Novel strategies for catalytic asymmetric synthesis of C1-chiral 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydrotetrahydroisoquinolines

Efficient merging of copper and photoredox catalysis for the asymmetric cross-dehydrogenative-coupling of alkynes and tetrahydroisoquinolines

(2015) Inna Perepichka et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and Biological Evaluation of NovelN-Alkyl Tetra- and Decahydroisoquinolines: Novel Antifungals that Target Ergosterol Biosynthesis

(2014) Jürgen Krauss et al.   ARCHIV DER PHARMAZIE

Ruthenium(II)/Chiral Brønsted Acid Co-Catalyzed Enantioselective Four-Component Reaction/Cascade Aza-Michael Addition for Efficient Construction of 1,3,4-Tetrasubstituted Tetrahydroisoquinolines

(2014) Jun Jiang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Amine-Catalyzed Enantioselective 1,3-Dipolar Cycloadditions of Aldehydes to C,N-Cyclic Azomethine Imines

(2014) Wenjun Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Synthesis of Tetrahydroquinolines through a [3+2] Cycloaddition Controlled by Dienamine Catalysis

(2014) Wenjun Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Optimization of Potency and Pharmacokinetic Properties of Tetrahydroisoquinoline Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists

(2014) Daniel B. Horne et al.   JOURNAL OF MEDICINAL CHEMISTRY

Direct sp3 C–H acroleination of N-aryl-tetrahydroisoquinolines by merging photoredox catalysis with nucleophilic catalysis

(2014) Zhu-Jia Feng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Organocatalyzed Asymmetric Oxidative Coupling of α-Csp3-H of Tertiary Amines to α,β-Unsaturated γ-Butyrolactam: Synthesis of MBH-Type Products

(2014) Yunxia Ma et al.   ORGANIC LETTERS

A highly enantioselective acyl-Mannich reaction of isoquinolines with aldehydes promoted by proline derivatives: an approach to 13-alkyl-tetrahydroprotoberberine alkaloids

(2014) L. Mengozzi et al.   Chemical Science

1-Aryl-1,2,3,4-tetrahydroisoquinolines as potential antimalarials: synthesis, in vitro antiplasmodial activity and in silico pharmacokinetics evaluation

(2014) Joelle Ngo Hanna et al.   RSC Advances

Highly efficient and general enantioselective synthesis of naturally occurring isoquinoline alkaloids

(2014) Weilong Lin et al.   Organic Chemistry Frontiers

Complex Bioactive Alkaloid-Type Polycycles through Efficient Catalytic Asymmetric Multicomponent Aza-Diels-Alder Reaction of Indoles with Oxetane as Directing Group

(2013) Zhilong Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Double Manipulation of Tetrahydroisoquinolines with Terminal Alkynes and Aldehydes under Copper(I) Catalysis

(2013) Weilong Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Hydrogenation of Isoquinolines

(2013) Dongbing Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and Synthesis of a Tetrahydroisoquinoline-Based Hydroxamate Derivative (ZYJ-34v), An Oral Active Histone Deacetylase Inhibitor with Potent Antitumor Activity

(2013) Yingjie Zhang et al.   Chemical Biology & Drug Design

Design, Synthesis, and Biological Evaluation of Erythrina Alkaloid Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists

(2013) François Crestey et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enantioselective 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines to Unsaturated Nitriles Catalyzed by NiII–Pigiphos

(2013) Sandra Milosevic et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Cross-Dehydrogenative Coupling Enabled by the Design and Application of Chiral Triazole-Containing Phosphoric Acids

(2013) Andrew J. Neel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective synthesis of almorexant via iridium-catalysed intramolecular allylic amidation

(2013) Martín Fañanás-Mastral et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

CuI-Catalyzed C1-Alkynylation of Tetrahydroisoquinolines (THIQs) by A3 Reaction with Tunable Iminium Ions

(2013) Qin-Heng Zheng et al.   ORGANIC LETTERS

Catalytic asymmetric α-C(sp3)–H functionalization of amines

(2013) Yan Qin et al.   TETRAHEDRON LETTERS

Controlling stereoselectivity by enzymatic and chemical means to access enantiomerically pure (1S,3R)-1-benzyl-2,3-dimethyl-1,2,3,4-tetrahydroisoquinoline derivatives

(2013) Alejandro A. Orden et al.   TETRAHEDRON-ASYMMETRY

Chiral organic contact ion pairs in metal-free catalytic enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to ketones

(2013) Gen Zhang et al.   Chemical Science

Photoredox activation and anion binding catalysis in the dual catalytic enantioselective synthesis of β-amino esters

(2013) Giulia Bergonzini et al.   Chemical Science

Discovery of Tetrahydroisoquinoline-Based CXCR4 Antagonists

(2013) Valarie M. Truax et al.   ACS Medicinal Chemistry Letters

The First Catalytic, Enantioselective Aza-Henry Reaction of an Unactivated Cyclic Imine

(2012) Nilupa R. Amarasinghe et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Oxidative Cross-Dehydrogenative Coupling of Tertiary Amines to Aldehydes

(2012) Junmin Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective [3+3] Cycloaddition of Aromatic Azomethine Imines with Cyclopropanes Directed by π-π Stacking Interactions

(2012) You-Yun Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective tert-Aminocyclization by Asymmetric Binary Acid Catalysis (ABC): Stereospecific 1,5-Hydrogen Transfer

(2012) Liujuan Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Synthesis of Hexahydropyrrolo-isoquinolines by an Organocatalytic Three-Component Reaction

(2012) Alberto Fraile et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biosynthetic Progress of the Tetrahydroisoquinoline Antitumor Antibiotics

(2012) Mancheng Tang et al.   CHINESE JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Metal/Organo-Catalyzed Aerobic Oxidative sp3C–H Olefination of Tertiary Amines Using Molecular Oxygen as the Sole Oxidant

(2012) Gen Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Asymmetric α-Acylation of Tertiary Amines Mediated by a Dual Catalysis Mode: N-Heterocyclic Carbene and Photoredox Catalysis

(2012) Daniel A. DiRocco et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phase-Transfer-Catalyzed Asymmetric Synthesis of 1,1-Disubstituted Tetrahydroisoquinolines

(2011) Seiji Shirakawa et al.   ADVANCED SYNTHESIS & CATALYSIS

Iridium-Catalyzed Asymmetric Intramolecular Allylic Amidation: Enantioselective Synthesis of Chiral Tetrahydroisoquinolines and Saturated Nitrogen Heterocycles

(2011) Johannes F. Teichert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Alkynylation of C1-Substituted C,N-Cyclic Azomethine Imines by CuI/Chiral Brønsted Acid Co-Catalyst

(2011) Takuya Hashimoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Activation of a C sp 3H Bond Adjacent to a Nitrogen Atom: A Versatile Approach to Optically Active α-Alkyl α-Amino Acids and C1-Alkylated Tetrahydroisoquinoline Derivatives

(2011) Gen Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Inverse-Electron-Demand 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines: An Umpolung Strategy

(2011) Takuya Hashimoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Pictet-Spengler Reaction in Nature and in Organic Chemistry

(2011) Joachim Stöckigt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tetrahydroisoquinoline-Based N-Oxides as Chiral Organocatalysts for the Asymmetric Allylation of Aldehydes

(2011) Tricia Naicker et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Dehydrogenative coupling reactions catalysed by Rose Bengal using visible light irradiation

(2011) Yuanhang Pan et al.   GREEN CHEMISTRY

Discovery of a Tetrahydroisoquinoline-Based Hydroxamic Acid Derivative (ZYJ-34c) as Histone Deacetylase Inhibitor with Potent Oral Antitumor Activities

(2011) Yingjie Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Dual-Catalysis Approach to the Asymmetric Steglich Rearrangement and Catalytic Enantioselective Addition ofO-Acylated Azlactones to Isoquinolines

(2011) Chandra Kanta De et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Asymmetric Synthesis of trans-1,3-Disubstituted Tetrahydroisoquinolines via a Reductive Amination/Aza-Michael Sequence

(2010) Dieter Enders et al.   CHEMISTRY-A EUROPEAN JOURNAL

Privileged scaffolds for library design and drug discovery

(2010) Matthew E Welsch et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Catalytic Enantioselective 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines with α,β-Unsaturated Aldehydes

(2010) Takuya Hashimoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of 1-Aryltetrahydroisoquinolines

(2010) Sa Wang et al.   ORGANIC LETTERS

Synthesis of tetrahydroisoquinoline-diamine ligands and their application in asymmetric transfer hydrogenation

(2010) Byron K. Peters et al.   TETRAHEDRON-ASYMMETRY

Synthesis of tetrahydroisoquinoline (TIQ)–oxazoline ligands and their application in enantioselective Henry reactions

(2010) Rahul B. Kawthekar et al.   TETRAHEDRON-ASYMMETRY

Novel tetrahydroisoquinoline based organocatalysts for asymmetric Diels–Alder reactions: insight into the catalytic mode using ROESY NMR and DFT studies

(2010) Tricia Naicker et al.   TETRAHEDRON-ASYMMETRY

Synthesis and Screening of C1-Substituted Tetrahydroisoquinoline Derivatives for Asymmetric Transfer Hydrogenation Reactions

(2009) Sai Kumar Chakka et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Catalytic Enantioselective Intramolecular Redox Reactions: Ring-Fused Tetrahydroquinolines

(2009) Sandip Murarka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Approach to Benzofused Nitrogen-Containing Heterocycles: Enantioselective Total Synthesis of (+)-Angustureine

(2008) Santos Fustero et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper-Catalyzed Oxidative sp3C−H Bond Arylation with Aryl Boronic Acids

(2008) Olivier Baslé et al.   ORGANIC LETTERS