A rationally designed combined treatment with an alphavirus-based cancer vaccine, sunitinib and low-dose tumor irradiation completely blocks tumor development

Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication

(2015) Oana Draghiciu et al.   OncoImmunology

Radiation-Induced CXCL16 Release by Breast Cancer Cells Attracts Effector T Cells

(2014) S. Matsumura et al.   JOURNAL OF IMMUNOLOGY

The effect of the anti-angiogenic drug sunitinib malate on the vascular architecture of oral squamous cell carcinoma

(2014) ViníCius Faccin Bampi et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Combining low-dose or metronomic chemotherapy with anticancer vaccines

(2014) Heng Sheng Sow et al.   OncoImmunology

Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer

(2013) Cristina Iclozan et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Activation of interleukin-6/signal transducer and activator of transcription 3 by human papillomavirus early proteins 6 induces fibroblast senescence to promote cervical tumourigenesis through autocrine and paracrine pathways in tumour microenvironment

(2013) Chunxia Ren et al.   EUROPEAN JOURNAL OF CANCER

Combination of sunitinib with anti-tumor vaccination inhibits T cell priming and requires careful scheduling to achieve productive immunotherapy

(2013) Ritika Jaini et al.   INTERNATIONAL JOURNAL OF CANCER

Therapeutic immunization and local low-dose tumor irradiation, a reinforcing combination

(2013) Oana Draghiciu et al.   INTERNATIONAL JOURNAL OF CANCER

Functional Regulatory Role of STAT3 in HPV16-Mediated Cervical Carcinogenesis

(2013) Shirish Shukla et al.   PLoS One

Systemic Treatment Options for Untreated Patients With Metastatic Clear Cell Renal Cancer

(2013) Ana M. Molina et al.   SEMINARS IN ONCOLOGY

Rapid Decrease in Delivery of Chemotherapy to Tumors after Anti-VEGF Therapy: Implications for Scheduling of Anti-Angiogenic Drugs

(2012) Astrid A.M. Van der Veldt et al.   CANCER CELL

Combined vaccine+axitinib therapy yields superior antitumor efficacy in a murine melanoma model

(2012) Anamika Bose et al.   MELANOMA RESEARCH

Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer

(2012) Minu K. Srivastava et al.   PLoS One

Selected anti-tumor vaccines merit a place in multimodal tumor therapies

(2012) Eva-Maria Weiss et al.   Frontiers in Oncology

Role of regulatory T-cells in immunization strategies involving a recombinant alphavirus vector system

(2011) Mateusz Walczak et al.   ANTIVIRAL THERAPY

From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors

(2011) Oana Draghiciu et al.   Clinical & Developmental Immunology

MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy

(2011) James Finke et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A methodological framework to enhance the clinical success of cancer immunotherapy

(2011) Axel Hoos et al.   NATURE BIOTECHNOLOGY

Direct and Differential Suppression of Myeloid-Derived Suppressor Cell Subsets by Sunitinib Is Compartmentally Constrained

(2010) Jennifer S. Ko et al.   CANCER RESEARCH

Anti-inflammatory Triterpenoid Blocks Immune Suppressive Function of MDSCs and Improves Immune Response in Cancer

(2010) S. Nagaraj et al.   CLINICAL CANCER RESEARCH

Sunitinib facilitates the activation and recruitment of therapeutic anti-tumor immunity in concert with specific vaccination

(2010) Anamika Bose et al.   INTERNATIONAL JOURNAL OF CANCER

Role of T cell competition in the induction of cytotoxic T lymphocyte activity during viral vector-based immunization regimens

(2010) Annechien J.A. Lambeck et al.   VACCINE

The Novel Role of Tyrosine Kinase Inhibitor in the Reversal of Immune Suppression and Modulation of Tumor Microenvironment for Immune-Based Cancer Therapies

(2009) J. Ozao-Choy et al.   CANCER RESEARCH

Sunitinib Inhibition of Stat3 Induces Renal Cell Carcinoma Tumor Cell Apoptosis and Reduces Immunosuppressive Cells

(2009) H. Xin et al.   CANCER RESEARCH