Tumor cell death by pattern-sensing of exogenous RNA: Tumor cell TLR3 directly induces necroptosis by poly(I:C) in vivo, independent of immune effector-mediated tumor shrinkage

Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo

(2015) Misako Matsumoto et al.   Nature Communications

PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo

(2015) R. Takemura et al.   Cancer Immunology Research

Necroptosis, in vivo detection in experimental disease models

(2014) Sandrine Jouan-Lanhouet et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Myeloid-Derived Suppressor Cells Confer Tumor-Suppressive Functions on Natural Killer Cells via Polyinosinic:Polycytidylic Acid Treatment in Mouse Tumor Models

(2013) Hiroaki Shime et al.   Journal of Innate Immunity

Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors

(2012) H. Shime et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR3/TICAM-1 signaling in tumor cell RIP3-dependent necroptosis

(2012) Tsukasa Seya et al.   OncoImmunology

Trial Watch

(2012) Lorenzo Galluzzi et al.   OncoImmunology

Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c+/CD8α+dendritic cells

(2012) Masahiro Azuma et al.   OncoImmunology

Identification of a polyI:C-inducible membrane protein that participates in dendritic cell–mediated natural killer cell activation

(2010) Takashi Ebihara et al.   JOURNAL OF EXPERIMENTAL MEDICINE