Patra et al.   Clinical Epigenetics

Chromatin Remodeling Is Required for Gene Reactivation after Decitabine-Mediated DNA Hypomethylation

(2010) J. Si et al.   CANCER RESEARCH

Genome-wide DNA methylation profiling of chronic lymphocytic leukemia allows identification of epigenetically repressed molecular pathways with clinical impact

(2010) Wei-Gang Tong et al.   Epigenetics

5-azacytidine treatment reorganizes genomic histone modification patterns

(2010) Vitalina M. Komashko et al.   Epigenetics

Measuring topology of low-intensity DNA methylation sites for high-throughput assessment of epigenetic drug-induced effects in cancer cells

(2010) Arkadiusz Gertych et al.   EXPERIMENTAL CELL RESEARCH

The Effect of Cell Cycle Synchronization on Tumor Sensitivity to Reovirus Oncolysis

(2010) Lucy Heinemann et al.   MOLECULAR THERAPY

Principles and challenges of genome-wide DNA methylation analysis

(2010) Peter W. Laird   NATURE REVIEWS GENETICS

Mechanistic Insights on the Inhibition of C5 DNA Methyltransferases by Zebularine

(2010) Christine Champion et al.   PLoS One

An Integrated Genomic and Epigenomic Approach Predicts Therapeutic Response to Zebularine in Human Liver Cancer

(2010) J. B. Andersen et al.   Science Translational Medicine

Higher-order Genome Organization in Human Disease

(2010) T. Misteli   Cold Spring Harbor Perspectives in Biology

Epigenetic mechanisms and genome stability

(2010) Emily L. Putiri et al.   Clinical Epigenetics

Capturing the dynamic epigenome

(2010) Roger B Deal et al.   GENOME BIOLOGY

DNA (Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site

(2009) Dana M. van Bemmel et al.   BIOCHEMICAL PHARMACOLOGY

Epigenetic DNA-(cytosine-5-carbon) modifications: 5-aza-2′-deoxycytidine and DNA-demethylation

(2009) S. K. Patra et al.   BIOCHEMISTRY-MOSCOW

Hunting for the 5th base: Techniques for analyzing DNA methylation

(2009) Ole Ammerpohl et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells

(2009) Madhavi Billam et al.   BREAST CANCER RESEARCH AND TREATMENT

Automated quantification of DNA demethylation effects in cells via 3D mapping of nuclear signatures and population homogeneity assessment

(2009) Arkadiusz Gertych et al.   CYTOMETRY PART A

Cytomics for discovering drugs

(2009) Attila Tárnok   CYTOMETRY PART A

Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology

(2009) Antonei B. Csoka et al.   MEDICAL HYPOTHESES

An oestrogen-receptor-α-bound human chromatin interactome

(2009) Melissa J. Fullwood et al.   NATURE

Chromatin profiling by directly sequencing small quantities of immunoprecipitated DNA

(2009) Alon Goren et al.   NATURE METHODS

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

DNA hypomethylation in cancer cells

(2009) Melanie Ehrlich   Epigenomics

Heterochromatic Genome Stability Requires Regulators of Histone H3 K9 Methylation

(2009) Jamy C. Peng et al.   PLoS Genetics

Epigenetics, DNA Methylation, and Chromatin Modifying Drugs

(2008) Moshe Szyf   Annual Review of Pharmacology and Toxicology

Drug-induced senescence bystander proliferation in prostate cancer cells in vitro and in vivo

(2008) J A Ewald et al.   BRITISH JOURNAL OF CANCER

Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development

(2008) Samir Kumar Patra et al.   CANCER AND METASTASIS REVIEWS

Epigenetic regulation of heterochromatic DNA stability

(2008) Jamy C Peng et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Hypomethylation and apoptosis in 5-azacytidine–treated myeloid cells

(2008) Rasheed Khan et al.   EXPERIMENTAL HEMATOLOGY

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine

(2008) Carlo Stresemann et al.   INTERNATIONAL JOURNAL OF CANCER

Azacytidine causes complex DNA methylation responses in myeloid leukemia

(2008) C. Stresemann et al.   MOLECULAR CANCER THERAPEUTICS

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE

Epigenetic regulation of telomeres in human cancer

(2008) E Vera et al.   ONCOGENE