Article
Gastroenterology & Hepatology
Emir Tulumovic, Nermin Salkic, Denijal Tulumovic
Summary: A study was conducted to review the epidemiology of inflammatory bowel disease (IBD) in the Tuzla Canton of Bosnia-Herzegovina over a 10-year period. The findings showed that trends in the incidence and prevalence of IBD in the region were similar to Eastern European averages, although there were significant epidemiological differences within geographically close and demographically similar areas.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Montse Baldan-Martin, Maria Chaparro, Javier P. Gisbert
Summary: Inflammatory bowel diseases (IBDs) are chronic and inflammatory conditions affecting the gastrointestinal tract. Despite endoscopy being the gold standard test for assessing IBD, it is invasive and uncomfortable for patients. Therefore, non-invasive biomarkers for IBD diagnosis are urgently needed. This review summarizes proteomics and metabolomics studies in animals and humans, identifying urinary biomarkers for IBD diagnosis. Large-scale multi-omics studies with collaboration between clinicians, researchers, and industry are necessary for the development of sensitive and specific diagnostic biomarkers for personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Vu Q. Nguyen, Fabiano Celio, Maithili Chitnavis, Mohammad Shakhatreh, Jeffry Katz, Fabio Cominelli, Amitabh Chak, Paul Yeaton
Summary: This study examined the role of EUS in distinguishing between Crohn's disease and ulcerative colitis, finding that it can be used to diagnose active and inactive disease by measuring colon wall layer thickness and assessing transmural disease activity.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Pathology
Bence Kovari, Agnes Bathori, Mark S. Friedman, Gregory Y. Lauwers
Summary: Inflammatory bowel disease is a chronic inflammatory condition of the gastrointestinal tract, and the diagnosis relies on a synthesis of clinical, endoscopic, and microscopic features. The classic morphologic features of ulcerative colitis and Crohn disease include architectural distortion, basal plasmacytosis, and expansion of the lamina propria lymphoplasmacytic infiltrate.
ADVANCES IN ANATOMIC PATHOLOGY
(2022)
Review
Gastroenterology & Hepatology
Paulina Nunez, Noa Krugliak Cleveland, Rodrigo Quera, David T. Rubin
Summary: Endoscopic evaluation plays a crucial role in predicting disease activity and severity in inflammatory bowel diseases, with mucosal healing associated with improved clinical outcomes and incorporated into standard care. Therapeutic endoscopic options and surveillance strategies, including early detection of neoplasia, continue to advance with evolving technology and visualization techniques.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Ishan Manandhar, Ahmad Alimadadi, Sachin Aryal, Patricia B. Munroe, Bina Joe, Xi Cheng
Summary: Despite frequent misdiagnosis of inflammatory bowel diseases (IBD), this study shows promising potential of using supervised machine learning modeling to predictively diagnose different types of IBD using fecal gut microbiome data.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Tawnya M. Hansen, Zoann Nugent, Charles N. Bernstein, N. Jewel Samadder, Sanjay K. Murthy, Harminder Singh
Summary: The risk of death following CRC diagnosis is not affected by a diagnosis of IBD in recent years. There is a high proportion of post colonoscopy CRC among IBD-CRC patients, which has remained unchanged over the years and requires detailed root-cause analysis and interventions.
Review
Gastroenterology & Hepatology
Thomas M. Goodsall, Tran M. Nguyen, Claire E. Parker, Christopher Ma, Jane M. Andrews, Vipul Jairath, Robert Bryant
Summary: The study systematically identified ultrasound scoring indices for assessing inflammatory bowel disease activity, with common components including bowel wall thickness, colour Doppler imaging, and bowel wall stratification. The correlation between ultrasound indices and reference standards, as well as sensitivity, specificity, accuracy, and other properties, varied within certain ranges. However, reliability and responsiveness data were limited, and most studies were rated with unclear or high risk of bias.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Medicine, General & Internal
Katarzyna Akutko, Andrzej Stawarski
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the digestive tract with periods of remission and relapses. The etiopathogenesis is not fully understood, leading to only symptomatic treatment. There is a constant need to search for new high safety profile therapies for IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Charles N. Bernstein, Zoann Nugent, Seth Shaffer, Harminder Singh, Ruth Ann Marrie
Summary: Comorbidity is a significant predictor of disease course in IBD. The rates of certain component diseases of the Charlson Comorbidity Index were found to be increased both pre- and post-IBD diagnosis. Optimal care plans for persons with IBD should include assessment for a wide range of comorbidities involving multiple organ systems.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Biotechnology & Applied Microbiology
Guihua Chen, Jun Shen
Summary: Inflammatory bowel disease (IBD) is a global disease with high morbidity and medical costs. Early diagnosis and intervention are crucial for controlling its progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Obstetrics & Gynecology
Madeline F. Flanagan, Charlotte A. Vollgraff Heidweiller-Schreurs, Wentao Li, Wessel Ganzevoort, Marjon A. de Boer, Alicia Vazquez-Sarandeses, Ozhan M. Turan, Patrick M. Bossuyt, Ben W. J. Mol, Daniel L. Rolnik
Summary: The study aimed to investigate the prognostic value of different Doppler ultrasound measurements for adverse perinatal outcomes. The results showed that umbilical artery pulsatility index added prognostic value for adverse perinatal outcomes, while other Doppler ultrasound measurements did not further improve prognostic performance.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Respiratory System
Inge A. H. van den Berk, Maadrika M. N. P. Kanglie, Tjitske S. R. van Engelen, Josje Altenburg, Jouke T. Annema, Ludo F. M. Beenen, Bart Boerrigter, Marije K. Bomers, Paul Bresser, Elvin Eryigit, Maarten Groenink, Suzanne M. R. Hochheimer, Frits Holleman, Jos A. J. Kooter, Ramon B. van Loon, Mitran Keijzers, Ivo van der Lee, Paul Luijendijk, Lilian J. Meijboom, Saskia Middeldorp, Laura J. Schijf, Robin Soetekouw, Ralf W. Sprengers, Alexander D. Montauban van Swijndregt, Wouter de Monye, Milan L. Ridderikhof, Michiel M. Winter, Shandra Bipat, Marcel G. W. Dijkgraaf, Patrick M. M. Bossuyt, Jan M. Prins, Jaap Stoker
Summary: Replacing chest X-ray with ultra-low-dose chest CT (ULDCT) in the diagnostic work-up of patients suspected of non-traumatic pulmonary disease at the emergency department has similar effects on short-term functional health, hospital admissions, and length of stay. However, more incidental findings were found in the ULDCT group.
Article
Gastroenterology & Hepatology
Edouard Louis, Matthieu Resche-Rigon, David Laharie, Jack Satsangi, Nik Ding, Britta Siegmund, Geert D'Haens, Laurence Picon, Peter Bossuyt, Lucine Vuitton, Peter Irving, Stephanie Viennot, Christopher A. Lamb, Richard Pollok, Filip Baert, Maria Nachury, Mathurin Fumery, Cyrielle Gilletta, Sven Almer, Shomron Ben-Horin, Yoram Bouhnik, Jean-Frederic Colombel, Erik Hertervig
Summary: This study aimed to compare the relapse rate and time in remission over 2 years between patients continuing combination therapy, stopping infliximab, or stopping immunosuppressant therapy for Crohn's disease. The results showed that stopping infliximab had a higher relapse rate compared to stopping immunosuppressant therapy, suggesting that stopping immunosuppressant therapy may be a preferable strategy for treatment de-escalation.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Health Care Sciences & Services
Osama Zaidat, Shelly Ikeme, Sunil A. Sheth, Shinichi Yoshimura, Xin-guang Yang, Waleed Brinjikji, David F. Kallmes, Patrick Brouwer, John Pederson, Ranita Tarchand, Annie Steffenson, Kevin M. Kallmes, Jillienne Touchette, Tommy Andersson
Summary: A systematic review/meta-analysis compared three stent-retrievers (EmboTrap, Solitaire, and Trevo) and found that EmboTrap may be associated with significantly improved functional outcomes compared to Solitaire and Trevo. EmboTrap and Trevo may also have significantly lower rates of symptomatic intracranial hemorrhage and mortality compared to Solitaire. However, there were no significant differences in recanalization and embolization to new territory rates. Further studies comparing different stent-retriever devices are needed to confirm these findings.
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
(2023)
Meeting Abstract
Gastroenterology & Hepatology
E. Hoefkens, N. Lembrechts, P. Bossuyt, L. Pouillon
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
V. Jairath, G. Zou, Z. Wang, S. Adsul, J. F. Colombel, G. R. D'Haens, M. Freire, G. W. Moran, L. Peyrin-Biroulet, W. J. Sandborn, S. Sebastian, S. Travis, S. Vermeire, G. Radulescu, J. Sigler, S. Mcfarlane, N. Arya, M. Beaton, P. Bossuyt, D. Green, W. Harlan, M. Horynski, M. Klopocka, R. Petroniene, M. S. Silverberg, L. Wolanski, B. G. Feagan
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
E. Louis, P. Bossuyt, A. Colard, P. Caenepeel, F. Baert, A. Hantson, G. Van Gassen, J. Zhou, S. Vermeire
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
E. Louis, S. Sebastien, B. Siegmund, P. Bossuyt, S. Danese, N. De Boer, E. Loftus, B. Moum, L. Peyrin-Biroulet, S. Schreiber, J. Zhou, J. Wernicke, E. Angellotti, C. Siegel
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
N. Noor, P. Sousa, D. Bettenworth, F. Gomollon, T. Lobaton, P. Bossuyt, M. J. Casanova, N. Ding, G. Dragoni, F. Furfaro, P. van Rheenen, M. Chaparro, J. Gisbert, E. Louis, K. Papamichael
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
R. Panaccione, I. Dotan, M. Ferrante, S. Danese, P. Bossuyt, K. Kligys, E. Neimark, J. Zambrano, X. Liao, G. D'Haens
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
J. Panes, E. Louis, P. Bossuyt, N. Joshi, W. J. Lee, A. Lacerda, V. Remple, S. Xuan, E. V. Loftus
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
J. Panes, E. Louis, P. Bossuyt, N. Joshi, W. J. Lee, A. Lacerda, V. Remple, S. Xuan, E. V. Loftus
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
L. Peyrin-Biroulet, P. Bossuyt, D. Bettenworth, E. V. Loftus, S. Anjie, G. D'Haens, M. Saruta, P. Arkkila, D. H. Kim, D. Choi, W. Reinisch
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Rheumatology
Renske G. Kamperman, Hannah A. W. Walter, Joost Raaphorst, Camiel Verhamme, Johannes H. T. M. Koelman, Wouter V. Potters, Robert Hemke, Frank F. Smithuis, Eleonora Aronica, Ester M. M. van Leeuwen, Paul A. Baars, Marianne de Visser, Ivo N. van Schaik, Patrick M. M. Bossuyt, Anneke J. van der Kooi
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Health Care Sciences & Services
Matthew J. Thompson, Monica Zigman Suchsland, Victoria Hardy, Danielle C. Lavallee, Sally Lord, Emily Beth Devine, Jeffrey G. Jarvik, Steven Findlay, Thomas A. Trikalinos, Fiona M. Walter, Roger Chou, Beverly B. Green, Karen J. Wernli, Annette L. Fitzpatrick, Patrick M. Bossuyt
Summary: Imaging tests are commonly used in healthcare, but concerns about their overuse have overshadowed their benefits in clinical decision-making. This study demonstrates the importance of considering patient-centered outcomes (PCOs) when evaluating the value of imaging tests. The PROD framework categorizes PCOs into four main domains and highlights the interplay between them and the factors that can modify them.
BMJ QUALITY & SAFETY
(2023)