Article
Biochemistry & Molecular Biology
He Zhang, Fei Wang, Xiangsheng Pang, Yue Zhou, Shiming Li, Wenjiong Li, Peng Zhang, Xiaoping Chen
Summary: This study investigated the role of lncRNA H19 in muscle atrophy and its underlying mechanism. The expression levels of lncRNA H19 and miR-675 were found to be reduced in muscle atrophy. Overexpression of lncRNA H19 increased Atrogin-1 mRNA expression, which was reversed by inhibiting miR-675. The downregulation of lncRNA H19/miR-675 axis may act as a protective mechanism against muscle atrophy.
MOLECULAR MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Zhijian Xu, Fengduo Zhang, Hu Xu, Fan Yang, Gezhi Zhou, Minfeng Tong, Yaqing Li, Song Yang
Summary: This study investigated the molecular mechanism of how melatonin interferes with the expression of hypoxia-inducible factor 1 alpha and toll-like receptor 4. The results showed that melatonin could down-regulate the expressions of HIF1A and TLR4 via the H19/miR-675/HIF1A/TLR4 signaling pathway, and improve neurobehavioral deficits and apoptosis caused by brain injury.
Article
Microbiology
Jun Li, Yan Zhang, Lingling Sun, Song Liu, Menghe Zhao, Bing Luo
Summary: This study found that EBV induces the overexpression of p53 protein in EBVaGC and NPC cells through the H19/miR-675-5p axis, leading to cell proliferation and apoptosis inhibition.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Jinghan Hua, Xiaolin Wang, Liying Ma, Jingxin Li, Guozhen Cao, Shaobo Zhang, Wenchu Lin
Summary: circVAPA promotes the progression of small cell lung cancer through the miR-377-3p and miR-494-3p/IGF1R/AKT axis.
Article
Cell Biology
Banyar Than Naing, Takami Takizawa, Takanobu Sakurai, Chaw Kyi-Tha-Thu, Toshihiro Takizawa
Summary: This study investigated the expression and distribution of lncRNA H19 and its derivative miRNA miR-675-3p in the mouse placenta during mid-to-late gestation using qPCR and ISH analyses. The results showed a trophoblast cell type-specific expression of lncRNA H19 and miR-675-3p during later stages of gestation. Furthermore, miR-675-3p was also found in H19-negative trophoblast cells, suggesting possible transfer between neighboring cells.
HISTOCHEMISTRY AND CELL BIOLOGY
(2023)
Article
Environmental Sciences
Heng Zhang, Xinmei Li, Mengmeng Jia, Jing Ji, Zhaoxu Wu, Xian Chen, Dianke Yu, Yuxin Zheng, Yanjie Zhao
Summary: This study constructed a ceRNA regulatory network in COE-induced lung squamous cell carcinoma using RNA sequencing and database analysis.The findings suggest that H19 functions as a ceRNA to increase COL1A1 expression by sponging miR-29a-3p, thereby promoting COE-induced cell malignant transformation.
ENVIRONMENTAL POLLUTION
(2022)
Article
Cell Biology
Hui Han, Tingyu Tian, Guoqian Huang, Dalu Li, Shimao Yang
Summary: The research indicates that melatonin regulates the osteogenic and adipogenic differentiation of bone mesenchymal stem cells through the H19/miR-541-3p/APN axis, providing a new insight for targeted therapy of osteoporosis.
Article
Cell Biology
Shuo Tan, Ye Kang, Hu Li, Hai-Qing He, Long Zheng, Shui-Qing Wu, Kai Ai, Lei Zhang, Ran Xu, Xuan-Zhi Zhang, Xiao-Kun Zhao, Xuan Zhu
Summary: Bladder cancer is an aggressive malignancy with high recurrence rates and distant metastasis, and circular RNAs (circRNAs) play important regulatory roles in cancer progression. In this study, circST6GALNAC6 was identified as downregulated in bladder cancer tissues and cells, inhibiting cell proliferation, migration, invasion, and epithelial-mesenchymal transition both in vitro and in vivo by sponging miR-200a-3p to regulate STMN1 expression. This SP1-induced circST6GALNAC6/miR-200a-3p/STMN1 axis provides potential prognostic biomarkers and therapeutic targets for bladder cancer metastasis.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Qinkai Zhang, Xunzhu Zhou, Maoping Wan, Xixi Zeng, Jiarong Luo, Yesha Xu, Liying Ji, Jian-An Zhang, Pei Fan, Jianing Zhong, Jianmin Wu
Summary: miR-150 acts as a tumor suppressor in ovarian cancer by regulating the IGF1R/IRS1 pathway. FoxP3 positively regulates miR-150 expression, forming a complex feedback loop that regulates the pathogenesis of OC.
CELL DEATH & DISEASE
(2021)
Article
Engineering, Biomedical
Ruonan Zhang, Ting Pan, Yu Xiang, Mingming Zhang, Han Xie, Zimao Liang, Bi Chen, Cong Xu, Jing Wang, Xingxing Huang, Qianru Zhu, Ziming Zhao, Quan Gao, Chengyong Wen, Wencheng Liu, Weirui Ma, Jiao Feng, Xueni Sun, Ting Duan, Elaine Lai-Han Leung, Tian Xie, Qibiao Wu, Xinbing Sui
Summary: Curcumenol has been found to induce cell death and inhibit cell proliferation in lung cancer cells. The study also reveals that the long non-coding RNA H19 (lncRNA H19) is downregulated in lung cancer cells treated with curcumenol, and its decreased expression enhances curcumenol-induced ferroptotic cell death through the miR-19b-3p/FTH1 axis.
BIOACTIVE MATERIALS
(2022)
Article
Oncology
Yulu Liu, Zhansheng Wang, Hua Huang, Kaijun Shou
Summary: The study revealed a significant decrease of miR-200a-3p in NEC and LPS-treated IEC-6 cells, with its mimetic inhibiting inflammation and necrosis, and RIPK1 identified as its downstream molecule. MiR-200a-3p plays a crucial role in protecting intestinal epithelial cells from LPS injury by inhibiting inflammation and necrosis mediated by RIPK1.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Weizhi Li, Yingchao Li, Peijie Li, Fuquan Ma, Mengying Liu, Shuzhen Kong, Hui Xue
Summary: The upregulation of HOXB5 in HCC is associated with tumor progression by activating EGFR. miR-200a-3p and miR-181-5p regulate the expression of HOXB5, affecting HCC cell proliferation and migration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Toxicology
Yemei Song, Huaixin Xing, Liqing Zhou, Nasha Zhang, Ming Yang
Summary: The study identified that a specific SNP of lncRNA H19 could impact the survival rate of HCC patients receiving TACE treatment, potentially through regulating H19 expression to affect treatment response. Additionally, knocking down lncRNA H19 can enhance the antiviability efficiency of chemotherapy drugs used in TACE on HCC cells.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shimaa Abdelsattar, Dina Sweed, Hala F. M. Kamel, Zeinab A. A. Kasemy, Abdallah M. M. Gameel, Hassan Elzohry, Omnia Ameen, Eman Ibrahim Elgizawy, Ahmed Sallam, Asmaa Mosbeh, Mahmoud S. Abdallah, Fatma O. O. Khalil, Hiba S. S. Al-Amodi, Sally M. M. El-Hefnway
Summary: Hepatocellular carcinoma (HCC) is a common cancer worldwide. The expression of lncRNA-H19 and miR-675 in tissues can be potential non-invasive biomarkers for HCC diagnosis and prognosis.
Article
Cell Biology
Changle Ji, Jiashu Hu, Xuehui Wang, Wenfang Zheng, Xiaochong Deng, Hongming Song, Yunhe Yu, Qifeng Luo, Kaiyao Hua, Xiqian Zhou, Lin Fang
Summary: The study reveals that hsa_circ_0053063 inhibits breast cancer cell proliferation by regulating the miR-330-3p/PDCD4 axis.
Article
Biochemistry & Molecular Biology
Sijing Zhou, Li Sun, Chao Cao, Peipei Wu, Min Li, Gengyun Sun, Guanghe Fei, Xing Ding, Ran Wang
JOURNAL OF CELLULAR BIOCHEMISTRY
(2018)
Review
Oncology
Yi Liu, Sijing Zhou, Yongsheng Du, Li Sun, Huihui Jiang, Binbin Zhang, Gengyun Sun, Ran Wang
CANCER MANAGEMENT AND RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Sijing Zhou, Ke Zhu, Yongsheng Du, Huihui Jiang, Min Li, Peipei Wu, Aiqun Xu, Xing Ding, Li Sun, Chao Cao, Gengyun Sun, Ran Wang
Article
Immunology
Binbin Zhang, Yi Liu, Sijing Zhou, Huihui Jiang, Ke Zhu, Ran Wang
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Medicine, Research & Experimental
Sijing Zhou, Huihui Jiang, Min Li, Peipei Wu, Li Sun, Yi Liu, Ke Zhu, Binbin Zhang, Gengyun Sun, Chao Cao, Ran Wang
MOLECULAR THERAPY-NUCLEIC ACIDS
(2019)
Article
Medicine, Research & Experimental
Ke Zhu, Sijing Zhou, Aiqun Xu, Li Sun, Min Li, Huihui Jiang, Binbin Zhang, Daxiong Zeng, Guanghe Fei, Ran Wang
MOLECULAR THERAPY-NUCLEIC ACIDS
(2020)
Review
Oncology
Ke Zhu, Aiqun Xu, Wanli Xia, Pulin Li, Binbin Zhang, Huihui Jiang, Sijing Zhou, Ran Wang
Summary: The NAT2 slow + intermediate phenotype is significantly associated with an increased risk of lung cancer, while the NAT2 rapid phenotype is associated with a reduced risk of lung cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Huihui Jiang, Aiqun Xu, Wanli Xia, Xingyuan Xia, Pulin Li, Binbin Zhang, Ke Zhu, Sijing Zhou, Ran Wang
Summary: Through comprehensive analysis, lung cancer patients treated with immunotherapy showed better overall survival (OS), progression-free survival (PFS), and objective response rate (ORR) compared to those receiving chemotherapy. Whether used alone or in combination, immunotherapy demonstrated more clinically meaningful survival benefits.
CANCER CELL INTERNATIONAL
(2021)
Review
Medicine, General & Internal
Yi Liu, Hui-Min Li, Ran Wang
Summary: The study indicates that the combination of bevacizumab with platinum-based chemotherapy in the first-line treatment of advanced NSCLC has significant benefits in terms of OS, PFS, and ORR compared to chemotherapy alone. Different doses of bevacizumab have varying effects on different chemotherapy regimens, and also increase the risk of certain adverse events.
FRONTIERS IN MEDICINE
(2021)