The Pictet-Spengler Reaction in Nature and in Organic Chemistry

Diverse Asymmetric Quinolizidine Synthesis: A Stereodivergent One-Pot Approach

(2010) Wei Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalyzed enantioselective one-pot three-component access to indoloquinolizidines by a Michael addition–Pictet–Spengler sequence

(2010) Xiaoyu Wu et al.   CHEMICAL COMMUNICATIONS

Improved Expression of His6-Tagged Strictosidine Synthase cDNA for Chemo-Enzymatic Alkaloid Diversification

(2010) Liuqing Yang et al.   CHEMISTRY & BIODIVERSITY

A Facile Chemoenzymatic Approach: One-Step Syntheses of Monoterpenoid Indole Alkaloids

(2010) Hong-Bin Zou et al.   Chemistry-An Asian Journal

The Asymmetric Pictet – Spengler Reaction

(2010) Michael Lorenz et al.   CURRENT ORGANIC SYNTHESIS

Three NewO-Methyltransferases Are Sufficient for AllO-Methylation Reactions of Ipecac Alkaloid Biosynthesis in Root Culture ofPsychotria ipecacuanha

(2010) Taiji Nomura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enantiospecific Total Synthesis of the Important Biogenetic Intermediates along the Ajmaline Pathway, (+)-Polyneuridine and (+)-Polyneuridine Aldehyde, as well as 16-Epivellosimine and Macusine A

(2010) Wenyuan Yin et al.   JOURNAL OF ORGANIC CHEMISTRY

Mechanistic Studies on theCistoTransEpimerization of Trisubstituted 1,2,3,4-Tetrahydro-β-carbolines

(2010) Michael L. Van Linn et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of Enantiopure Phalarine via a Stereospecific Pictet−Spengler Reaction: Traceless Transfer of Chirality froml-Tryptophan

(2010) John D. Trzupek et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Norcoclaurine Synthase: Mechanism of an Enantioselective Pictet-Spengler Catalyzing Enzyme

(2010) Alessandra Bonamore et al.   MOLECULES

Trends for diverse production strategies of plant medicinal alkaloids

(2010) Liuqing Yang et al.   NATURAL PRODUCT REPORTS

Construction and expression of a dual vector for chemo-enzymatic synthesis of plant indole alkaloids in Escherichia coli

(2010) Joachim Stöckigt et al.   NATURAL PRODUCT RESEARCH

Integrating carbon–halogen bond formation into medicinal plant metabolism

(2010) Weerawat Runguphan et al.   NATURE

Multistep Microwave-Assisted Divergent Synthesis of Indolo-Fused Pyrazino-/Diazepinoquinoxalinones on PEG Support

(2010) Jin-Ji Lai et al.   ORGANIC LETTERS

Direct Enantioselective Brønsted Acid CatalyzedN-Acyliminium Cyclization Cascades of Tryptamines and Ketoacids

(2010) Chloe A. Holloway et al.   ORGANIC LETTERS

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Biocatalytic asymmetric formation of tetrahydro-β-carbolines

(2010) Peter Bernhardt et al.   TETRAHEDRON LETTERS

A Critical Evaluation of Influence of Ethanol and Diet on Salsolinol Enantiomers in Humans and Rats

(2009) Jeongrim Lee et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Highly Enantioselective Pictet-Spengler Reactions with α-Ketoamide-Derived Ketimines: Access to an Unusual Class of Quaternary α-Amino Amides

(2009) Farhan R. Bou-Hamdan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aza-Tryptamine Substrates in Monoterpene Indole Alkaloid Biosynthesis

(2009) Hyang-Yeol Lee et al.   CHEMISTRY & BIOLOGY

Biology-Oriented Combined Solid- and Solution-Phase Synthesis of a Macroline-Like Compound Collection

(2009) Wolfram Wilk et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mechanistic advances in plant natural product enzymes

(2009) Aimee R Usera et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Phylogenetic analysis and functional characterisation of strictosidine synthase-like genes inArabidopsis thaliana

(2009) Natalie A. J. Kibble et al.   FUNCTIONAL PLANT BIOLOGY

Study of the Cis to Trans Isomerization of 1-Phenyl-2,3-disubstituted Tetrahydro-β-carbolines at C(1). Evidence for the Carbocation-Mediated Mechanism

(2009) Hephzibah J. Kumpaty et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Brønsted Acid-CatalyzedN-Acyliminium Cyclization Cascades

(2009) Michael E. Muratore et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alkaloid biosynthesis takes root

(2009) Katherine S Ryan et al.   Nature Chemical Biology

Metabolic reprogramming of periwinkle plant culture

(2009) Weerawat Runguphan et al.   Nature Chemical Biology

Weak Brønsted Acid−Thiourea Co-catalysis: Enantioselective, Catalytic Protio-Pictet−Spengler Reactions

(2009) Rebekka S. Klausen et al.   ORGANIC LETTERS

Targeted metabolite and transcript profiling for elucidating enzyme function: isolation of novelN-methyltransferases from three benzylisoquinoline alkaloid-producing species

(2009) David K. Liscombe et al.   PLANT JOURNAL

Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture

(2009) W. Runguphan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unexpected cis selectivity in the Pictet–Spengler reaction

(2009) Patrick D. Bailey et al.   TETRAHEDRON LETTERS

Cloning, expression, crystallization and preliminary X-ray data analysis of norcoclaurine synthase fromThalictrum flavum

(2008) Alessandra Pasquo et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Discovery of a New Class of Inhibitors ofMycobacterium tuberculosisProtein Tyrosine Phosphatase B by Biology-Oriented Synthesis

(2008) Andrea Nören-Müller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Alkaloid Synthesis: A One-Pot Organocatalytic Reaction to Quinolizidine Derivatives

(2008) Johan Franzén et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conformation, catalytic site, and enzymatic mechanism of the PR10 allergen-related enzyme norcoclaurine synthase

(2008) Hanna Berkner et al.   BIOCHEMICAL JOURNAL

N-terminal labeling of proteins by the Pictet–Spengler reaction

(2008) Tsubasa Sasaki et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Metabolic engineering for plant natural product biosynthesis in microbes

(2008) Joseph A Chemler et al.   CURRENT OPINION IN BIOTECHNOLOGY

The New β-D-Glucosidase in Terpenoid-Isoquinoline Alkaloid Biosynthesis inPsychotria ipecacuanha

(2008) Taiji Nomura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Enzymatic (S)-Norcoclaurine Biosynthesis

(2008) Andrea Ilari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solid-Phase Synthesis of Aryl-Substituted Thienoindolizines: Sequential Pictet−Spengler, Bromination and Suzuki Cross-Coupling Reactions of Thiophenes

(2008) Sebastian T. Le Quement et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Enantioselective BINOL-Phosphoric Acid Catalyzed Pictet−Spengler Reactions ofN-Benzyltryptamine

(2008) Nishant V. Sewgobind et al.   JOURNAL OF ORGANIC CHEMISTRY

General Approach to the Total Synthesis of 9-Methoxy-Substituted Indole Alkaloids: Synthesis of Mitragynine, as well as 9-Methoxygeissoschizol and 9-Methoxy-Nb-methylgeissoschizol

(2008) Jun Ma et al.   JOURNAL OF ORGANIC CHEMISTRY

Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production

(2008) Benedikt Engels et al.   METABOLIC ENGINEERING

Molecular characterization and expression analysis of a new cDNA encoding strictosidine synthase from Ophiorrhiza japonica

(2008) Yang Lu et al.   MOLECULAR BIOLOGY REPORTS

Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae

(2008) Kristy M Hawkins et al.   Nature Chemical Biology

Regio- and Enantioselective Catalytic Cyclization of Pyrroles ontoN-Acyliminium Ions

(2008) Izzat T. Raheem et al.   ORGANIC LETTERS

Phylogenetic and transcriptional analysis of a strictosidine synthase-like gene family inArabidopsis thalianareveals involvement in plant defence responses

(2008) M. M. Sohani et al.   PLANT BIOLOGY

3D-Structure and function of strictosidine synthase – the key enzyme of monoterpenoid indole alkaloid biosynthesis

(2008) Joachim Stöckigt et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Microbial production of plant benzylisoquinoline alkaloids

(2008) H. Minami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strictosidine Synthase:  Mechanism of a Pictet−Spengler Catalyzing Enzyme†

(2007) Justin J. Maresh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY